A5004629146- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Adolescent and Pediatric Healthcare
- Muscle and Compartmental Disorders
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Cardiovascular Function and Risk Factors
- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- Renal function and acid-base balance
- Healthcare cost, quality, practices
- Medical Malpractice and Liability Issues
- Clinical practice guidelines implementation
- Family Support in Illness
- Complement system in diseases
- Pharmacological Effects and Toxicity Studies
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Health and Disease Prevention
- Vascular Procedures and Complications
- Heart Failure Treatment and Management
- Climate Change and Health Impacts
- Hemoglobinopathies and Related Disorders
- Healthcare Quality and Management
- Restless Legs Syndrome Research
- Patient Safety and Medication Errors
Great Ormond Street Hospital for Children NHS Foundation Trust
2012-2024
Faculty (United Kingdom)
2024
Great Ormond Street Hospital
2011-2023
University College London
2012-2023
Goshen College
2019
Mitera Hospital
2019
Institute of Nephro Urology
2013
Arbor Research Collaborative for Health
2013
Royal Derby Hospital
2009
University of Nottingham
2009
Translocated endotoxin derived from intestinal bacteria has a wide range of adverse effects on cardiovascular (CV) structure and function, driving systemic inflammation, atherosclerosis oxidative stress. This study's aim was to investigate endotoxemia across the spectrum chronic kidney disease (CKD).Circulating measured in 249 patients comprising CKD stage 3 5 comparator cohort hypertensive without significant renal impairment. Patients underwent extended CV assessment, including pulse wave...
Globally, the number of patients undergoing maintenance dialysis is increasing, yet throughout world there significant variability in practice initiating dialysis. Factors such as availability resources, reasons for starting dialysis, timing initiation, patient education and preparedness, modality access, well varied "country-specific" factors significantly affect experiences outcomes. As burden end-stage kidney disease (ESKD) has increased globally, also been a growing recognition...
The general objective assigned to the EUropean DIALlysis (EUDIAL) Working Group by European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) was enhance quality of dialysis therapies in Europe broadest possible sense. Given increasing interest convective therapies, has started focusing on haemodiafiltration (HDF) therapies. Several reports suggest that those potentially improve outcomes for end-stage renal disease patients. is leader field, having introduced concept...
This guideline is written primarily for doctors and nurses working in dialysis units related areas of medicine the UK, an update a previous version 2009. It aims to provide guidance on how look after patients run units, provides standards which should general aim achieve. We would not advise interpret as rulebook, but perhaps answer question: "what does good quality haemodialysis like?"The split into sections: each begins with few statements are graded by strength (1 firm recommendation, 2...
In adults, hemodialysis (HD)-induced ischemia causes reversible myocardial dysfunction (myocardial stunning) that is progressive with raised attendant mortality. Children share an increased risk for death from a spectrum of uremia-related cardiovascular abnormalities but in the absence significant classical atheromatous coronary artery disease; therefore, we elected to assess children who were on HD occurrence stunning investigate relative importance characteristic uremic development...
To inform the development of a measure caregiver burden for carers children with chronic kidney disease, interviews were conducted 16 caregivers and 10 renal healthcare professionals. A pool 97 items generated from was reduced to 60 following review. piloting exercise provided evidence usability, readability relevance informed further adaptations resulting in 51-item Paediatric Renal Caregiver Burden Scale. Further assessment its psychometric properties, it is hoped that Scale will serve as...
There are three principle forms of vascular access available for the treatment children with end stage kidney disease (ESKD) by haemodialysis: tunnelled catheters placed in a central vein (central venous lines, CVLs), arteriovenous fistulas (AVF), and grafts (AVG) using prosthetic or biological material. Compared adult literature, there few studies to provide evidence based guidelines optimal type its management outcomes ESKD.The European Society Paediatric Nephrology Dialysis Working Group...
Significance Statement Although steroid-sensitive nephrotic syndrome (SSNS) is considered an autoimmune disease, its etiology poorly understood. Genome-wide association studies (GWAS) have provided important insights into other diseases, but so far, such reported associations only in the classical HLA region for SSNS. In a GWAS of large cohort European ancestry comprising 422 ethnically homogeneous pediatric patients and 5642 matched controls, authors found two loci outside associated with...
The provision of safe care is complex and difficult to achieve. Awareness what happens in real time one the ways develop a system within culture safety. At Great Ormond Street Hospital, we developed tested tool specifically designed for patients families report harm, with aim raising awareness opportunities staff continually improve provide care. Over 10-month period, processes harm. We used Model Improvement multiple Plan, Do, Study, Act cycles testing. measured changes using surveys as...
In adults, recurrent hemodialysis (HD)-induced cardiac injury results in ischemic myocardial dysfunction. Uremic children, like share the full complement of uremia-related cardiovascular abnormalities but without significant atheromatous coronary artery disease. The aim this study was, to assess impact HD on left ventricular (LV) function children. <b><i>Method:</i></b> We assessed all single-center chronic patients (n = 15, range 1-17 years) excluding those with...
Background Human health is inextricably linked to planetary health. The desire nurture and protect both concurrently requires the mitigation of healthcare-associated environmental harms global initiatives that support sustainable lifestyles. Health leadership important bring adequate attention action address challenges. professionals are central this endeavour, but will energy a few not be urgent challenge. Study We present an appraisal current UK professional standards, frameworks curricula...
The use of central venous catheters may be complicated by thrombosis and infection. We report a case needle‐phobic 5‐year‐old boy with factor IX deficiency, in whom portacath was inserted owing to poor compliance prophylactic treatment. Within week, he developed Staphylococcus aureus line infection that treated 2‐week course intravenous antibiotics. One month later presented nonspecific symptoms blood cultures again grew S. . An echocardiogram revealed large vegetation adherent the tricuspid...