A5023660858- Angiogenesis and VEGF in Cancer
- Lymphatic System and Diseases
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Axon Guidance and Neuronal Signaling
- Sympathectomy and Hyperhidrosis Treatments
- Vascular Malformations and Hemangiomas
- Fibroblast Growth Factor Research
- Vascular Tumors and Angiosarcomas
- Lipid metabolism and disorders
- Kruppel-like factors research
- Cancer Cells and Metastasis
- Congenital heart defects research
- Virus-based gene therapy research
- Lymphatic Disorders and Treatments
- Protease and Inhibitor Mechanisms
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Renal cell carcinoma treatment
- Proteoglycans and glycosaminoglycans research
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Zebrafish Biomedical Research Applications
- Cytokine Signaling Pathways and Interactions
Wihuri Research Institute
2016-2025
University of Helsinki
2016-2025
Ludwig Cancer Research
2000-2023
Institute for Molecular Medicine Finland
2005-2023
Swedish Orphan Biovitrum (United States)
2010-2023
Helsinki University Hospital
2009-2020
Translational Research in Oncology
2014-2020
Institute for Biomedicine
2018
University of Oulu
1982-2017
Oulu University Hospital
2017
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. It controls several processes in cells, such as proliferation, survival, migration, but it not known how these are coordinately regulated to result more complex morphogenetic events, tubular sprouting, fusion, network formation. We show here that VEGF-A angiogenic sprouting the early postnatal retina by guiding filopodial extension from specialized cells situated at tips vascular sprouts....
The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature. Yet, part the cerebrospinal fluid (CSF) drains into cervical lymph nodes (LNs). mechanism CSF entry LNs has been unclear. Here we report surprising finding a vessel network in dura mater mouse brain. We show that dural vessels absorb from adjacent subarachnoid space and brain interstitial (ISF) via glymphatic system. Dural transport deep (dcLNs) foramina at base skull. In transgenic model expressing...
We have recently cloned the human fms-like tyrosine kinase 4 gene FLT4, whose protein product is related to two vascular endothelial growth factor receptors FLT1 and KDR/FLK1. Here expression of FLT4 has been analyzed by in situ hybridization during mouse embryogenesis adult tissues. The mRNA signals first became detectable angioblasts head mesenchyme, cardinal vein, extraembryonally allantois 8.5-day postcoitus (p.c.) embryos. In 12.5-day p.c. embryos, signal decorated developing venous...
No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial factor (VEGF) regulates permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand VEGF receptors VEGFR-3 VEGFR-2, in skin transgenic mice resulted lymphatic, vascular, proliferation vessel enlargement. Thus, VEGF-C induces selective hyperplasia vasculature, which is involved draining interstitial fluid immune function, inflammation, tumor...
We have identified a member of the VEGF family by computer-based homology searching and designated it VEGF-D. VEGF-D is most closely related to VEGF-C virtue presence N- C-terminal extensions that are not found in other members. In adult human tissues, mRNA abundant heart, lung, skeletal muscle, colon, small intestine. Analyses receptor specificity revealed ligand for both receptors (VEGFRs) VEGFR-2 (Flk1) VEGFR-3 (Flt4) can activate these receptors. However, does bind VEGFR-1. Expression...
Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis adult tissues. Unlike VEGF, the related VEGF-C stimulates lymphatic vessels through its specific receptor VEGFR-3. Here it shown that targeted inactivation gene encoding VEGFR-3 resulted defective early mouse embryos. Vasculogenesis occurred, but large became abnormally organized with lumens, leading to fluid accumulation pericardial cavity cardiovascular failure at embryonic...
We have isolated and characterized a novel growth factor for endothelial cells, vascular B (VEGF-B), with structural similarities to (VEGF) placenta factor. VEGF-B was particularly abundant in heart skeletal muscle coexpressed VEGF these other tissues. formed cell-surface-associated disulfide-linked homodimers heterodimerized when coexpressed. Conditioned medium from transfected 293EBNA cells expressing stimulated DNA synthesis cells. Our results suggest that has role angiogenesis cell...