A5068919447- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Heat shock proteins research
- Kidney Stones and Urolithiasis Treatments
- Muscle and Compartmental Disorders
- Renal Diseases and Glomerulopathies
- Social and Demographic Issues in Germany
- Chronic Kidney Disease and Diabetes
- Health and Medical Studies
- Central Venous Catheters and Hemodialysis
- Iron Metabolism and Disorders
- Pediatric Urology and Nephrology Studies
- Organ Transplantation Techniques and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Electrolyte and hormonal disorders
- Metabolism and Genetic Disorders
- Erythropoietin and Anemia Treatment
- Respiratory Support and Mechanisms
- Renal and related cancers
- Organ Donation and Transplantation
- Vitamin C and Antioxidants Research
- Clinical Nutrition and Gastroenterology
- Complement system in diseases
- Neonatal Respiratory Health Research
- Adolescent and Pediatric Healthcare
Medical University of Vienna
2015-2024
Universitätsklinik für Kinder und Jugendpsychiatrie
2002-2020
St Anna Children's Hospital
1989-2020
Mitera Hospital
2019
Great Ormond Street Hospital
2017
University College London
2017
Vienna General Hospital
2015
Zentrum für Kinderheilkunde
2002-2011
University of Defence
2010
Czech Academy of Sciences, Institute of Analytical Chemistry
2009
BackgroundIn chronic kidney disease (CKD), serum concentrations of fibroblast growth factor 23 (FGF23) increase progressively as glomerular filtration rate declines, while renal expression the FGF23 coreceptor Klotho decreases. Elevated circulating levels are strongly associated with mortality and left ventricular hypertrophy (LVH), which is a major cause cardiovascular death in CKD patients. The cardiac FGF23/FGF receptor (FGFR) system its role development LVH humans have not been addressed...
Whilst energy drinks improve performance and feelings of alertness, recent articles suggest that drink consumption combined with alcohol may reduce perception intoxication, or lead to increased drug use. This review discusses the available scientific evidence on effects mixing alcohol.A literature search was performed using keywords "energy Red Bull(®)" consulting Medline/Pubmed, PsycINFO, Embase.There is little antagonize behavioral alcohol, there no consistent alter perceived level...
There are three principle forms of vascular access available for the treatment children with end stage kidney disease (ESKD) by haemodialysis: tunnelled catheters placed in a central vein (central venous lines, CVLs), arteriovenous fistulas (AVF), and grafts (AVG) using prosthetic or biological material. Compared adult literature, there few studies to provide evidence based guidelines optimal type its management outcomes ESKD.The European Society Paediatric Nephrology Dialysis Working Group...
Cardiovascular disease (CVD) is the leading cause of increased mortality in patients with CKD and further aggravated by peritoneal dialysis (PD). Children are devoid preexisting CVD provide unique insight into specific uremia- PD-induced pathomechanisms CVD. We obtained specimens from children stage 5 at time PD catheter insertion (CKD5 group), established (PD age-matched nonuremic controls (n=6/group). microdissected omental arterioles tissue layers not directly exposed to fluid used...
In early clinical testing, acute addition of alanyl-glutamine (AlaGln) to glucose-based peritoneal dialysis (PD) fluids restored cellular stress responses and leukocyte function. This study was designed test the effect extended treatment with AlaGln-supplemented PD fluid on biomarkers health. a double-blinded, randomized crossover design, stable patients were treated AlaGln (8 mM) or placebo added for eight weeks. As primary outcome measures, dialysate cancer-antigen 125 (CA-125) appearance...
Abstract Background Chronic deterioration of kidney graft function is related to inadequate immunosuppression (IS). A novel tool assess the individual net state IS in transplanted patients might be monitoring Torque teno virus (TTV) viral load. TTV a non-pathogen detectable almost all individuals. level peripheral blood has been linked immune-competence its host and should thus reflect after solid organ transplantation. Methods plasma load was quantified monthly by RT-PCR for period 1 year...
During peritoneal dialysis (PD), epithelial-mesenchymal transition (EMT) is likely involved in aberrant healing and progressive fibrosis. Recently, EMT of the kidney was actively reversed into opposite direction, mesenchymal-epithelial (MET), by treatment with bone morphogenic protein-7 (BMP-7). In this study, potential for ex vivo interconversion transdifferentiation processes investigated mesothelial cells.In assessed cell cultures randomly grown from effluents seven patients on chronic...
Management of children with congenital nephrotic syndrome (CNS) is challenging. Bilateral nephrectomies followed by dialysis and transplantation are practiced in most centres, but conservative treatment may also be effective.We conducted a 6-year review across members the European Society for Paediatric Nephrology Dialysis Working Group to compare management strategies their outcomes CNS.Eighty (50% male) 17 tertiary nephrology units Europe were included (mutations NPHS1, n = 55; NPHS2, 1;...
NOS1AP variants impair actin remodeling in podocytes and cause glomerular disease humans, kidney organoids, mice.
Lithium added to peritoneal dialysis fluid protects mesothelial cells and attenuates fibrosis angiogenesis by reducing αB-crystallin.
Background.Exposure of mesothelial cells to peritoneal dialysis fluids (PDF) results in cytoprotective cellular stress responses (CSR) that counteract PDF-induced damage. In this study, we tested the hypothesis CSR may be inadequate relevant models (PD) due insufficient levels glutamine, resulting increased vulnerability against PDF cytotoxicity. We particularly investigated role alanyl–glutamine (Ala-Gln) dipeptide on proteome.
Background Peritonitis and ultrafiltration failure remain serious complications of chronic peritoneal dialysis (PD). Dysfunctional cellular stress responses aggravate injury associated with PD fluid exposure, potentially due to glutamine depletion. In this randomized cross-over phase I/II trial we investigated cytoprotective effects alanyl-glutamine (AlaGln) addition glucose-based PDF. Methods a prospective design, 20 stable outpatients underwent paired equilibration tests 4 weeks apart,...
Long-term allograft and patient survival after kidney transplantation (KTX) depends on the balance between over- under-immunosuppression (IS). High levels of IS predispose to opportunistic infections. Plasma load Torque Teno Virus (TTV), a non-pathogenic highly prevalent Annellovirus, is associated with its hosts immune status, especially solid organ transplantation.
The small heat-shock proteins appear to have a regulatory role in actin dynamics. Since cytoskeletal disruption is integral ischemic renal injury, we evaluated expression and intracellular distribution of protein 25 (HSP-25) rat cortex after 45 min ischemia. HSP-25 was constitutively expressed induced by ischemia with peak levels reached 6 h reflow. Ischemia caused shift from the detergent-soluble into insoluble fraction. By 2 reflow, majority had redistributed soluble predominantly...
In addition to low pH and high osmolarity, glucose degradation products (GDPs) are considered play a major role in the bioincompatibility of peritoneal dialysis fluids (PDFs). The formation GDPs can be reduced by separating component solution (kept at very pH) from lactate alkaline during sterilization storage. This development has been achieved use dual-chambered bag. Immediately before infusion, seam between two chambers is opened, contents mixed. result fluid with more physiologic range...