Anne E. Justice

ORCID: 0000-0002-8903-8712
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About
Contact & Profiles
Research Areas
  • Genetic Associations and Epidemiology
  • Nutrition, Genetics, and Disease
  • Genetic Mapping and Diversity in Plants and Animals
  • Epigenetics and DNA Methylation
  • Genetic and phenotypic traits in livestock
  • Metabolomics and Mass Spectrometry Studies
  • Birth, Development, and Health
  • Cardiovascular Health and Risk Factors
  • Adipose Tissue and Metabolism
  • Health, Environment, Cognitive Aging
  • RNA modifications and cancer
  • Air Quality and Health Impacts
  • Obesity, Physical Activity, Diet
  • Regulation of Appetite and Obesity
  • Bioinformatics and Genomic Networks
  • Adipokines, Inflammation, and Metabolic Diseases
  • Genetic factors in colorectal cancer
  • BRCA gene mutations in cancer
  • Diet and metabolism studies
  • Genomics and Rare Diseases
  • SARS-CoV-2 and COVID-19 Research
  • Cardiovascular Disease and Adiposity
  • Diet, Metabolism, and Disease
  • Genetics and Physical Performance
  • Cancer-related molecular mechanisms research

Geisinger Health System
2017-2025

Geisinger Medical Center
2018-2025

University of North Carolina at Chapel Hill
2014-2023

Institute of Population and Public Health
2023

University of Chile
2022

University of Michigan
2022

Public Health Department
2016-2021

Translational Research Informatics Center (Japan)
2019

University of North Carolina Health Care
2017-2018

Geisinger Neuroscience Institute
2018

10.1038/s41586-019-1310-4 article EN Nature 2019-06-01
Sonja I. Berndt Stefan Gustafsson Reedik Mägi Andrea Ganna Eleanor Wheeler and 95 more Mary F. Feitosa Anne E. Justice Keri L. Monda Damien C. Croteau‐Chonka Felix R. Day Tõnu Esko Tove Fall Teresa Ferreira Davide Gentilini Anne Jackson Jian’an Luan Joshua C. Randall Sailaja Vedantam Cristen J. Willer Thomas W. Winkler Andrew R. Wood Tsegaselassie Workalemahu Yi‐Juan Hu Sang Lee Liming Liang Dan-Yu Lin Josine L. Min Benjamin M. Neale Guðmar Þorleifsson Jian Yang Eva Albrecht Najaf Amin Jennifer L. Bragg‐Gresham Gemma Cadby Martin den Heijer Niina Eklund Krista Fischer Anuj Goel Jouke‐Jan Hottenga Jennifer E. Huffman Ivonne Jarick Åsa Johansson Toby Johnson Stavroula Kanoni Marcus E. Kleber Inke R. König Kati Kristiansson Zoltán Kutalik Claudia Lamina Cécile Lecœur Li Guo Massimo Mangino Wendy L. McArdle Carolina Medina‐Gómez Martina Müller‐Nurasyid Julius S. Ngwa Ilja M. Nolte Lavinia Paternoster Sonali Pechlivanis Markus Perola Marjolein J. Peters Michael Preuß Lynda M. Rose Jianxin Shi Dmitry Shungin Albert V. Smith Rona J. Strawbridge Ida Surakka Alexander Teumer Mieke D. Trip Jonathan P. Tyrer Jana V. van Vliet‐Ostaptchouk Liesbeth Vandenput Lindsay L. Waite Wei Zhao Devin Absher Folkert W. Asselbergs Mustafa Atalay Antony Attwood Anthony J. Balmforth Hanneke Basart John Beilby Lori L. Bonnycastle Paolo Brambilla Marcel Bruinenberg Harry Campbell Daniel I. Chasman Peter S. Chines Francis S. Collins John Connell William Cookson Ulf dé Fairé Femmie de Vegt Mariano Dei Maria Dimitriou Sarah Edkins Karol Estrada David M. Evans Martin Farrall Maurizio Ferrario

10.1038/ng.2606 article EN Nature Genetics 2013-04-07
Eirini Marouli Mariaelisa Graff Carolina Medina‐Gómez Ken Sin Lo Andrew R. Wood and 95 more Troels R. Kjær Rebecca S. Fine Yingchang Lu Claudia Schurmann Heather M. Highland Sina Rüeger Guðmar Þorleifsson Anne E. Justice David Lamparter Kathleen Stirrups Valérie Turcot Kristin L. Young Thomas W. Winkler Tõnu Esko Tugce Karaderi Adam E. Locke Nicholas G. D. Masca Maggie Ng Poorva Mudgal Manuel A. Rivas Sailaja Vedantam Anubha Mahajan Xiuqing Guo Gonçalo R. Abecasis Katja K.H. Aben Linda S. Adair Dewan S Alam Eva Albrecht Kristine H. Allin Matthew Allison Philippe Amouyel Emil V. R. Appel Dominique Arveiler Folkert W. Asselbergs Paul L. Auer Beverley Balkau Bernhard Banas Lia E. Bang Marianne Benn Sven Bergmann Lawrence F. Bielak Matthias Blüher Heiner Boeing Eric Boerwinkle Carsten A. Böger Lori L. Bonnycastle Jette Bork‐Jensen Michiel L. Bots Erwin P. Böttinger Donald W. Bowden Ivan Brandslund Gerome Breen Murray H. Brilliant Linda Broer Amber Burt Adam S. Butterworth David J. Carey Mark J. Caulfield John C. Chambers Daniel I. Chasman Yii‐Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y. Chu Massimiliano Cocca Francis S. Collins James P. Cook Janie Corley Jordi Corominas Galbany Amanda J. Cox Gabriel Cuéllar-Partida John Danesh Gail Davies Paul I. W. de Bakker Gert J. de Borst Simon de Denus Mark de Groot Renée de Mutsert Ian J. Deary George Dedoussis Ellen W. Demerath Anneke I. den Hollander Joe Dennis Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Alison M. Dunning Douglas F. Easton Tapani Ebeling Todd L. Edwards Patrick T. Ellinor Paul Elliott Εvangelos Εvangelou Aliki‐Eleni Farmaki Jessica D. Faul

10.1038/nature21039 article EN Nature 2017-01-31
Valérie Turcot Yingchang Lu Heather M. Highland Claudia Schurmann Anne E. Justice and 95 more Rebecca S. Fine Jonathan P. Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E. Hendricks Tugce Karaderi Adelheid Lempradl Adam E. Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L. Young Tamuno Alfred Mary F. Feitosa Nicholas G. D. Masca Alisa K. Manning Carolina Medina‐Gómez Poorva Mudgal Maggie C. Y. Ng Alex P. Reiner Sailaja Vedantam Sara M. Willems Thomas W. Winkler Gonçalo R. Abecasis Katja K.H. Aben Dewan S Alam Sameer Alharthi Matthew Allison Philippe Amouyel Folkert W. Asselbergs Paul L. Auer Beverley Balkau Lia E. Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F. Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A. Böger Jette Bork‐Jensen Michiel L. Bots Erwin P. Böttinger Donald W. Bowden Ivan Brandslund Gerome Breen Murray H. Brilliant Linda Broer Marco Brumat Amber Burt Adam S. Butterworth Peter T. Campbell Stefania Cappellani David J. Carey Eulalia Catamo Mark J. Caulfield John C. Chambers Daniel I. Chasman Yii‐Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y. Chu Massimiliano Cocca Francis S. Collins James P. Cook Janie Corley Jordi Corominas Galbany Amanda J. Cox David S. Crosslin Gabriel Cuéllar-Partida Angela D’Eustacchio John Danesh Gail Davies Paul I. W. de Bakker Mark de Groot Renée de Mutsert Ian J. Deary George Dedoussis Ellen W. Demerath Martin den Heijer Anneke I. den Hollander Hester M. den Ruijter Joe Dennis Joshua C. Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie‐Pierre Dubé Alison M. Dunning Douglas F. Easton

10.1038/s41588-017-0011-x article EN Nature Genetics 2017-12-19
Gretchen Saunders Xingyan Wang Fang Chen Seon-Kyeong Jang Mengzhen Liu and 95 more Chen Wang Shuang Gao Yu Jiang Chachrit Khunsriraksakul Jacqueline M. Otto Clifton Addison Masato Akiyama Christine M. Albert Fazil Alıev Álvaro Alonso Donna K. Arnett Allison E. Ashley‐Koch Aneel A. Ashrani Kathleen C. Barnes R. Graham Barr Traci M. Bartz Diane M. Becker Lawrence F. Bielak Emelia J. Benjamin Joshua C. Bis Gyða Björnsdóttir John Blangero Eugene R. Bleecker Jason D. Boardman Eric Boerwinkle Dorret I. Boomsma Meher P. Boorgula Donald W. Bowden Jennifer A. Brody Brian E. Cade Daniel I. Chasman Sameer Chavan Yii‐Der Ida Chen Zhengming Chen Iona Cheng Michael H. Cho Hélène Choquet John W. Cole Marilyn C. Cornelis Francesco Cucca Joanne E. Curran Mariza de Andrade Danielle M. Dick Anna R. Docherty Ravindranath Duggirala Charles B. Eaton Marissa A. Ehringer Tõnu Esko Jessica D. Faul Lilian Fernandes Silva Edoardo Fiorillo Myriam Fornage Barry I. Freedman Maiken E. Gabrielsen Melanie E. Garrett Sina A. Gharib Christian Gieger Nathan A. Gillespie David C. Glahn Scott D. Gordon C. Charles Gu Dongfeng Gu Daníel F. Guðbjartsson Xiuqing Guo Jeffrey Haessler Michael E. Hall Toomas Haller Kathleen Mullan Harris Jiang He Pamela Herd John K. Hewitt Ian B. Hickie Bertha Hidalgo John E. Hokanson Christian J. Hopfer Jouke‐Jan Hottenga Lifang Hou Hongyan Huang Yi‐Jen Hung David J. Hunter Kristian Hveem Shih‐Jen Hwang Chii‐Min Hwu William G. Iacono Marguerite R. Irvin Yon Ho Jee Eric O. Johnson Yoonjung Yoonie Joo Eric Jorgenson Anne E. Justice Yoichiro Kamatani Robert C. Kaplan Jaakko Kaprio Sharon L. R. Kardia Matthew C. Keller

Tobacco and alcohol use are heritable behaviours associated with 15% 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease injury1-4. These substances used across the globe, yet genome-wide association studies have focused on individuals European ancestries5. Here we leveraged global genetic diversity 3.4 million from four major clines ancestry (approximately 21% non-European) power discovery fine-mapping genomic loci tobacco use, inform function these via...

10.1038/s41586-022-05477-4 article EN cc-by Nature 2022-12-07
Athanasios Kousathanas Erola Pairo‐Castineira Konrad Rawlik A. Stuckey Christopher A. Odhams and 95 more Susan Walker Clark D Russell Tomas Malinauskas Yang Wu Jonathan Millar Xia Shen Katherine S. Elliott Fiona Griffiths Wilna Oosthuyzen Kirstie Morrice Seán Keating Bo Wang Daniel R. Rhodes Lucija Klarić Marie Zechner Nick Parkinson Afshan Siddiq Peter Goddard Sally Donovan David M. Maslove Alistair Nichol Malcolm G. Semple Tala Zainy F. Maleady-Crowe Linda Todd Shahla Salehi Julian C. Knight Greg Elgar G. C. Chan Prabhu Arumugam Christine Patch Augusto Rendon David Bentley Clare Kingsley Jack A. Kosmicki Julie Horowitz Aris Baras Gonçalo R. Abecasis Manuel A. R. Ferreira Anne E. Justice Tooraj Mirshahi Matthew T. Oetjens Daniel J. Rader Marylyn D. Ritchie Anurag Verma Tom Fowler Manu Shankar‐Hari Charlotte Summers Charles Hinds Peter Horby Lowell Ling Daniel F. McAuley Hugh Montgomery Peter Openshaw Paul Elliott Timothy Walsh Albert Tenesa J. Kenneth Baillie Colin B. Begg Sara Clohisey Charles Hinds Peter Horby Julian C. Knight Lowell Ling David M. Maslove Daniel F. McAuley Johnny Millar Hugh Montgomery Alistair Nichol Peter Openshaw Alexandre C. Pereira Chris P. Ponting Kathy Rowan Malcolm G. Semple Manu Shankar‐Hari Charlotte Summers Timothy Walsh Latha Aravindan Ruth Armstrong Heather Biggs Ceilia Boz Adam Brown Richard E. Clark Audrey Coutts J. Terrence Coyle Louise Cullum Sukamal Das Nicky Day Lorna Donnelly Esther Duncan Angie Fawkes Paul Finernan Max Head Fourman Anita Furlong James Furniss

Abstract Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care 1 or hospitalization 2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics Mortality in Care) study enables comparison genomes from individuals who are critically ill those population controls to find underlying disease mechanisms. Here we use whole-genome sequencing 7,491 compared 48,400 discover and replicate 23...

10.1038/s41586-022-04576-6 article EN cc-by Nature 2022-03-07
Pierrick Wainschtein Deepti Jain Zhili Zheng Stella Aslibekyan Diane M. Becker and 95 more Wenjian Bi Jennifer A. Brody Jenna C. Carlson Adolfo Correa Margaret Mengmeng Du Lindsay Fernández‐Rhodes Kendra Ferrier Misa Graff Xiuqing Guo Jiang He Nancy L. Heard‐Costa Heather M. Highland Joel N. Hirschhorn Candace M Howard-Claudio Carmen R. Isasi Rebecca D. Jackson Jicai Jiang Roby Joehanes Anne E. Justice Rita R. Kalyani Sharon L. R. Kardia Ethan M. Lange Meryl S. LeBoff Seunggeun Lee Xihao Li Zilin Li Elise Lim D. Y. Lin Xihong Lin Simin Liu Yingchang Lu JoAnn E. Manson Lisa W. Martin Caitlin McHugh Julie Mikulla Solomon K. Musani Maggie Ng Deborah A. Nickerson Nicholette D. Palmer James A. Perry Ulrike Peters Michael Preuß Qibin Qi Laura M. Raffield Laura J. Rasmussen‐Torvik Alex P. Reiner Emily M. Russell Colleen M. Sitlani Jennifer A. Smith Cassandra N. Spracklen Tao Wang Zhe Wang Jennifer Wessel Hanfei Xu Mohammad Yaser Sachiko Yoneyama Kendra A. Young Jingwen Zhang Xinruo Zhang Hufeng Zhou Xiaofeng Zhu Sebastian Zoellner Namiko Abe Gonçalo R. Abecasis François Aguet Laura Almasy Álvaro Alonso Seth A. Ament Peter Anderson Pramod Anugu Deborah Applebaum‐Bowden Kristin Ardlie Dan E. Arking Allison E. Ashley‐Koch Tim Assimes Paul L. Auer Dimitrios Avramopoulos Najib Ayas Adithya Balasubramanian John Barnard Kathleen C. Barnes R. Graham Barr Emily Barron‐Casella Lucas Barwick Terri H. Beaty Gerald J. Beck Lewis C. Becker Rebecca Beer Amber L. Beitelshees Emelia J. Benjamin Takis Benos Marcos Bezerra Larry Bielak Joshua C. Bis Thomas W. Blackwell

10.1038/s41588-021-00997-7 article EN Nature Genetics 2022-03-01

<h3>Importance</h3> Detection of disease-associated variants in the<i>BRCA1</i>and<i>BRCA2</i>(<i>BRCA1/2</i>) genes allows for cancer prevention and early diagnosis high-risk individuals. <h3>Objectives</h3> To identify pathogenic likely (P/LP)<i>BRCA1/2</i>variants an unselected research cohort, to characterize the features associated with P/LP variants. <h3>Design, Setting, Participants</h3> This is a cross-sectional study adult volunteers (n = 50 726) who underwent exome sequencing at...

10.1001/jamanetworkopen.2018.2140 article EN cc-by-nc-nd JAMA Network Open 2018-09-21
Julie Horowitz Jack A. Kosmicki Amy Damask Deepika Sharma Genevieve H. L. Roberts and 95 more Anne E. Justice Nilanjana Banerjee Marie V. Coignet Ashish Yadav Joseph B. Leader Anthony Marcketta Danny S. Park Rouel Lanche Evan K. Maxwell Spencer C. Knight Xiaodong Bai Harendra Guturu Dylan Sun Asher K. Haug Baltzell Fabrício S. P. Kury Joshua Backman Ahna R. Girshick Colm O’Dushlaine Shannon McCurdy Raghavendran Partha Adam J. Mansfield David A. Turissini Alexander Li Miao Zhang Joelle Mbatchou Kyoko Watanabe Lauren Gurski Shane McCarthy Hyun Min Kang Lee Dobbyn Eli A. Stahl Anurag Verma Giorgio Sirugo Gonçalo R. Abecasis Michael Cantor Giovanni Coppola Andrew Deubler Aris N. Economides Katia Karalis Luca A. Lotta Alan R. Shuldiner Christina Beechert Caitlin Forsythe Erin D. Fuller Zhenhua Gu Michael Lattari Alexander Lopez Maria Sotiropoulos Padilla Manasi Pradhan Kia Manoochehri Thomas D. Schleicher Louis Widom Sarah E. Wolf Ricardo H. Ulloa Amelia Averitt Dadong Li Sameer Malhotra Jeffrey Staples Suying Bao Boris Boutkov Siying Chen Gisu Eom Alicia Hawes Shareef Khalid Olga Krasheninina Rouel Lanche Evan K. Maxwell George Mitra Mona Nafde Sean O’Keeffe Max Orelus Razvan Panea Tommy Polanco Ayesha Rasool Jeffrey G. Reid William Salerno Jeffrey Staples Kathie Sun Jiwen Xin Joshua Backman Manuel Allen Revez Ferreira Arkopravo Ghosh Christopher E. Gillies Eric Jorgenson Hyun Min Kang Michael D. Kessler Alexander Li Nan Lin Daren Liu Adam E. Locke Arden Moscati Charles Paulding Carlo Sidore Bin Ye Blair Zhang

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells via angiotensin-converting enzyme (ACE2) and causes disease 2019 (COVID-19). Here, through a genome-wide association study, we identify variant (rs190509934, minor allele frequency 0.2-2%) that downregulates ACE2 expression by 37% (P = 2.7 × 10-8) reduces the risk of SARS-CoV-2 infection 40% (odds ratio 0.60, P 4.5 10-13), providing genetic evidence levels influence COVID-19 risk. We also replicate...

10.1038/s41588-021-01006-7 article EN cc-by Nature Genetics 2022-03-03
Aldi T. Kraja Chunyu Liu Jessica L. Fetterman Mariaelisa Graff Henri Theil and 95 more C. Charles Gu Lisa R. Yanek Mary F. Feitosa Dan E. Arking Daniel I. Chasman Kristin L. Young Symen Ligthart W. David Hill Stefan Weiß Jian’an Luan Franco Giulianini Ruifang Li‐Gao Fernando Pires Hartwig Shiow J. Lin Lihua Wang Tom G. Richardson Jie Yao Eliana Portilla-Fernández Mohsen Ghanbari Mary K. Wojczynski Wen‐Jane Lee Maria Argos Sebastian M. Armasu Ruteja A. Barve Kathleen A. Ryan Ping An Thomas Baranski Suzette J. Bielinski Donald W. Bowden Ulrich Broeckel Kaare Christensen Audrey Y. Chu Janie Corley Simon R. Cox André G. Uitterlinden Fernando Rivadeneira Cheryl D. Cropp E. Warwick Daw Diana van Heemst Lisa de las Fuentes He Gao Ioanna Tzoulaki Tarunveer S. Ahluwalia Renée de Mutsert Leslie Emery A. Mesut Erzurumluoglu James A. Perry Mao Fu Nita G. Forouhi Zhenglong Gu Yang Hai Sarah E. Harris Gibran Hemani Steven C. Hunt Marguerite R. Irvin Anna Jonsson Anne E. Justice Nicola D. Kerrison Nicholas B. Larson Keng-Hung Lin Latisha Love‐Gregory Rasika A. Mathias Joseph H. Lee Matthias Nauck Raymond Noordam Ken K. Ong James S. Pankow Amit Patki Alison Pattie Astrid Petersmann Qibin Qi Rasmus Ribel‐Madsen Rebecca Rohde Kevin Sandow Theresia M. Schnurr Tamar Sofer John M. Starr Adele M. Taylor Alexander Teumer Nicholas J. Timpson Hugoline G. de Haan Yujie Wang Peter Weeke Christine A. Williams Hongsheng Wu Wei Yang Donglin Zeng Daniel R. Witte Bruce S. Weir Nicholas J. Wareham Henrik Vestergaard Stephen T. Turner Christian Torp‐Pedersen Evie Stergiakouli Wayne Huey‐Herng Sheu

Mitochondria (MT), the major site of cellular energy production, are under dual genetic control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear (MT-nDNA). In CHARGEmtDNA+ Consortium, we studied associations mtDNA MT-nDNA with body mass index (BMI), waist-hip-ratio (WHR), glucose, insulin, HOMA-B, HOMA-IR, HbA1c. This 45-cohort collaboration comprised 70,775 (insulin) to 170,202 (BMI) pan-ancestry individuals. Validation imputation variants was followed single-variant gene-based...

10.1016/j.ajhg.2018.12.001 article EN cc-by The American Journal of Human Genetics 2018-12-27
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