A5045177184- IL-33, ST2, and ILC Pathways
- COVID-19 Clinical Research Studies
- Eosinophilic Esophagitis
- Health and Medical Studies
- Telomeres, Telomerase, and Senescence
- Electronic Health Records Systems
- Genetics, Aging, and Longevity in Model Organisms
- Medical and Health Sciences Research
- Medical Practices and Rehabilitation
- Garlic and Onion Studies
- Health Systems, Economic Evaluations, Quality of Life
- Mobile Health and mHealth Applications
- COVID-19 and Mental Health
- Sociology and Education Studies
- DNA Repair Mechanisms
- COVID-19 Impact on Reproduction
- Global Maternal and Child Health
- Immune Cell Function and Interaction
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- Cardiovascular Disease and Adiposity
- Vitamin D Research Studies
- Maternal Mental Health During Pregnancy and Postpartum
Public Health Institute
2021-2024
Gesundheit Österreich
2021-2024
University of Lisbon
2019
Medical University of Vienna
2011-2018
Ludwig Boltzmann Cluster for Cardiovascular Research
2011
Medical University of Graz
2011
University of Lübeck
1990
Abstract Telomerase negative immortal cancer cells elongate telomeres through the Alternative Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is required to maintain ALT, it might also lead cell death when excessive. Here, we show that ATPase/translocase activity FANCM keeps in check specifically ALT cells. When depleted cells, become dysfunctional, and stop proliferating die. depletion increases ALT-associated marks de novo synthesis DNA. Depletion BLM...
Interleukin-33 (IL-33) is a recently described member of the IL-1 family cytokines, which was identified as ligand for ST2 receptor. Components IL-33/ST2 system were shown to be expressed in normal and pressure overloaded human myocardium, soluble (sST2) has emerged prognostic biomarker myocardial infarction heart failure. However, expression regulation IL-33 adult cardiac myocytes fibroblasts not tested before. In this study we found that primary (HACF) (HACM) constitutively express nuclear...
Interleukin (IL)-33 is the most recently described member of IL-1 family cytokines and it a ligand ST2 receptor. While effects IL-33 on immune system have been extensively studied, properties this cytokine in cardiovascular are much less investigated. Methods/Results- We show here that promoted adhesion human leukocytes to monolayers endothelial cells robustly increased vascular cell molecule-1, intercellular selectin, monocyte chemoattractant protein-1 protein production mRNA expression...
During the first epidemic wave, COVID-19 surveillance focused on quantifying magnitude and escalation of a growing global health crisis. The scientific community assessed risk through basic indicators, such as number cases or rates new deaths, later began using other direct impact indicators to conduct more detailed analyses. We aimed at synthesizing community's contribution assessing pandemic population reported in research papers.
Abstract Interleukin ( IL )‐33 is a member of the ‐1 family and able to act cardioprotective. The aim this study was investigate regulation ‐33 by 3‐hydroxy‐3‐methylglutaryl‐coenzyme‐A HMG ‐CoA) reductase inhibitors (statins) bisphosphonates BP s) in human cardiac tissue. lipophilic fluvastatin, simvastatin, atorvastatin, lovastatin as well nitrogenous s alendronate ibandronate, but not hydrophilic pravastatin increased mRNA intracellular protein levels both adult myocytes HACM ) fibroblasts...
Abstract Austria has long lacked comprehensive data on the health and well-being of sexual gender minorities (SGMs). The 2022 LGBTIQ+ Health Report addresses this gap by presenting a overview status SGMs in Austria. To contextualize SGM issues, review literature, surveys, action plans across Europe was conducted initial project phase. Then questionnaire developed collaboration with an expert group for quantitative collection. A total 1,047 individuals participated survey; analyses were...
Timely and high-quality population-level health information is needed to support evidence-informed decision-making, for planning evaluation of prevention, care cure activities as well research generate new knowledge. FAIR (Findable, Accessible, Interoperable Reusable) principles are one the key elements supporting making it more cost-effective through reuse already existing data. Currently, data in many countries dispersed difficult find access.
Methods: Twenty-eight healthy male Wistar rats were divided into two groups, receiving vehicle (Control; n¼13) or ivabradine (IVA; 10 mg/kg/day; n¼15) in the drinking water for three consecutive weeks.All implanted with radiotelemetry ECG devices and 72-h continuous monitoring was performed freely moving rats.Heart rate variability indexes time frequency domains evaluated.Results: As expected, significantly decreased resting heart (351629 bpm Control vs. 294631 IVA; p<0.0001).Chronic...
Introduction The aim of this EUnetHTA (European Network for Health Technology Assessment) Rolling Collaborative Review on high dose vitamin D the treatment COVID-19 was to inform health policy at an early stage in life cycle therapies and monitor ongoing studies format a Living Document. Methods systematic literature search conducted Medline, Pubmed, medRxiv, bioRxiv, arXivso, Cochrane Study Register, ClinicalTrials.gov, ISRCTN Registry, EU Clinical Trials Register. first done January 2021,...