A5057848341- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Sodium Intake and Health
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Peripheral Artery Disease Management
- Thermoregulation and physiological responses
- Angiogenesis and VEGF in Cancer
- Dialysis and Renal Disease Management
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Atomic and Subatomic Physics Research
- Inflammatory mediators and NSAID effects
- Acute Myocardial Infarction Research
- Electrolyte and hormonal disorders
- Respiratory Support and Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Lipoproteins and Cardiovascular Health
- Protease and Inhibitor Mechanisms
- Nutritional Studies and Diet
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Medical University of Vienna
2016-2025
Universitätsklinikum Erlangen
2014-2024
Swiss Group For Clinical Cancer Research
2020-2024
Federal Statistical Office
2023
Charles River Laboratories (United States)
2023
Ashland (United States)
2023
University of Tübingen
2020
Bern University of Applied Sciences
2015-2020
Universitätsklinikum Tübingen
2020
Obesity is closely linked to the insulin resistance syndrome (IRS), type 2 diabetes, and cardiovascular disease, primary cause of morbidity mortality in these patients. Elevated levels C-reactive protein (CRP) interleukin-6 (IL-6), indicating chronic subclinical inflammation, have been associated with features IRS incident disease.We studied cross-sectional longitudinal relation CRP, IL-6, tumor necrosis factor-alpha (TNF-alpha) 37 morbidly obese patients different stages glucose tolerance...
The skin interstitium sequesters excess Na+ and Cl- in salt-sensitive hypertension. Mononuclear phagocyte system (MPS) cells are recruited to the skin, sense hypertonic electrolyte accumulation activate tonicity-responsive enhancer-binding protein (TONEBP, also known as NFAT5) initiate expression secretion of VEGFC, which enhances clearance via cutaneous lymph vessels increases eNOS blood vessels. It is unclear whether this local MPS response osmotic stress important systemic pressure...
High dietary salt intake is associated with hypertension; the prevalence of salt-sensitive hypertension increases age. We hypothesized that tissue Na + might accumulate in hypertensive patients and aging be accompanied by deposition tissue. implemented 23 magnetic resonance imaging to measure content soft tissues vivo earlier, but had not studied essential hypertension. report on a cohort 56 healthy control men women, 57 women The ages ranged from 22 90 years. measurements were made at level...
Hypertension is linked to disturbed total-body sodium (Na(+)) regulation; however, measuring Na(+) disposition in the body difficult. We implemented (23)Na magnetic resonance spectroscopy ((23)Na-MR) and imaging technique ((23)Na-MRI) at 9.4T for animals 3T humans quantify content skeletal muscle skin. compared (23)Na-MRI data with actual tissue measured by chemical analysis animal human tissue. then quantified normal patients primary aldosteronism. found a 29% increase aldosteronism women...
The pathogenesis of left ventricular hypertrophy in patients with CKD is incompletely understood. Sodium intake, which usually assessed by measuring urinary sodium excretion, has been inconsistently linked hypertrophy. However, tissues such as skin and muscle may store sodium. Using 23sodium-magnetic resonance imaging, a technique recently developed for the assessment tissue content humans, we determined at level calf 99 mild to moderate (42 women; median [range] age, 65 [23-78] years). We...
We showed recently that mononuclear phagocyte system (MPS) cells provide a buffering mechanism for salt-sensitive hypertension by driving interstitial lymphangiogenesis, modulating Na + clearance, and increasing endothelial NO synthase protein expression in response to very high dietary salt via tonicity-responsive enhancer binding protein/vascular growth factor C regulatory mechanism. now tested whether isotonic saline deoxycorticosterone acetate (DOCA)-salt treatment leads similar...
The idea that increasing salt intake increases drinking and urine volume is widely accepted. We tested the hypothesis an increase in of 6 g/d would change fluid balance men living under ultra-long-term controlled conditions.Over course 2 separate space flight simulation studies 105 205 days' duration, we exposed 10 healthy to 3 levels (12, 9, or g/d). All other nutrients were maintained constant. studied effect salt-driven changes mineralocorticoid glucocorticoid urinary excretion on...
Chronic kidney disease (CKD) is a common co-morbidity of patients with atherosclerotic vascular disease, and may influence the response to antiplatelet therapy. We, therefore, sought investigate its effect on platelet activation on-treatment residual reactivity.We assessed clopidogrel aspirin in 316 after percutaneous intervention stent implantation. CKD was defined as glomerular filtration rate <60 mL/min/1.73 m(2) according Modification Diet Renal Disease formula. Surface expression...
Platelet-endothelial interactions have a critical role in microcirculatory function, which maintains tissue homeostasis. The subtle equilibrium between platelets and the vessel wall is disturbed by coronavirus disease 2019 (COVID-19), affects all three components of Virchow's triad (endothelial injury, stasis hypercoagulable state). Endotheliitis, vasculitis, glycocalyx degradation, alterations blood flow viscosity, neutrophil extracellular trap formation microparticle shedding are only few...
Beyond lipid lowering, various antiinflammatory properties have been ascribed to statins. Moreover, in vitro studies suggested the presence of anticoagulant effects 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, as lipopolysaccharide (LPS)-induced monocyte tissue factor (TF) was suppressed. In this study, we examined role statins experimental endotoxemia on inflammatory and procoagulant responses vivo.In double-blind, placebo-controlled, parallel-group 20 healthy, male subjects...
The extent of clopidogrel-mediated platelet inhibition varies considerably from one person to the next. Numerous studies have shown that low responders significantly more adverse events after coronary stenting than patients who respond well antithrombotic treatment with clopidogrel. Dihydropyridine calcium-channel blockers (CCBs) inhibit cytochrome P450 3A4 enzyme, which metabolises clopidogrel its active form.To investigate influence CCBs on inhibition.Adenosine-5-diphosphate...
Summary A high on-treatment residual ADP-inducible platelet reactivity in light transmission aggregometry (LTA) has been associated with an increased risk of adverse outcomes after percutaneous coronary intervention (PCI). However, LTA is weakly standardized, and results obtained one laboratory may not be comparable to those another one. We therefore sought determine the test correlating best estimate clopidogrel-mediated inhibition 80 patients on dual antiplatelet therapy elective stent...
Objective Na+ can be stored in muscle and skin without commensurate water accumulation. The aim of this study was to assess H2O with MRI acute heart failure patients before after diuretic treatment a healthy cohort. Methods Nine (mean age 78 years; range 58–87) nine gender-matched controls were studied. They underwent 23Na/1H-MRI at the calf custom-made knee coil. Patients studied therapy. 23Na-MRI gray-scale measurements Na+-phantoms served quantify Na+-concentrations. A fat-suppressed...
Microvascular integrity is a critical factor in myocardial fluid homeostasis. The subtle equilibrium between capillary filtration and lymphatic removal disturbed during pathological processes leading to inflammation, but also hypoxia or due alterations vascular perfusion coagulability. degradation of the glycocalyx as main component endothelial barrier well pericyte disintegration results accumulation interstitial intracellular water. Moreover, dysfunction evokes an increase metabolic waste...
Background. Delayed xenograft rejection (DXR) is characterized by inflammation and vascular thrombosis. Activation of coagulation may occur as a result tissue factor (TF) expression on both activated donor endothelial cells (EC) recipient infiltrating monocytes (Mo). In addition, natural anticoagulants associated with porcine not function adequately across species. Methods. the present study, we examined interaction TF pathway anticoagulant inhibitor, in xenogeneic leukocyte-EC cultures...
Background Delayed xenograft rejection is characterized by platelet activation and fibrin deposition thought to occur independently of complement activation. We have therefore investigated the potential for xenogeneic endothelial cells (EC) regulate conversion prothrombin thrombin, a central component final common pathway coagulation an important agonist. Methods Results Quiescent porcine aortic EC (PAEC) were found convert high levels human thrombin (0.234±0.019 IU/ml) when compared with...