A5046831832- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Pediatric Urology and Nephrology Studies
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Inhalation and Respiratory Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Child Nutrition and Feeding Issues
- Respiratory viral infections research
- Metabolism and Genetic Disorders
- Pneumonia and Respiratory Infections
- Dialysis and Renal Disease Management
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Nematode management and characterization studies
- Mycobacterium research and diagnosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vascular anomalies and interventions
- Diet and metabolism studies
- Autoimmune and Inflammatory Disorders Research
- Bacterial Infections and Vaccines
- Complement system in diseases
- Pneumocystis jirovecii pneumonia detection and treatment
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2014-2025
University of Milan
1999-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2004-2023
Ospedale Maggiore
2004-2023
Ospedale San Giuseppe
2021
Cystic Fibrosis Research Foundation
2011-2019
Policlinico San Matteo Fondazione
2004
University Hospital Heidelberg
2000
Heidelberg University
2000
Istituti Clinici di Perfezionamento
1999
The ItalKid Project is a prospective, population-based registry that was started in 1990 with the aim of assessing epidemiology childhood chronic renal failure (CRF), describing natural history disease, and identifying factors influence its course. This article reports epidemiologic results.Prevalent incident cases CRF children adolescents were identified throughout Italy (total population base: 16.8 million children) by regularly asking all pediatric hospitals adult nephrology units...
Abstract Background Elexacaftor‐tezacaftor‐ivacaftor (ETI) is a highly effective cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulating therapy for people with CF and at least one F508del variant. However, there limited data about the safety efficacy of this in pediatric populations real‐world settings. This study aimed evaluating effectiveness, tolerability, ETI children CF. Methods was prospective observational including all aged 6–11 years who initiated between October...
To analyse the timing of end stage renal disease in children with chronic kidney (CKD).A population-based cohort study.A nationwide registry (ItalKid Project) collecting information on all patients CKD aged <20 years.935 secondary to hypodysplasia or without urologic malformation. In a subgroup (n=40) detailed pubertal staging was analysed relation progression.Kidney survival (KS) estimated using replacement therapy (RRT) as end-point. Puberty staged by identifying growth spurt.A non-linear...
No AccessJournal of UrologyPediatric Urology1 Jul 2004LONG-TERM OUTCOME OF VESICOURETERAL REFLUX ASSOCIATED CHRONIC RENAL FAILURE IN CHILDREN. DATA FROM THE ITALKID PROJECT GIANLUIGI ARDISSINO, LUIGI AVOLIO, VALERIA DACCO, SARA TESTA, GIUSEPPINA MARRA, VIGANÒ, SILVANA LOI, PAOLO CAIONE, ROBERTO DE CASTRO, SALVATORE PASCALE, EFISIA MARRAS, GIOVANNA RICCIPETITONI, GIORGIO SELVAGGIO, PAOLA PEDOTTI, ALDO CLARIS-APPIANI, ANTONIO CIOFANI, LUCA DELLO STROLOGO, GIULIANA LAMA, GIOVANNI MONTINI, and...
Background: To limit the progression of disease, people with cystic fibrosis (pwCF) perform daily respiratory physiotherapy, which is perceived as most burdensome routine in managing their condition. The elexacaftor–tezacaftor–ivacaftor (ETI) combination has changed management. Objective: investigate how treatment burden 1 year ETI. Design: Prospective observational study. Methods: Ad hoc questionnaires for pwCF and caregivers < 18 years were administered before initiation ETI therapy...
Background. Chronic kidney diseases (CKD) tend to progress end-stage renal failure (ESRF). As it has been demonstrated that angiotensin-converting enzyme inhibitors (ACEi) have a renoprotective effect in adults with proteinuric disease and may be effective reducing hyperfiltration proteinuria, they are also frequently used as anti-progression agents paediatric patients CKD despite the lack of data confirming their role nephropathies peculiar children. The aim this study was investigate...
Cystic Fibrosis (CF) lung disease is characterized by high levels of cytokines and chemokines in the airways, producing chronic inflammation. Non-invasive biomarkers, which are also specific for inflammatory immune responses, urgently needed to identify exacerbations evaluate therapeutic efficacy. The aim this study association sputum exhaled breath condensate (EBC) biomarker changes with clinical exacerbation response therapy. We studied simultaneous presence concentration twelve growth...
The question whether the new cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs aimed at restoring CFTR protein function might improve glucose metabolism is gaining attention, but data on effect of lumacaftor/ivacaftor treatment (LUMA/IVA) tolerance are limited. We evaluated variation in and insulin secretion CF patients homozygous for Phe508del mutation after one-year with LUMA/IVA comparison to same genotype who did not receive such treatment.We performed a...
Diabetes frequently complicates cystic fibrosis (CF) without fasting hyperglycemia or despite spontaneous hypoglycemia (anecdotally ascribed to malnutrition), whose prevalence, clinical meaning, and relationship with glucose tolerance clinical/nutritional status were not previously investigated. The of CF genotype insulin secretion control is also unclear.A total 129 patients stable diabetes received 188 oral tests. Distribution plasma (FPG), glucose, C-peptide responses, variables, their...
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a serious life-treating condition characterized by skin eruption, fever, haematologic abnormalities, multi-organ involvement that can be fatal if unrecognized, especially in patients liver failure. Diagnosis may difficult because it rarely described children mimic many different conditions. We report two cases of DRESS due to prolonged antibiotic treatment young whom recovery occurred following therapeutic approaches....
Objective To describe the symptoms and clinical course of SARS-CoV-2 infection in patients with cystic fibrosis (CF). Methods We carried out a prospective multicentre cohort study based on 32 CF centres 6597 patients. Centres were contacted to collect baseline follow-up data who reported suggestive COVID-19 or had contact positive/suspected case between end February July 2020. Symptoms compared tested positive by molecular testing (cases) those negative (controls). Results Thirty from...
Antimicrobial resistance (AMR) poses a major threat to human health globally. Approximately 5 million deaths were attributed AMR in 2019, and this figure is predicted worsen, reaching 10 by 2050. In the search for new compounds that can tackle AMR, FtsZ inhibitors represent valuable option. present study, structure-based virtual screening reported, which led identification of derivative C11 endowed with an excellent minimum inhibitory concentration value 2 μg/mL against Staphylococcus...
Growth retardation commonly complicates chronic renal failure in children. Although the etiology of this growth impairment is multifactorial, inadequate nutrition considered an important cause infants and young An “aggressive” nutritional approach has been repeatedly suggested children with early onset poor feeding habits, but possibility inducing catch‐up by energy supplementation still controversial. The effects a long‐term, home‐based enteral program were studied two three moderate to...