A5056502498- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Iron Metabolism and Disorders
- Muscle and Compartmental Disorders
- Folate and B Vitamins Research
- Erythropoietin and Anemia Treatment
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Health Systems, Economic Evaluations, Quality of Life
- Metabolism and Genetic Disorders
- Blood Pressure and Hypertension Studies
- Esophageal and GI Pathology
- Acute Kidney Injury Research
- Heart Failure Treatment and Management
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Health and Disease Prevention
- Adrenal Hormones and Disorders
- Hemoglobinopathies and Related Disorders
- Hemodynamic Monitoring and Therapy
- Clinical Nutrition and Gastroenterology
- Potassium and Related Disorders
- Healthcare cost, quality, practices
- Infective Endocarditis Diagnosis and Management
- Kidney Stones and Urolithiasis Treatments
- Metabolomics and Mass Spectrometry Studies
Medical University of Vienna
2013-2023
University of Vienna
1998-2014
RHI Magnesita (Austria)
2005
Royal Stoke University Hospital
2005
Institute for Pharmaeconomic Research
2005
Friedrich-Alexander-Universität Erlangen-Nürnberg
2004
University of Tübingen
2004
Mater Misericordiae University Hospital
2004
Molecular Medicine Ireland
2004
University College Dublin
2004
Calciphylaxis is a life-threatening complication in patients with end-stage renal disease (ESRD). No established therapy exists so far. The aim of the present study was to determine therapeutic response multi-interventional treatment regimen consistent use sodium thiosulphate (STS) an Austrian cohort calciphylaxis patients. We retrospectively collected demographic, clinical and laboratory data on 27 treated STS at seven dialysis centres between June 2004 November 2010. Twenty-seven (68 ± 12...
Hypokalemia, including normal range values <4 mEq/l, has been associated with increased peritonitis and mortality in patients peritoneal dialysis. This study sought to describe international variation hypokalemia, potential modifiable hypokalemia risk factors, the covariate-adjusted relationship of mortality.Baseline serum potassium was determined 7421 from 7 countries Peritoneal Dialysis Outcomes Practice Patterns Study (2014-2017). Association baseline patient treatment factors subsequent...
Peritoneal dialysis (PD) solutions with reduced sodium content may have advantages for hypertensive patients; however, they lower osmolarity and solvent drag, so the achieved Kt/Vurea be lower. Furthermore, increased transperitoneal membrane gradient can influence balance consequences blood pressure (BP) control.Prospective, randomized, double-blind clinical trial to prove noninferiority of total weekly low-sodium versus standard-sodium PD solution, confidence limit above clinically accepted...
In early clinical testing, acute addition of alanyl-glutamine (AlaGln) to glucose-based peritoneal dialysis (PD) fluids restored cellular stress responses and leukocyte function. This study was designed test the effect extended treatment with AlaGln-supplemented PD fluid on biomarkers health. a double-blinded, randomized crossover design, stable patients were treated AlaGln (8 mM) or placebo added for eight weeks. As primary outcome measures, dialysate cancer-antigen 125 (CA-125) appearance...
Background. Residual renal function is an independent predictor of survival in peritoneal dialysis patients. Systemic administration radio contrast media (CM) may increase the risk acute failure patients with impaired not on dialysis. There are few data influence CM
Catheter-associated infections markedly contribute to treatment failure in peritoneal dialysis (PD) patients. There is much controversy surrounding prophylactic strategies prevent these infections.In this nationwide multicenter study we analyzed catheter-associated as performed Austrian PD centers 2006. A questionnaire was sent all 23 Austria.Ten different catheter models were used the 332 patients being treated centers. Systemic antibiotics prior placement given by 17 of (glycopeptides, n =...
Lithium added to peritoneal dialysis fluid protects mesothelial cells and attenuates fibrosis angiogenesis by reducing αB-crystallin.
Catheter-related infection is one of the most important causes technical dropout in peritoneal dialysis patients. Both type cultured organism and extent inflammation are well known prognostic factors for outcome these infections. From December 1994 to November 1996, 96 catheter-related infections without simultaneous peritonitis occurred 49 86 patients treated this study. During observation period, only single-cuff catheters were used. Staphylococcus aureus was common (51%). Involvement...
The importance of Staphylococcus aureus as etiological agent for catheter-related infections and peritonitis in peritoneal dialysis patients is well established. To evaluate groups at risk developing infections, nasal exit-site cultures were performed 76 monthly over a period 3 yr. catheter infection was significantly higher diabetic (group 1) immunosuppressed 2) compared with nondiabetic nonimmunosuppressed 3) patients. In patients, aureus-positive more frequent than positive taken from the...
Peritonitis is a major complication of peritoneal dialysis (PD) being associated with hospitalization, catheter loss, technique failure, and increased mortality. Data on incidence rates risk factors for peritonitis episodes vary between centers. In seven Austrian PD units clinical laboratory data each episode were collected from all patients (n = 726) who performed January 2000 December 2009. The rate was 0.32 episodes/patient-year. multivariate analysis the decreased by 57% in treated oral...
Background Peritonitis and ultrafiltration failure remain serious complications of chronic peritoneal dialysis (PD). Dysfunctional cellular stress responses aggravate injury associated with PD fluid exposure, potentially due to glutamine depletion. In this randomized cross-over phase I/II trial we investigated cytoprotective effects alanyl-glutamine (AlaGln) addition glucose-based PDF. Methods a prospective design, 20 stable outpatients underwent paired equilibration tests 4 weeks apart,...
Background/Objectives: Peritoneal dialysis (PD) is a renal replacement therapy for patients with kidney failure. Managing PD often involves addressing complex interplay of comorbidities and complications, necessitating the use multiple medications. This study aimed to systematically characterize commonly co-prescribed drugs in identify novel drug combinations that may target dysregulated molecular mechanisms associated PD’s pathophysiology. Methods: We analyzed clinical records from 702...
The effect of thiamine (vitamin B(1)) or riboflavin B(2)) availability on fasting total homocysteine (tHcy) plasma levels in end-stage renal disease patients is unknown. A cross-sectional study was performed a population non-vitamin supplemented maintained continuous ambulatory peritoneal dialysis. Red blood cell (alpha-ETK) and (alpha-EGR), along with other predictors tHcy levels, considered the analysis. There linear association alpha-EGR concentrations (P = 0.009), which not observed for...
The ability of cells to respond and survive stressful conditions is determined, in part, by the attachment O-linked N-acetylglucosamine (O-GlcNAc) proteins (O-GlcNAcylation), a post-translational modification dependent on glucose glutamine. This study investigates role dynamic O-GlcNAcylation mesothelial cell survival during exposure glucose-based peritoneal dialysis fluid (PDF). Immortalized human primary cells, cultured from omentum or clinical effluent PD patients, were assessed for under...
Clearance of invading pathogens is essential to preventing overwhelming inflammation and sepsis that are symptomatic bacterial peritonitis. Macrophages participate in this innate immune response by engulfing digesting pathogens, a process called phagocytosis. Oxidized phospholipids (OxPL) danger-associated molecular patterns (DAMPs) generated infection can prevent the phagocytic clearance bacteria. We investigated mechanism underlying OxPL action macrophages. Exposure induced alterations...
Readily available peritoneal dialysis (PD) effluents from PD patients in the course of renal replacement therapy are a potentially rich source for molecular markers predicting clinical outcome, monitoring and therapeutic interventions. The complex phenotype might be reflected effluent metabolome. Metabolomic analysis allow quantitative detection assessment candidate biomarkers prognostication monitoring. We therefore subjected equilibration test 20 stable patients, obtained randomized...