A5061280047- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Global Cancer Incidence and Screening
- AI in cancer detection
- Medical Imaging Techniques and Applications
- Digital Radiography and Breast Imaging
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Advanced MRI Techniques and Applications
- BRCA gene mutations in cancer
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- Genomic variations and chromosomal abnormalities
- Advanced Neuroimaging Techniques and Applications
- Genetic factors in colorectal cancer
- Osteoarthritis Treatment and Mechanisms
- Artificial Intelligence in Healthcare and Education
- Prenatal Screening and Diagnostics
- Radiology practices and education
- Bone and Joint Diseases
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Cancer Genomics and Diagnostics
- Advanced NMR Techniques and Applications
University of Cambridge
2016-2025
NIHR Cambridge Biomedical Research Centre
2016-2025
Cambridge School
2015-2025
Addenbrooke's Hospital
2016-2025
Cambridge University Hospitals NHS Foundation Trust
2015-2025
Barts Health NHS Trust
2023-2024
Norfolk and Norwich University Hospital
2023
Cancer Research UK
2021
Cancer Research UK Cambridge Center
2017-2021
Inserm
2004-2021
PURPOSE: To compare the efficacy of neoadjuvant (NA) docetaxel (DOC) with anthracycline-based therapy and determine NA DOC in patients breast cancer initially failing to respond chemotherapy (CT). PATIENTS AND METHODS: Patients large or locally advanced received four pulses cyclophosphamide 1,000 mg/m2, doxorubicin 50 vincristine 1.5 prednisolone 40 mg (4 × CVAP) for 5 days. Clinical tumor response was assessed. Those who responded (complete [CR] partial [PR]) were randomized receive further...
Federated learning (FL) is a method used for training artificial intelligence models with data from multiple sources while maintaining anonymity, thus removing many barriers to sharing. Here we 20 institutes across the globe train FL model, called EXAM (electronic medical record (EMR) chest X-ray AI model), that predicts future oxygen requirements of symptomatic patients COVID-19 using inputs vital signs, laboratory and X-rays. achieved an average area under curve (AUC) >0.92 predicting...
PURPOSE: To compare the efficacy of neoadjuvant (NA) docetaxel (DOC) with anthracycline-based therapy and determine NA DOC in patients breast cancer initially failing to respond chemotherapy (CT). PATIENTS AND METHODS: Patients large or locally advanced received four pulses cyclophosphamide 1,000 mg/m 2 , doxorubicin 50 vincristine 1.5 prednisolone 40 mg (4 × CVAP) for 5 days. Clinical tumor response was assessed. Those who responded (complete [CR] partial [PR]) were randomized receive...
PURPOSE: To determine whether [ 18 F]-fluorodeoxy-d-glucose ([ F]-FDG) positron emission tomography (PET) can predict the pathologic response of primary and metastatic breast cancer to chemotherapy. PATIENTS AND METHODS: Thirty patients with noninflammatory, large (> 3 cm), or locally advanced cancers received eight doses Dynamic PET imaging was performed immediately before first, second, fifth after last dose treatment. Primary tumors involved axillary lymph nodes were identified, F]-FDG...
BackgroundRetrospective studies provide conflicting interpretations of the effect inherited genetic factors on prognosis patients with breast cancer. The primary aim this study was to determine a germline BRCA1 or BRCA2 mutation cancer outcomes in young-onset cancer.MethodsWe did prospective cohort female recruited from 127 hospitals UK aged 40 years younger at first diagnosis (by histological confirmation) invasive Patients previous malignancy (except non-melanomatous skin cancer) were...
Abstract The European Society of Breast Radiology (EUSOBI) established an International DWI working group. group consists clinical breast MRI experts, physicists, and representatives from large vendors equipment, invited based upon proven expertise in and/or particular DWI, representing 25 sites 16 countries. aims the are (a) to promote use into practice by issuing consensus statements initiate collaborative research where appropriate; (b) define necessary standards provide practical...
Abstract Breast density is an independent risk factor for the development of breast cancer and also decreases sensitivity mammography screening. Consequently, women with extremely dense breasts face increased late diagnosis cancer. These are, therefore, underserved current mammographic screening programs. The results recent studies reporting on contrast-enhanced MRI as a method in provide compelling evidence that this approach can enable important reduction mortality these cost-effective....
The age-based or "one-size-fits-all" breast screening approach does not take into account the individual variation in risk. Mammography reduces death from cancer at cost of overdiagnosis. Identifying risk-stratified strategies with a more favorable ratio overdiagnoses to deaths prevented would improve quality life women and save resources.
Background Digital breast tomosynthesis (DBT) is a three-dimensional mammography technique with the potential to improve accuracy by improving differentiation between malignant and non-malignant lesions. Objectives The objectives of study were compare diagnostic DBT in conjunction two-dimensional (2D) or synthetic 2D mammography, against standard determine if improves detection different types Study population Women (aged 47–73 years) recalled for further assessment after routine screening...
Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients using 13 C magnetic resonance spectroscopic (MRSI) hyperpolarized label exchange between injected [1- C]pyruvate and endogenous lactate pool. Treatment-naïve were recruited: four triple-negative grade 3 cancers; two invasive ductal carcinomas that estrogen progesterone receptor-positive (ER/PR+) HER2/neu-negative (HER2−), one 2 3; ER/PR+ HER2− lobular carcinoma (ILC). Dynamic MRSI was...
We summarise here the information to be provided women and referring physicians about percutaneous breast biopsy lesion localisation under imaging guidance. After explaining why a preoperative diagnosis with is preferred surgical biopsy, we illustrate criteria used by radiologists for choosing most appropriate combination of device type sampling technique Then, describe commonly devices, from fine-needle tissue larger needles, namely core needle vacuum-assisted how mammography, digital...
Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures. We aimed to investigate somatostatin receptor 2 (SST2) as a novel inflammation-specific molecular imaging target LVV. In prospective, observational cohort study, vivo arterial SST2 expression was assessed positron emission tomography/magnetic resonance (PET/MRI) using 68Ga-DOTATATE and 18F-FET-βAG-TOCA. Ex mapping of the performed immunofluorescence microscopy; mass...
The sensitivity of screening mammography for the detection small breast cancers is higher when mammogram read by two readers rather than a single reader. We conducted trial to determine whether performance reader using computer-aided system would match achieved readers.The was designed as an equivalence trial, with matched-pair comparisons between cancer-detection rates reading and those double reading. randomly assigned 31,057 women undergoing routine film at three centers in England...