Marcin Tkaczyk
A5072258018- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Dialysis and Renal Disease Management
- Urological Disorders and Treatments
- Renal and related cancers
- Adolescent and Pediatric Healthcare
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Parathyroid Disorders and Treatments
- Acute Kidney Injury Research
- Genetic and Kidney Cyst Diseases
- Birth, Development, and Health
- Renal function and acid-base balance
- Platelet Disorders and Treatments
- Urinary Tract Infections Management
- Electrolyte and hormonal disorders
- Childhood Cancer Survivors' Quality of Life
- Biomedical Research and Pathophysiology
- Neonatal Respiratory Health Research
- Kidney Stones and Urolithiasis Treatments
- Central Venous Catheters and Hemodialysis
- Blood Pressure and Hypertension Studies
- Genetic Syndromes and Imprinting
- Autoimmune Bullous Skin Diseases
- Chronic Kidney Disease and Diabetes
- Urinary Bladder and Prostate Research
Medical University of Silesia
2025
Polish Mother’s Memorial Hospital Research Institute
2015-2024
Medical University of Lodz
2014-2024
Children's Memorial Health Institute
2020-2023
University of Manchester
2019
Devices for Dignity
2019
KU Leuven
2019
Jagiellonian University
2014-2018
University of Łódź
2018
Medical University of Warsaw
2018
Growth references are useful in monitoring a child's growth, which is an essential part of child care. The aim this paper was to provide updated growth for Polish school-aged children and adolescents show the prevalence overweight obesity among them. height, weight, body mass index (BMI) were constructed with lambda, mu, sigma (LMS) method using data from recent, large, population-representative sample Poland (n = 17,573). according International Obesity Taskforce definition determined use...
We investigated the value of genetic, histopathologic, and early treatment response information in prognosing long-term renal outcome children with primary steroid-resistant nephrotic syndrome. From PodoNet Registry, we obtained longitudinal clinical for 1354 patients (disease onset at >3 months <20 years age): 612 had documented responsiveness to intensified immunosuppression (IIS), 1155 kidney biopsy results, 212 an established genetic diagnosis. assessed risk factors ESRD using...
The efficacy of continuous antibiotic prophylaxis in preventing urinary tract infection (UTI) infants with grade III, IV, or V vesicoureteral reflux is controversial. Download a PDF the Research Summary. In this investigator-initiated, randomized, open-label trial performed 39 European centers, we randomly assigned 1 to 5 months age and no previous UTIs receive (prophylaxis group) treatment (untreated for 24 months. primary outcome was occurrence first UTI during period. Secondary outcomes...
The DiGeorge syndrome, the most common of microdeletion syndromes, affects multiple organs, including heart, nervous system, and kidney. It is caused by deletions on chromosome 22q11.2; genetic driver kidney defects unknown.
Primary Coenzyme Q10 (CoQ10) deficiency is an ultra-rare disorder caused by defects in genes involved CoQ10 biosynthesis leading to multidrug-resistant nephrotic syndrome as the hallmark kidney manifestation. Promising early results have been reported anecdotally with oral supplementation. However, long-term efficacy and optimal prescription remain be established. In a global effort, we collected analyzed information from 116 patients who received supplements for primary due biallelic...
Abstract Background The growth of children is an indicator health and society's wellbeing. Growth references are useful in monitoring a child's growth, which very important part child care. Poland's not updated regularly. Although several reference ranges have been developed Poland over recent years, sampling was restricted to urban populations major cities. aim this study assess how well Polish match with, or diverge from, regional charts compare them with international references. Methods...
Abstract Background Currently used pediatric kidney length normative values are based on small single-center studies, do not include function assessment, and focus mostly newborns infants. We aimed to develop ultrasound-based derived from a large group of European Caucasian children with normal function. Methods Out 1,782 aged 0–19 years, 1,758 individuals no present or past disease estimated glomerular filtration rate had sonographic assessment length. The results were correlated...
The aim of the study was to analyse health-related quality life (HRQoL) in Polish children with chronic kidney disease (CKD) dependant on CKD stage, treatment modality and selected social elements families patients. Furthermore, potential differences between self-report parent/proxy reports factors influencing them were assessed. A total 203 (on haemodialysis (HD), peritoneal dialysis (PD) conservative (CT)) their 388 parent/proxies enrolled into a cross-sectional national study. demographic...
The aim of the study was to assess idiopathic nephrotic syndrome (INS) relapse rate, co-morbidities, and social status adults diagnosed with INS in childhood.A written questionnaire sent 118 treated for childhood. In 61 (51.7%) responders (aged 26.0 ± 6.2 years, range 18 - 51.5 years), we used available medical records evaluate age at onset INS, number relapses below years age, response corticosteroids (CS), renal biopsy findings, immunosuppressive treatment as well above menarche, marital...
There are three principle forms of vascular access available for the treatment children with end stage kidney disease (ESKD) by haemodialysis: tunnelled catheters placed in a central vein (central venous lines, CVLs), arteriovenous fistulas (AVF), and grafts (AVG) using prosthetic or biological material. Compared adult literature, there few studies to provide evidence based guidelines optimal type its management outcomes ESKD.The European Society Paediatric Nephrology Dialysis Working Group...
The aim of this study was to analyze psychosocial aspects chronic kidney disease (CKD) in children treated with automated peritoneal dialysis (APD).The assessed 41 > 2 (range 2.1-18) years age and their parents. Data concerning the illness sociodemographic parameters were collected. Patients completed Paediatric Quality Life Inventory (PedsQL) parents PedsQL-proxy version, General Health Questionnaire (GHQ-12), Berlin Social Support Scales (BSSS), Caregiver's Burden Scale (CBS).Parents rated...
Significance Statement Vesicoureteral reflux (VUR) is associated with progressive kidney disease. Familial aggregation supports a hereditary basis; however, its genetic architecture remains to be elucidated. The largest VUR copy number variant analysis and genome-wide association study date accounts for multiple modes of inheritance sex-specific effects in VUR, identifying three study-wide significant five suggestive loci large effects, containing canonical developmental genes including...
Background. The aim of this nationwide analysis was to assess the incidence and current treatment profile arterial hypertension in children undergoing chronic haemodialysis or peritoneal dialysis attitudes paediatric nephrologists towards choice antihypertensive drugs their patients.
Endothelial function impairment may constitute a link between nephrotic syndrome and atherosclerosis. We assessed changes in plasma thrombomodulin, von Willebrand factor plasminogen activator inhibitor-1 at different stages of idiopathic children correlated them with clinical biochemical parameters. The study group included 132 (aged 2-18 years) divided into four groups, i.e. acute phase the disease proteinuria, during steroid-induced remission, steroid-free long-term, remission. Forty-one...
Acute renal failure (ARF) is still a frequent complication following extensive cardiac surgery. Renal replacement therapy (RRT) modality preferences to treat critically ill children have shifted from peritoneal dialysis continuous (CRRT), although the experience with latter highly limited in infants.We describe our results veno-venous hemodiafiltration (CVVHDF) 25 (15 males, 10 females) who underwent CRRT 2001 2006 and were retrospectively reviewed.We performed (CVHDF) using PRISMA (Hospal)....
We investigated the effects of nutritional vitamin D supplementation on markers bone and mineral metabolism, i.e. serum levels fibroblast growth factor 23 (FGF23), Klotho, alkaline phosphatase (BAP) sclerostin, in two cohorts with chronic kidney disease (CKD).In all, 80 D-deficient children were selected: 40 mild to moderate CKD from ERGO study, a randomized trial ergocalciferol [estimated glomerular filtration rate (eGFR) 55 mL/min/1.73 m2], advanced observational Cardiovascular Comorbidity...
Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management PUV is prenatal prediction postnatal function. Fetal ultrasound and fetal urine biochemistry are currently employed this prediction, but clearly lack precision. We previously developed a peptide signature that predicted utero with high precision function fetuses PUV. describe here objectives design prospective international multicentre ANTENATAL (multicentre validation...
Background: The study aimed to determine the differences between COVID-19 and Respiratory syncytial virus (RSV) infections in young children hospitalized pediatric department. Methods: This retrospective included 52 with 43 RSV infection younger than 36 months a department September 2021 March 2022. Clinical laboratory findings, methods of treatment hospitalization length were compared. Results: In group, significantly higher rates cough (93.2% vs. 38.5%), rhinitis (83.7% 50%), dyspnea...