Gérard Cortina
A5076766928- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Cardiac Arrest and Resuscitation
- Complement system in diseases
- Mechanical Circulatory Support Devices
- Central Venous Catheters and Hemodialysis
- Renal function and acid-base balance
- Renal Diseases and Glomerulopathies
- Hemodynamic Monitoring and Therapy
- Electrolyte and hormonal disorders
- Renal Transplantation Outcomes and Treatments
- Respiratory Support and Mechanisms
- Blood groups and transfusion
- Intensive Care Unit Cognitive Disorders
- Heart Failure Treatment and Management
- Vitamin D Research Studies
- Blood Pressure and Hypertension Studies
- Anesthesia and Sedative Agents
- Bacterial Infections and Vaccines
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects and Toxicity Studies
- Neonatal Health and Biochemistry
- Potassium and Related Disorders
- Adolescent and Pediatric Healthcare
Innsbruck Medical University
2015-2024
Universität Innsbruck
2016-2024
Royal Children's Hospital
2016-2023
Meyer Children's Hospital
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Children's Mercy Hospital
2023
Hospital for Sick Children
2021
Medeniyet Üniversitesi Göztepe Eğitim ve Araştırma Hastanesi
2018
Intensive Care Society
2017
Erasmus MC - Sophia Children’s Hospital
2016
Summary Background and objectives This study evaluated the relevance of complement factor H (CFH)–related protein (CFHR) 1 deficiency in pediatric patients with atypical hemolytic uremic syndrome (aHUS) by evaluating both frequency deletions CFHR1 presence (CFH) antibodies. Design, setting, participants, & measurements A total 116 (mainly from central Europe) 118 healthy blood donors were included 2001 to 2012. The gene was determined 90 aHUS controls an easy, fast, cheap PCR assay; 100...
Steroid-resistant focal segmental glomerulosclerosis (FSGS) often recurs after renal transplantation. In this international survey, we sought to identify genotype–phenotype correlations of recurrent FSGS. We surveyed 83 patients with childhood-onset primary FSGS who received at least one allograft and analyzed 53 these for NPHS2 mutations. The mean age diagnosis was 6.7 years, the first transplantation 13 years. recurred in 30 (36%) a median days (range, 1.5 152 days). Twenty-three second...
Continuous kidney replacement therapy (CKRT) is the preferred method of support for children with critical illness in pediatric intensive care units (PICUs). However, there are no data on current CKRT management practices European PICUs.To describe across PICUs.This cross-sectional survey PICUs 20 countries was conducted by Critical Care Nephrology Section Society Pediatric and Neonatal Intensive from April 1, 2020, to May 31, 2022. Participants included intensivists nurses working PICUs....
Continuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small single center in design. Large international studies evaluating practice outcomes lacking. Herein, we describe design a multinational collaborative.
Importance Continuous kidney replacement therapy (CKRT) is increasingly used in youths with critical illness, but little known about longer-term outcomes, such as persistent dysfunction, continued need for dialysis, or death. Objective To characterize the incidence and risk factors, including liberation patterns, associated major adverse events 90 days after CKRT initiation (MAKE-90) children, adolescents, young adults. Design, Setting, Participants This international, multicenter cohort...
In clinical trials, the early or accelerated continuous renal replacement therapy (CRRT) initiation strategy among adults with acute kidney injury volume overload has not demonstrated a survival benefit. Whether timing of CRRT is associated outcomes children and young unknown.
Objective: To identify risk factors associated with mortality in critically ill children requiring continuous renal replacement therapy. Design: Retrospective observational study based on a prospective registry. Setting: Tertiary and quaternary referral 30-bed PICU. Patients: Critically undergoing therapy were included the study. Interventions: Continuous Measurements Main Results: Overall was 36% ( n = 58) among 161 patients treated during period significantly higher extracorporeal membrane...
Abstract Background Hemolytic uremic syndrome (HUS) is an important cause of acute kidney injury in children. HUS known as disease followed by complete recovery, but patients may present with abnormalities after long periods time. This study evaluates the long-term outcome Shiga toxin-producing Escherichia coli -associated (STEC-HUS) pediatric patients, 10 years phase to identify risk factors for sequelae. Methods Over a 6-year period, 619 under 18 age (490 STEC-positive, 79%) were...
OBJECTIVES: Pediatric sepsis-associated acute kidney injury (AKI) often requires continuous renal replacement therapy (CRRT), but limited data exist regarding patient characteristics and outcomes. We aimed to describe these features, including the impact of possible dialytrauma (i.e., vasoactive requirement, negative fluid balance) on outcomes, contrast them nonseptic patients in an international cohort children young adults receiving CRRT. DESIGN: A secondary analysis Worldwide Exploration...
Objective: To characterize the clinical indications, procedural safety, and outcome of critically ill children requiring therapeutic plasma exchange. Design: Retrospective observational study based on a prospective registry. Setting: Tertiary quaternary referral 30-bed PICU. Patients: Forty-eight who received exchange during an 8-year period (2007–2014) were included in study. Interventions: Therapeutic Measurements Main Results: A total 48 patients underwent 244 sessions. Of those, was...
We investigated the effects of nutritional vitamin D supplementation on markers bone and mineral metabolism, i.e. serum levels fibroblast growth factor 23 (FGF23), Klotho, alkaline phosphatase (BAP) sclerostin, in two cohorts with chronic kidney disease (CKD).In all, 80 D-deficient children were selected: 40 mild to moderate CKD from ERGO study, a randomized trial ergocalciferol [estimated glomerular filtration rate (eGFR) 55 mL/min/1.73 m2], advanced observational Cardiovascular Comorbidity...
Background Carotid intima‐media thickness (cIMT) may identify early alterations in the vascular phenotype children with chronic kidney disease (CKD). Methods and Results Investigation of longitudinal changes cIMT SD scores (SDS) 670 patients from 4C Study (Cardiovascular Comorbidity Children With CKD Study), aged 6 to 17 years, stage 3 5 at baseline. The trajectory SDS over up 8 years was examined using a mixed‐effects model. yearly progression rate (β=0.20 [95% CI, 0.13–0.28]) remained...
Abstract Background and Hypothesis Mortality rates of children supported with continuous renal replacement therapy (CRRT) have improved, yet morbidity remains high. We aimed to evaluate the functional outcomes receiving CRRT using status scale (FSS). hypothesized that will worse FSS compared their baseline, acquire new at hospital discharge 6-and 12-months post discharge, lack recovery contribute worsening status. Methods This is a retrospective chart review from The Worldwide Exploration...
Abstract Background Therapeutic plasma exchange (TPE) has evolved to an accepted therapy for selected indications. However, it is technically challenging in children. Moreover, data on safety and efficacy are mainly derived from adult series. The aim of this study was review the procedure context clinical indications, effectiveness, safety. Study Design Methods All TPE procedures performed at a tertiary care hospital during 12‐year period (2005–2016) were retrospectively evaluated. Results...
To determine the cardiovascular tolerance of clonidine used as a first-line sedative after cardiac surgery in small infants.Retrospective chart review.A tertiary and quaternary referral PICU.All infants younger than 2 months who received infusion for sedation from October 2011 to July 2013.None.Heart rate, blood pressure, central venous left atrial vasoactive inotropic score, volume fluid bolus, lactate mixed saturation were assessed. Preinfusion values compared with postinfusion values. Of...
Scores can assess the severity and course of disease predict outcome in an objective manner. This information is needed for proper risk assessment stratification. Furthermore, scoring systems support optimal patient care, resource management are gaining importance terms artificial intelligence.This study evaluated compared prognostic ability various common pediatric (PRISM, PRISM III, IV, PIM, PIM2, PIM3, PELOD, PELOD 2) order to determine which most applicable score sepsis patients timing...
To examine the effects of patient and treatment variables on circuit lifespan in critically ill children requiring continuous renal replacement therapy.Retrospective observational study based a prospective registry.Tertiary referral 30-bed PICU.One hundred sixty-one undergoing therapy during an 8-year period (2007-2014) were included study.Continuous therapy.During period, 161 patients received total 22,190 hours therapy, with median duration 74.75 (interquartile range, 32-169.5) per...
To describe the effect of extracorporeal membrane oxygenation (ECMO) on survival and cardiac outcome neonates with myocardial failure secondary to severe enterovirus (EV) myocarditis.Retrospective case series.A 15-bed paediatric intensive care unit (ICU).We clinical presentations, findings, ECMO characteristics seven EV myocarditis. Additionally, 35 previously reported cases myocarditis supported are presented.Extracorporeal oxygenation.Seven presented cardiovascular collapse within first 10...