A5002475006- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Heat shock proteins research
- Acute Kidney Injury Research
- Nitric Oxide and Endothelin Effects
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Polyomavirus and related diseases
- Renin-Angiotensin System Studies
- Infant Nutrition and Health
- Erythropoietin and Anemia Treatment
- Celiac Disease Research and Management
- Ion Transport and Channel Regulation
- Blood groups and transfusion
- Microscopic Colitis
- Neonatal Respiratory Health Research
- Platelet Disorders and Treatments
- Dialysis and Renal Disease Management
- Erythrocyte Function and Pathophysiology
- Endoplasmic Reticulum Stress and Disease
- Urinary and Genital Oncology Studies
- Organ Transplantation Techniques and Outcomes
- Aldose Reductase and Taurine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Medical University of Vienna
2013-2024
St Anna Children's Hospital
2017
In-Q-Tel
2016
Hungarian Academy of Sciences
2004-2014
Semmelweis University
2005-2013
Klinikum rechts der Isar
2009-2012
Technical University of Munich
2010-2011
Maastricht University
2010
Summary Inflammatory bowel disease (IBD) may result from exaggerated stimulation of the mucosal immune system by luminal bacterial flora. Bacterial products are recognized pattern recognition receptors such as Toll-like (TLRs), which key regulators innate system. Therefore, expression TLR2, TLR3 and TLR4 in colonic biopsy samples taken children with active IBD were studied compared to controls. Colonic collected macroscopically inflamed non-inflamed regions mucosa 12 freshly diagnosed...
BK polyomavirus-associated nephropathy (BKPyVAN) constitutes a serious cause of kidney allograft failure, but large-scale data in pediatric renal transplant recipients and comprehensive analysis specific risk factors are lacking.We analyzed the 313 patients Cooperative European Pediatric Renal Transplant Initiative Registry, with an observation period 3.3 years (range, 1-5). The net state immunosuppressive therapy was assessed by modified Vasudev score.Presumptive BKPyVAN (defined as...
The dysregulation of adaptive immunity is extensively investigated in celiac disease (CD). Recent data also suggest, however, the implication innate CD. Toll-like receptors (TLRs) play a central role initiation or maintenance immune responses. aim this study was to characterise expression TLR2, TLR3, and TLR4 duodenal biopsy samples taken from children with CD controls.Duodenal specimens were collected 16 untreated CD, 9 treated 10 controls. mRNA determined by semiquantitative reverse...
<h3>Objective</h3> Biomarkers play a pivotal role in heart failure (HF) management. Reference values and insights from studies adults cannot be extrapolated to the paediatric population due important differences pathophysiology compensatory reserve. We assessed diagnostic utility of four novel biomarkers HF. <h3>Methods</h3> Midregional (MR) pro-atrial natriuretic peptide (proANP), soluble ST2 (sST2), growth differentiation factor-15 (GDF-15), MR-pro-adrenomedullin (proADM) N-terminal pro-B...
Abstract Background Chronic deterioration of kidney graft function is related to inadequate immunosuppression (IS). A novel tool assess the individual net state IS in transplanted patients might be monitoring Torque teno virus (TTV) viral load. TTV a non-pathogen detectable almost all individuals. level peripheral blood has been linked immune-competence its host and should thus reflect after solid organ transplantation. Methods plasma load was quantified monthly by RT-PCR for period 1 year...
Previously, we demonstrated gender differences in Na-K-ATPase (NKA) expression and function after renal ischemia-reperfusion (I/R) injury (Sex the alterations of Na(+), K(+)-ATPase following rat kidney. J Physiol 555: 471-480, 2004). Postischemic membrane destruction causes inhibition NKA, whereas heat shock protein (HSP) 72 helps to preserve it. We tested sex postischemic HSP72 colocalization with NKA. The left pedicle uninephrectomized female (F) male (M) Wistar rats was clamped for 55 min...
Lithium added to peritoneal dialysis fluid protects mesothelial cells and attenuates fibrosis angiogenesis by reducing αB-crystallin.
Objectives: Inadequate response of the innate immune system to bacterial antigens present in intestinal flora may play a role development necrotizing enterocolitis (NEC). Pattern recognition receptors such as CD14, toll-like receptor (TLR) 4, and caspase-recruitment domain (CARD) 15 bind lipopolysaccharide peptidoglycan, their activation leads production inflammatory cytokines. Our aim was evaluate whether single nucleotide polymorphisms (SNPs) TLR4, CARD15 are associated with risk NEC very...
Objectives It is known that transition, as a shift of care, marks vulnerable phase in the adolescents’ lives with an increased risk for non-adherence and allograft failure. Still, transition process adolescents young adults living kidney transplant Germany not well defined. The present research aims to assess transition-relevant structures this group people. Special attention paid timing process. Setting In observational study, we visited 21 departments paediatric nephrology Germany....
Long-term allograft and patient survival after kidney transplantation (KTX) depends on the balance between over- under-immunosuppression (IS). High levels of IS predispose to opportunistic infections. Plasma load Torque Teno Virus (TTV), a non-pathogenic highly prevalent Annellovirus, is associated with its hosts immune status, especially solid organ transplantation.
<i>Background:</i> Galectin-9 (Gal-9) is a member of the growing family β-galactoside-binding lectins. Gal-9 an eosinophil chemoattractant and inducer Th1 cell apoptosis. These effects suggest its potential role in pathogenesis asthma. Our aim was to study expression ovalbumin (OVA)-induced mouse model allergic <i>Methods:</i> To investigate significance inflammation airway hyperresponsiveness (AHR), group BALB/c mice sensitized challenged with OVA...
Background Factor H-related protein 5 (FHR-5) is a member of the complement H family. Due to homology H, main regulator alternative pathway, it may also be implicated in pathomechanism kidney diseases where and pathway dysregulation play role. Here, we report first observational study on CFHR5 variations along with serum FHR-5 levels immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) C3 glomerulopathy (C3G) patients together clinical, genetic, complement, follow-up...
The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine threonine protein activated through the phosphatidylinositol 3-kinase (PI3-kinase) pathway counteracting apoptosis. Protein expression activation of SGK1 are increased in various models cell stress. present study explored role renal hypoxia/ischemia induced HEK 293 cells were exposed vitro to hypoxia/reoxygenation (H/R), which transcript levels, abundance phosphorylation. H/R injury further enhanced percentage apoptotic...
Smoking is the leading risk factor of chronic obstructive pulmonary disease (COPD) and lung cancer. Corticosteroids are abundantly used in these patients; however, interaction smoking steroid treatment not fully understood. Heat shock proteins (Hsps) play a central role maintenance cell integrity, apoptosis cellular action. To better understand cigarette smoke-steroid interaction, we examined effect smoke extract (CSE) and/or dexamethasone (DEX) on changes intracellular heat protein-72...
Abstract Background Acquired or genetic abnormalities of the complement alternative pathway are primary cause C3glomerulopathy(C3G) but may occur in immune-complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) as well. Less is known about presence and role C4nephritic factor(C4NeF) which stabilize classical C3-convertase. Our aim was to examine C4NeF its connection with clinical features other pathogenic factors. Results One hunfe IC-MPGN/C3G patients were enrolled study....
Angiotensin II (ANGII) plays a central role in the enhanced sodium reabsorption early type 1 diabetes man and streptozotocin‐induced (STZ) diabetic rats. This study investigates effect of untreated STZ‐diabetes leading to nephropathy combination with ANGII treatment, on abundance localization renal Na + ,K ‐ATPase (NKA), major contributor handling. After 7 weeks ( i.v. 65 mg kg −1 ) subgroup control (C) (D7) Wistar rats were treated s.c. minipump 33 μg h for 24 h; CA D7A). We measured...