A5026017616- Congenital Heart Disease Studies
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Emergency and Acute Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Cardiac Structural Anomalies and Repair
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- interferon and immune responses
- Anesthesia and Neurotoxicity Research
- Infant Development and Preterm Care
- Heart Failure Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- Childhood Cancer Survivors' Quality of Life
- COVID-19 and healthcare impacts
- Global Maternal and Child Health
- Kawasaki Disease and Coronary Complications
- Renal function and acid-base balance
- Delphi Technique in Research
- Ultrasound in Clinical Applications
- Cardiovascular Issues in Pregnancy
Royal Children's Hospital
2016-2025
Murdoch Children's Research Institute
2016-2024
Australian and New Zealand Intensive Care Society
2018-2023
University of Edinburgh
2022-2023
The University of Melbourne
2013-2023
Roslin Institute
2022-2023
Eastern Health
2023
Intensive Care Society
2023
University of Zurich
2022
Osaka University
2020
Abstract Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care 1 or hospitalization 2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics Mortality in Care) study enables comparison genomes from individuals who are critically ill those population controls to find underlying disease mechanisms. Here we use whole-genome sequencing 7,491 compared 48,400 discover and replicate 23...
Objectives To assess the capacity of intensive care units (ICUs) in Australia to respond expected increase demand associated with COVID-19. Design Analysis Australian and New Zealand Intensive Care Society (ANZICS) registry data, supplemented by an ICU surge capability survey veterinary facilities (both March 2020). Settings All ICUs facilities. Main outcome measures Baseline numbers beds, ventilators, dialysis machines, extracorporeal membrane oxygenation intravenous infusion pumps, staff...
In children undergoing heart surgery, nitric oxide administered into the gas flow of cardiopulmonary bypass oxygenator may reduce postoperative low cardiac output syndrome, leading to improved recovery and shorter duration respiratory support. It remains uncertain whether improves ventilator-free days (days alive free from mechanical ventilation).
<h3>Importance</h3> Identification of potential indirect outcomes associated with the COVID-19 pandemic in pediatric population may be essential for understanding challenges current global public health crisis children and adolescents. <h3>Objective</h3> To investigate whether SARS-CoV-2 outbreak subsequent effective measures Australia were an increase admissions to intensive care units (ICUs) adolescents deliberate self-harm (DSH). <h3>Design, Setting, Participants</h3> This national,...
Monitoring healthcare quality is challenging in paediatric critical care due to measure variability, data collection burden, and uncertainty regarding consumer clinician priorities. We sought establish a core set that (i) meaningful consumers clinicians (ii) promotes alignment of use across care. conducted multi-stakeholder Delphi study with embedded prioritisation survey. The involved two surveys, followed by consensus meeting. Triangulation methods were used integrate survey findings prior...
We aimed to determine the effect of elective left heart decompression at time initiation central venoarterial extracorporeal membrane oxygenation (VA ECMO) on VA ECMO duration and clinical outcomes in children a single tertiary referral center with large pediatric population from national for cardiac surgery. studied 51 episodes historical cohort 49 patients treated between years 1990 2013 Paediatric Intensive Care Unit (PICU) Royal Children's Hospital, Melbourne. The cases had variety...
Objective: Outcomes for children with chronic critical illness are not defined. We examined the long-term survival of these in Australia and New Zealand. Design: All cases PICU length stay more than 28 days age 16 years old or younger Zealand from 2000 to 2011 were studied. Five-year was analyzed using Kaplan-Meir estimates, risk factors mortality evaluated Cox regression. Setting: PICUs Patients: Nine hundred twenty-four illness. Intervention: None. Measurements Main Results: admitted...
Objectives To describe the short term ability of Australian intensive care units (ICUs) to increase capacity in response heightened demand caused by COVID-19 pandemic. Design Survey ICU directors or delegated senior clinicians (disseminated 30 August 2021), supplemented and New Zealand Intensive Care Society (ANZICS) registry data. Setting All 194 public private ICUs. Main outcome measures Numbers currently available potentially beds case a surge; levels ICU-relevant equipment staff. Results...
Major postintensive care sequelae affect up to one in three adult survivors of critical illness. Large cohorts on educational outcomes after pediatric intensive are lacking. We assessed primary school a statewide cohort children who survived PICU during childhood.Multicenter population-based study less than 5 years admitted PICU. Using the National Assessment Program-Literacy and Numeracy database, outcome was achievement below Minimum Standard (NMS) year 3 school. Cases were compared with...
In 2023, the Australian and New Zealand Intensive Care Society (ANZICS) Registry run by Centre for Outcomes Resources Evaluation (CORE) turns 30 years old. It began with Adult Patient Database, Paediatric Registry, Critical it now includes Central Line Associated Bloodstream Infections Extra-Corporeal Membrane Oxygenation Health Information System. The ANZICS provides comparative case-mix reports, risk-adjusted clinical outcomes, process measures, quality of care indicators to over 200...
The capacity and limitations of ventricular assist device (VAD) support in single-ventricle physiology remains poorly understood. We aimed to review our experience the use VAD circulation determine its feasibility this population.We reviewed with patients single ventricles over past 25 years. Fifty-seven received 64 runs between 1990 2015 at a median age 13 days [interquartile range (IQR) 4.1-99.4 days], which 55 were supported for post-cardiotomy failure. majority short-term support, while...
Importance Children with congenital heart defects who undergo cardiopulmonary bypass (CPB) surgery are at risk for delayed or impaired neurodevelopmental outcomes. Nitric oxide (NO) added to the CPB oxygenator may reduce systemic inflammation due and improve recovery from surgery, including improved Objective To investigate neurodevelopment, health-related quality of life (HRQOL), factors associated neurodevelopment 12 months post in infants received NO standard CPB. Design, Setting,...
Abstract Objectives To investigate the influence of non‐medical social determinants health on rates admission and outcomes for children admitted to intensive care units (ICUs) in Australia. Study design Retrospective cohort study; analysis Australian New Zealand Paediatric Intensive Care Registry data. Setting, participants Children (18 years or younger) ICUs during 1 January 2013 – 31 December 2020. Main outcome measures Population‐standardised ICU rates, overall by residential...
Objectives: To assess the feasibility, safety, and efficacy of a sedation protocol using dexmedetomidine as primary sedative in mechanically ventilated critically ill children. Design: Open-label, pilot, prospective, multicenter, randomized, controlled trial. The outcome was proportion scores target range first 48 hours. Safety outcomes included device removal, adverse events, vasopressor use. Feasibility time to randomization fidelity. Setting: Six tertiary PICUs Australia New Zealand....
Whilst survival in paediatric critical care has improved, clinicians lack tools capable of predicting long-term outcomes. We developed a machine learning model to predict poor school outcomes children surviving intensive unit (ICU).
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 COVID-19 cases 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 present 2.4% young (<60 years) no reported clinical (n = 378), compared 0.24% (odds ratio [OR] 12.3, p 1.27 × 10
Despite the challenges posed by vast geographical distances and relatively small populations (Australia: 26 million, New Zealand: 5 million), Australia Zealand (ANZ) are renowned for their high quality innovative pediatric intensive care research. A strong culture of partnership across units led to formation ANZ Intensive Care Society Paediatric Study Group (ANZICS PSG) in 2003, which has evolved since its into one leading international trial networks, along with two United States (1,2)...
To determine the cardiovascular tolerance of clonidine used as a first-line sedative after cardiac surgery in small infants.Retrospective chart review.A tertiary and quaternary referral PICU.All infants younger than 2 months who received infusion for sedation from October 2011 to July 2013.None.Heart rate, blood pressure, central venous left atrial vasoactive inotropic score, volume fluid bolus, lactate mixed saturation were assessed. Preinfusion values compared with postinfusion values. Of...