A5053491148- Apelin-related biomedical research
- Cardiac Ischemia and Reperfusion
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Asthma and respiratory diseases
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Cystic Fibrosis Research Advances
- Cardiac Arrest and Resuscitation
- Paraoxonase enzyme and polymorphisms
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Electrospun Nanofibers in Biomedical Applications
- Nitric Oxide and Endothelin Effects
- Electrical and Bioimpedance Tomography
- Adenosine and Purinergic Signaling
- Anesthesia and Neurotoxicity Research
- Tuberculosis Research and Epidemiology
- Transplantation: Methods and Outcomes
- Fatty Acid Research and Health
- Respiratory Support and Mechanisms
- Receptor Mechanisms and Signaling
- Mycobacterium research and diagnosis
Sahlgrenska University Hospital
2024
University of Turin
2012-2022
Ospedale Regina Margherita
2020-2021
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2021
Monash University
2020
Ospedale San Luigi Gonzaga
2011-2015
Istituto Nazionale per le Ricerche Cardiovascolari
2010
Information on the clinical traits associated with bronchial neutrophilia in asthma is scant, preventing its recognition and adequate treatment. We aimed to assess clinical, functional biological features of neutrophilic identify possible predictors neutrophilia.The inflammatory phenotype 70 mild-to-severe patients was studied cross-sectionally based eosinophilic/neutrophilic counts their lamina propria. Patients were classified as or non-neutrophilic. Neutrophilic (neutrophil count cut-off:...
In vivo IL-17A activity is elevated in active tuberculosis and may be a therapeutic target to attenuate disease-associated immunopathology.
There are few studies providing a more comprehensive picture of advanced hybrid closed-loop (AHCL) systems in clinical practice. The aim was to evaluate the effects AHCL systems, Tandem
We studied whether apelin-13 is cardioprotective against ischemia/reperfusion injury if given as either a pre- or postconditioning mimetic and the improved postischemic mechanical recovery induced by depends only on reduced infarct size also of function viable myocardium. nitric oxide (NO) involved in apelin-induced protection reported ischemia-induced overexpression apelin receptor (APJ) plays role cardioprotection. Langendorff-perfused rat hearts underwent 30 min global ischemia 120...
Depending on their concentrations, both nitric oxide (NO) and reactive oxygen species (ROS) take part either in myocardial ischemia reperfusion injury or protection by ischemic pharmacological preconditioning (Ipre) postconditioning (Ipost). At the beginning of reperfusion, a transient release NO is promptly scavenged ROS to form highly toxic peroxynitrite, which responsible for further increase through endothelial synthase uncoupling. The protective role has suggested use donors mimic Ipre...
Apelin, the ligand of G-protein-coupled receptor (GPCR) APJ, exerts a post-conditioning-like protection against ischaemia/reperfusion injury through activation PI3K-Akt-NO signalling. The pathway connecting APJ to PI3K is still unknown. As other GPCR ligands act transactivation epidermal growth factor (EGFR) via matrix metalloproteinase (MMP) or Src kinase, we investigated whether EGFR involved in following three features apelin-induced cardioprotection: limitation infarct size, suppression...
Respirophasic variation of inferior vena cava (IVC) size is affected by large variability with spontaneous breathing. This study aims at characterizing the dependence IVC on controlled changes in intrathoracic pressure.Ten healthy subjects, supine position, performed isovolumetric respiratory efforts functional residual capacity, attaining positive (5, 10, and 15 mmHg) negative (-5, -10, -15 alveolar pressure levels. The constraint implies that equivalent are exhibited pressures during...
α-Linolenic acid (ALA)-enriched diet prevented isoproterenol (ISO)-induced fibrosis in the ventricular myocardium.
The stemness state is characterized by self-renewal and differentiation properties. However, stem cells are not able to preserve these characteristics in long-term culture because of the intrinsic fragility their phenotype easily undergoing senescence or neoplastic transformation. Furthermore, although isolated from same original tissue using similar protocols, adult can display dissimilar phenotypes important cell clone/species contamination. Finally, lack a clear standardization...
Low concentrations of a hydrophilic nitric oxide donor (NOD) are reported to reduce myocardial reperfusion injury only when combined with lipophilic antioxidant (AOX) form hybrid molecule (HYB). Here we tested whether liposoluble NOD requires be AOX protective. Isolated rat hearts underwent 30 minutes ischemia and 120 reperfusion. To induce postconditioning, 1 μM solutions the following compounds were given during first 20 reperfusion: weak (w-NOD) or strong NO-releasing potency (s-NOD); HYB...
Abstract Host immune responses at the site of Mycobacterium tuberculosis (Mtb) infection serve to contain pathogen, but also mediate pathogenesis (TB) and onward transmission infection. Interferon gamma (IFNγ) do not discriminate between protection pathogenicity, IL-17A/F responses, known drive pathology in diverse chronic inflammatory diseases, have been associated with TB animal models. At vivo recall Mtb modelled by tuberculin skin test, we show for first time that active humans is...