A5069686977- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Atherosclerosis and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Immune Cell Function and Interaction
- Cardiac Fibrosis and Remodeling
- Protease and Inhibitor Mechanisms
- Cytokine Signaling Pathways and Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Cell Adhesion Molecules Research
- Heart Failure Treatment and Management
- Lipoproteins and Cardiovascular Health
- Acute Ischemic Stroke Management
- Angiogenesis and VEGF in Cancer
- Cardiovascular Disease and Adiposity
- GDF15 and Related Biomarkers
- Peptidase Inhibition and Analysis
- Cardiovascular Function and Risk Factors
- Signaling Pathways in Disease
- Extracellular vesicles in disease
- Cerebrovascular and Carotid Artery Diseases
- Acute Kidney Injury Research
- Aortic Disease and Treatment Approaches
- Cardiac electrophysiology and arrhythmias
- Telomeres, Telomerase, and Senescence
Medical University of Vienna
2016-2025
Klinik Hietzing
2024-2025
Vorarlberg Institute for Vascular Investigation and Treatment
2018
Peter the Great St. Petersburg Polytechnic University
2018
Wilhelminen Hospital
2004-2017
Ludwig Boltzmann Cluster for Cardiovascular Research
2006-2017
Universität für Weiterbildung Krems
2017
Justus-Liebig-Universität Gießen
2014
Leiden University Medical Center
2012
Babraham Institute
2012
Interleukin-33 (IL-33) is a recently described member of the IL-1 family cytokines, which was identified as ligand for ST2 receptor. Components IL-33/ST2 system were shown to be expressed in normal and pressure overloaded human myocardium, soluble (sST2) has emerged prognostic biomarker myocardial infarction heart failure. However, expression regulation IL-33 adult cardiac myocytes fibroblasts not tested before. In this study we found that primary (HACF) (HACM) constitutively express nuclear...
Interleukin (IL)-33 is the most recently described member of IL-1 family cytokines and it a ligand ST2 receptor. While effects IL-33 on immune system have been extensively studied, properties this cytokine in cardiovascular are much less investigated. Methods/Results- We show here that promoted adhesion human leukocytes to monolayers endothelial cells robustly increased vascular cell molecule-1, intercellular selectin, monocyte chemoattractant protein-1 protein production mRNA expression...
Using proteomics, we aimed to reveal molecular types of human atherosclerotic lesions and study their associations with histology, imaging, cardiovascular outcomes.
Polyunsaturated fatty acids are precursors of multiple pro- and anti-inflammatory molecules generated by enzymatic stereospecific positionally specific insertion oxygen, which is a prerequisite for recognition these mediators cellular receptors. However, nonenzymatically oxidized free esterified polyunsaturated also demonstrate activities relevant to inflammation. In particular, phospholipids containing acid residues (oxidized phospholipids; OxPLs) were shown induce proinflammatory changes...
Objectives ST2 is a receptor for interleukin (IL)-33. We investigated an association of soluble (sST2) and IL-33 serum levels with different clinical stages coronary artery disease. assessed the predictive value sST2 in patients stable angina, non-ST elevation myocardial infarction (NSTEMI) ST (STEMI). Methods included 373 whom 178 had 97 NSTEMI, 98 STEMI. Patients were followed mean 43 months. The control group consisted 65 individuals without significant stenosis on angiography. Serum...
Abstract Tissue factor (TF) is the primary trigger of coagulation. Elevated levels TF are found in atherosclerotic plaques and leads to thrombus formation when released upon plaque rupture. Interleukin (IL)-33 was previously shown induce angiogenesis inflammatory activation endothelial cells (ECs). Here, we investigated impact IL-33 on human ECs, as a possible new link between inflammation induced mRNA protein umbilical vein ECs coronary artery ECs. IL-33-induced expression ST2-...
The recent concept of secretome-based tissue regeneration has profoundly altered the field regenerative medicine and offers promising novel therapeutic options. In contrast to medicinal products with a single active substance, cell-derived secretomes comprise pleiotropic bioactive ingredients, representing major obstacle for reproducible drug product efficacy warranting patient safety. Good manufacturing practice (GMP)-compliant production guarantees high batch-to-batch consistency...
It is believed that adipose tissue acts as an endocrine organ by producing inflammatory mediators and thereby contributes to the increased cardiovascular risk seen in obesity. A link between mass angiogenesis has been suggested. Vascular endothelial growth factor (VEGF) seems be implicated this process. Members of glycoprotein (gp)130 ligand family regulate VEGF expression other cells.We used explants well primary cultures preadipocytes adipocytes from human subcutaneous visceral investigate...
<h3>Objective</h3> Biomarkers play a pivotal role in heart failure (HF) management. Reference values and insights from studies adults cannot be extrapolated to the paediatric population due important differences pathophysiology compensatory reserve. We assessed diagnostic utility of four novel biomarkers HF. <h3>Methods</h3> Midregional (MR) pro-atrial natriuretic peptide (proANP), soluble ST2 (sST2), growth differentiation factor-15 (GDF-15), MR-pro-adrenomedullin (proADM) N-terminal pro-B...
Background— Adipose tissue is a prominent source of plasminogen activator inhibitor-1 (PAI-1), the primary physiological inhibitor activation. Increased PAI-1 expression acts as cardiovascular risk factor, and plasma levels strongly correlate with body mass index (BMI). Elevated serum interleukin-6 (IL-6), an inflammatory cytokine member glycoprotein 130 (gp130) ligand family, are found in obese patients might indicate low-grade systemic inflammation. Another gp130 ligand, oncostatin M...
Recently, 3 clinical trials revealed encouraging results in recanalization and outcome acute stroke patients when 2-MHz transcranial Doppler monitoring was applied. This study investigated whether a 1.8-MHz commercial diagnostic ultrasound device has the potential to facilitate thrombolysis using an vitro model.Duplex-Doppler, continuous wave-Doppler, pulsed wave (PW)-Doppler were compared on their impact recombinant tissue plasminogen activator (rtPA)-mediated thrombolysis. Blood clots...
Neutrophil gelatinase-associated lipocalin (NGAL), an acute phase protein released by neutrophils, has been described as biomarker of inflammatory states. Type 2 diabetes mellitus (T2DM) is characterized increased inflammation and elevated risk for embolization carotid artery stenosis (CAS). We aimed to explore the role NGAL systemically in plaques diabetics undergoing endarterectomy. Moreover, potential anti-inflammatory effect metformin on was addressed diabetics. Serum matrix...
Neutrophil gelatinase associated lipocalin (NGAL) is expressed in atherosclerotic lesions and was recently implicated the pathogenesis of cardiovascular pathologies. Statins are known to exert stabilizing effects on plaque. The aims our study were (1) investigate association serum NGAL metalloproteinase (MMP)-9/NGAL complex with vulnerability plaque, (2) reveal statin treatment circulating MMP-9/NGAL levels patients carotid artery stenosis.We examined blood samples from 136 stenosis by...
Monocytes and monocyte-derived microvesicles (MVs) are the main source of circulating tissue factor (TF). Increased monocyte TF expression increased levels procoagulant MVs contribute to formation a prothrombotic state in patients with cardiovascular disease. Interleukin (IL)-33 is pro-inflammatory cytokine involved atherosclerosis other inflammatory diseases, but its role regulating thrombosis still unclear. The aim present study was investigate effects IL-33 on properties human monocytes...
The study aim was to determine the predictive value of interleukin (IL)-33, a recently described member IL-1 family cytokines, for development in-stent restenosis (ISR). IL-33 serum levels were measured in 387 consecutive patients undergoing percutaneous coronary intervention (PCI) whom 193 had stable angina, 93 non-ST elevation myocardial infarction (NSTEMI), and 101 ST-elevation MI (STEMI), respectively. Blood taken directly before 24h after stent implantation. presence ISR initially...
Obesity is considered to be a major comorbidity. Obese patients suffer from an increased proinflammatory state associated with premature aging phenotype including secretion of senescence-associated secretory proteins (SASP) and reduced telomere length. Micro-ribonucleic acids (miRNAs) are non-coding RNA molecules that could modify the post-transcriptional process. Several studies have reported associations between miRNAs metabolic unhealthy conditions.To determine if bariatric surgery...