A5045409568- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Atrial Fibrillation Management and Outcomes
- Protease and Inhibitor Mechanisms
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Lipoproteins and Cardiovascular Health
- Cardiac Fibrosis and Remodeling
- Complement system in diseases
- Blood Coagulation and Thrombosis Mechanisms
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac pacing and defibrillation studies
- Long-Term Effects of COVID-19
- Infrared Thermography in Medicine
- Ultrasound and Hyperthermia Applications
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Transplantation: Methods and Outcomes
- Immune cells in cancer
- Mechanical Circulatory Support Devices
- Cytokine Signaling Pathways and Interactions
Medical University of Vienna
2015-2024
Ludwig Boltzmann Cluster for Cardiovascular Research
2004-2020
Justus-Liebig-Universität Gießen
2014
Medical University of Graz
2011
Wilhelminen Hospital
2004-2008
Boise VA Medical Center
2008
Thrombosis Research Institute
2007
Institut Cochin
2007
TU Wien
2004
University of Vienna
2004
Interleukin (IL)-33 is the most recently described member of IL-1 family cytokines and it a ligand ST2 receptor. While effects IL-33 on immune system have been extensively studied, properties this cytokine in cardiovascular are much less investigated. Methods/Results- We show here that promoted adhesion human leukocytes to monolayers endothelial cells robustly increased vascular cell molecule-1, intercellular selectin, monocyte chemoattractant protein-1 protein production mRNA expression...
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by obstruction of major arteries with organized thrombi. Clinical risk factors for due to left heart disease including metabolic syndrome, left-sided valvular disease, and ischemic are common in CTEPH patients. The authors sought investigate prevalence prognostic implications elevated ventricular filling pressures (LVFP) CTEPH. A total 593 consecutive patients undergoing a first diagnostic right catheterization were...
Complement activation occurs in atherosclerotic lesions, and particularly complement component C5a exerts potent chemotactic proinflammatory effects. However, it is yet unknown, whether plasma levels of may predict cardiovascular risk. The aim this study was to examine the risk patients with advanced atherosclerosis.We studied 173 symptomatic peripheral artery disease (median age 72, 82 male). Cardiovascular profile, factor C5a, other non-specific inflammatory parameters [high sensitivity...
Tricuspid regurgitation secondary to heart failure (HF) is common with considerable impact on survival and hospitalization rates. Currently, insights into epidemiology, impact, treatment of tricuspid (sTR) across the entire HF spectrum are lacking, yet necessary for healthcare decision-making.
It is believed that adipose tissue acts as an endocrine organ by producing inflammatory mediators and thereby contributes to the increased cardiovascular risk seen in obesity. A link between mass angiogenesis has been suggested. Vascular endothelial growth factor (VEGF) seems be implicated this process. Members of glycoprotein (gp)130 ligand family regulate VEGF expression other cells.We used explants well primary cultures preadipocytes adipocytes from human subcutaneous visceral investigate...
Abstract Background Guideline-directed medical therapy (GDMT) is the recommended initial treatment for secondary mitral regurgitation (SMR), however, supported by only little comprehensive evidence. This study, therefore, sought to assess effect of GDMT titration on SMR and identify specific substance combinations able reduce severity. Methods results We included 261 patients who completed two visits with an echocardiographic exam available within 1 month at each visit. After comprehensively...
Post-COVID fatigue significantly limits recovery and return-to-work in COVID-19 survivors. We aimed to assess the effects of physical exercising on post-COVID-19-symptoms, physical/mental capacities workability within a workplace-health-promotion project health-care personnel.Thirty-two HCWs were enrolled two groups based Post-COVID-Functional Scale (PCFS) scores: (1) severe (SSG, n = 11) (2) mild (MSG, 21) symptoms. The participants underwent an eight week exercise intervention program...
Background— Adipose tissue is a prominent source of plasminogen activator inhibitor-1 (PAI-1), the primary physiological inhibitor activation. Increased PAI-1 expression acts as cardiovascular risk factor, and plasma levels strongly correlate with body mass index (BMI). Elevated serum interleukin-6 (IL-6), an inflammatory cytokine member glycoprotein 130 (gp130) ligand family, are found in obese patients might indicate low-grade systemic inflammation. Another gp130 ligand, oncostatin M...
Recently, 3 clinical trials revealed encouraging results in recanalization and outcome acute stroke patients when 2-MHz transcranial Doppler monitoring was applied. This study investigated whether a 1.8-MHz commercial diagnostic ultrasound device has the potential to facilitate thrombolysis using an vitro model.Duplex-Doppler, continuous wave-Doppler, pulsed wave (PW)-Doppler were compared on their impact recombinant tissue plasminogen activator (rtPA)-mediated thrombolysis. Blood clots...
Atherosclerosis is considered to be an inflammatory disease in which monocytes and monocyte-derived macrophages play a key role. Circulating can divided into three distinct subtypes, namely classical (CM; CD14++CD16-), intermediate (IM; CD14++CD16+) non-classical (NCM; CD14+CD16++). Low density lipoprotein particles are heterogeneous size density, with small, dense LDL (sdLDL) crucially implicated atherogenesis. The aim of this study was examine whether monocyte subsets associated sdLDL...
•Lipoprotein(a) serves as an independent risk factor in atherosclerotic disease.•Monocyte subsets exhibit distinct inflammatory and atherogenic properties.•Patients with elevated levels of Lp(a) show a shift towards intermediate monocytes.•This association was clinical properties markers.•Those patients also exhibited higher OxPL/apoB concentrations. BackgroundLipoprotein(a) (Lp(a)) is proatherogenic plasma lipoprotein currently established for the development disease predictor acute...
Novel ribonucleic acid interference (RNAi) therapeutics such as patisiran and inotersen have been shown to benefit neurologic disease course quality of life in patients with hereditary transthyretin amyloidosis (ATTRv). We aimed determine the impact RNAi on myocardial amyloid load using quantitative single photon emission computed tomography/computed tomography (SPECT/CT) imaging ATTRv-related cardiomyopathy (ATTRv-CM). furthermore compared them wild-type ATTR-CM (ATTRwt-CM) treated tafamidis.
Plaque destabilization leading to myocardial infarction is observed after surgery even if the intervention of noncardiovascular nature. Mediators peri- or postoperative stress responsible for such events could include catecholamines and lipopolysaccharide (LPS). Monocytes may be involved in atherosclerotic plaques by production matrix metalloproteinases (MMP). We examined whether affect expression MMPs human monocytes/macrophages modulate LPS-stimulated particular these cells. Epinephrine...
Macrophages produce the cytokine oncostatin M (OSM), which beside other functions is also involved in inflammation. The complement component C5a mobilizes and activates these cells at inflammatory sites. We examined effect of on OSM production human monocytes monocyte-derived macrophages.For macrophage transformation peripheral blood were cultivated for 8 to 10 days presence serum. significantly increased antigen as determined by specific ELISA mRNA quantitated real-time polymerase chain...
Serum concentrations of the amino-terminal pro-B-type natriuretic peptide (NT-proBNP) may be used to monitor cardiac function during pregnancy but normal values are not established for this purpose. Therefore, we investigated NT-proBNP in normotensive healthy pregnancies compared a non-pregnant control group. was measured 94 normotensive, pregnant women (32+/-6 years) every five weeks beginning from 12th gestational week (GW) longitudinal study and group 521 (32+/-7 years). Pooled median...