A5041378698- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Central Venous Catheters and Hemodialysis
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- Muscle and Compartmental Disorders
- Ion Transport and Channel Regulation
- Complement system in diseases
- Pediatric Urology and Nephrology Studies
- Pregnancy and Medication Impact
- Body Composition Measurement Techniques
- Escherichia coli research studies
- Adolescent and Pediatric Healthcare
- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Biomedical Research and Pathophysiology
- Electrolyte and hormonal disorders
- Renal and Vascular Pathologies
- Renal and related cancers
- Renal function and acid-base balance
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Kidney Disease and Diabetes
- Viral gastroenteritis research and epidemiology
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016-2025
University of Milan
2001-2020
Ospedale Maggiore
2007-2017
Istituti di Ricovero e Cura a Carattere Scientifico
1992-2017
Great Ormond Street Hospital
2017
University College London
2017
University of Bari Aldo Moro
1993-2009
Istituto Giannina Gaslini
1988-2009
Università Cattolica del Sacro Cuore
2004-2009
University of Foggia
2009
The ItalKid Project is a prospective, population-based registry that was started in 1990 with the aim of assessing epidemiology childhood chronic renal failure (CRF), describing natural history disease, and identifying factors influence its course. This article reports epidemiologic results.Prevalent incident cases CRF children adolescents were identified throughout Italy (total population base: 16.8 million children) by regularly asking all pediatric hospitals adult nephrology units...
Prednisone and calcineurin inhibitors are the mainstay therapy of idiopathic nephrotic syndrome (INS) in children. However, drug dependence toxicity associated with protracted use common. Case series suggest that anti-CD20 monoclonal antibody rituximab (RTX) may maintain disease remission.This open-label randomized controlled trial was powered to show a strategy based on RTX lower doses prednisone noninferior standard these agents maintaining 3-month proteinuria as low baseline or up 1 g/d...
Abstract The mean annual incidence of hemolytic uremic syndrome in persons <15 years age Italy from 1988 to 2000 was 0.28 per 100,000 population. Laboratory investigations showed that Shiga toxin–producing Escherichia coli (STEC) infection occurred 73.1% patients. STEC O157 the most common serotype, but a considerable number cases were infections by non-O157 STEC.
Journal Article Communitywide Outbreak of Hemolytic-Uremic Syndrome Associated with Non-O157 Verocytotoxin-Producing Escherichia coli Get access Alfredo Caprioli, Caprioli Reprints or correspondence: Dr. Laboratorio di Ultrastrutture, Istituto Superiore San Sta. Viale Regina Elena 299, 00161 Rome, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ida Luzzi, Luzzi Francesco Rosmini, Rosmini Carlo Resti, Resti Alberto Edefonti, Edefonti Perfumo, Perfumo...
Steroid-dependent nephrotic syndrome (SDNS) carries a high risk of toxicity from steroids or steroid-sparing agents. This open-label, noninferiority, randomized controlled trial at four sites in Italy tested whether rituximab is noninferior to maintaining remission juvenile SDNS. We enrolled children age 1-16 years who had developed SDNS the previous 6-12 months and were maintained with prednisone doses (≥0.7 mg/kg per day). randomly assigned participants continue alone for 1 month (control)...
Idiopathic nephrotic syndrome resistant to standard treatments remains a therapeutic dilemma in pediatric nephrology. To test whether the anti-CD20 monoclonal antibody rituximab may benefit these patients, we conducted an open-label, randomized, controlled trial 31 children with idiopathic unresponsive combination of calcineurin inhibitors and prednisone. All continued prednisone at doses prescribed before enrollment, one treatment group received two (375 mg/m(2) intravenously) as add-on...
Very young children with chronic kidney disease often have difficulty maintaining adequate nutrition, which contributes to the high prevalence of short stature in this population. Characteristics dialysis prescription and supplemental feeding via a nasogastric (NG) tube or gastrostomy may improve growth, but is not well understood. Here, we analyzed data from 153 18 countries who commenced peritoneal at <24 months age. From diagnosis last observation, 57 patients were fed on demand, 54 by NG...
Background Growth charts based on data collected in different populations and time periods are key tools to assess children’s linear growth. We analyzed the impact of geographic factors secular trend height-for-age currently used European populations, developed up-to-date growth charts, studied effect using a sample retarded children. Methods Findings In an international survey we obtained 18 unique national from 28 countries compared them with World Health Organization (WHO), Euro-Growth...
Vitamin D deficiency is widely prevalent and often severe in children adults with chronic kidney disease (CKD). Although native vitamin {25-hydroxyvitamin [25(OH)D]} thought to have pleiotropic effects on many organ systems, its skeletal been most studied. The 25(OH)D causally linked rickets fractures healthy those CKD, contributing the CKD–mineral bone disorder (MBD) complex. There are few studies provide evidence for therapy or guidelines use CKD. A core working group (WG) of European...
To compare the efficacy (maintenance of remission), safety and tolerability cyclosporin (CsA) with those cyclophosphamide in patients steroid-dependent or frequently relapsing nephrotic syndrome (NS). Open, prospective, randomized, multicentre, controlled study for parallel groups, stratified adults children. The setting was nephrological departments Italy. Seventy-three steroid-sensitive idiopathic NS admitted to were randomly assigned (2.5 mg/kg/day) 8 weeks CsA (5 mg/kg/day adults, 6...
Journal Article Purpura of the ears: a distinctive vasculopathy with circulating autoantibodies complicating long‐term treatment levamisole in children Get access F Rongioletti, Rongioletti DISEM, Section Dermatology, University Genoa, Italy, Search for other works by this author on: Oxford Academic Google Scholar L Ghio, Ghio Division Nephrology, Paediatric Clinic, Milan, Ginevri, Ginevri D Bleidl, Bleidl S Rinaldi, Rinaldi Bambin Gesù Hospital, Rome, Italy A Edefonti, Edefonti C Gambini,...
To provide recommendations for the care of infants with stage 5 chronic kidney disease (CKD5). European Paediatric Dialysis Working Group. Literature on clinical studies involving CKD5 (end renal failure) and consensus discussions within group. There has been an important change in attitudes towards offering RRT (renal replacement therapy) to both newborns as data have accumulated their improved survival long-term outcomes. The management this challenging group patients differs a number ways...
In patients with chronic kidney disease (CKD), renal synthesis of active vitamin D [1,25-dihydroxyvitamin (1,25(OH)2D)] declines and is associated hypocalcaemia, secondary hyperparathyroidism the spectrum CKD–mineral bone disorder (MBD). advanced CKD, analogues, including alfacalcidol, calcitriol paricalcitol, are routinely administered. There few studies on use analogues in children CKD dialysis. It difficult to define bone-specific outcomes that can guide treatment CKD-MBD. A core working...
The therapeutic effect of plasma infusion was evaluated in 10 children and seven adults with haemolytic uraemic syndrome. All but one patient responded to this treatment rapid disappearance haematological abnormalities. who apparently failed respond obtained complete remission the disease after plasmapheresis. Although 15 17 patients were anuric or oliguric on admission, renal function recovered completely eight two adults. Seven showed residual chronic failure required long-term maintenance...
Intestinal infections with Shiga toxin-producing Escherichia coli (STEC) in children can lead to the hemolytic uremic syndrome (HUS). toxins (Stx) released gut by bacteria enter blood stream and target kidney causing endothelial injury. Free have never been detected of HUS patients, but they found on surface polymorphonuclear leukocytes (PMN).With respect their clinical features, relevance amounts serum Stx (cytotoxicity assay human cells) PMN-bound (cytofluorimetric assay) 46 patients...
The prevalence of childhood overweight is rising worldwide, but in children on renal replacement therapy (RRT) a poor nutritional status still the primary concern. We aimed to study of, and factors associated with, underweight overweight/obesity European paediatric RRT population. Moreover, we assessed evolution body mass index (BMI) after start RRT. included 4474 patients younger than 16 years from 25 countries whom BMI data, obtained between 1995 2010, were available within Society for...
Although chronic peritoneal dialysis (CPD) is considered the replacement therapy of choice for infants with end-stage renal failure, many questions persist about treatment risks and outcomes.We present data on 84 who started CPD at <1 year age; these patients represent 12% total population Italian Registry Paediatric Chronic Dialysis. We analysed patient records from all children consecutively treated between 1995 2007 in Italy. Growth analysis was performed only complete auxological...