A5055196026- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- Genetic Associations and Epidemiology
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Bioinformatics and Genomic Networks
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Occupational and environmental lung diseases
- COVID-19 epidemiological studies
- Chronic Lymphocytic Leukemia Research
- Breast Implant and Reconstruction
- Urinary Tract Infections Management
- Burkholderia infections and melioidosis
- Radiomics and Machine Learning in Medical Imaging
- Genomics and Rare Diseases
- Poxvirus research and outbreaks
- Pelvic floor disorders treatments
- Bacillus and Francisella bacterial research
Defence Science and Technology Laboratory
2022-2025
University of Southampton
2013-2022
NIHR Evaluation Trials and Studies Coordinating Centre
2014-2020
Southampton General Hospital
2014-2020
Health Education England
2020
NIHR CRUK Experimental Cancer Medicine Centre
2019
Cancer Research UK
2018-2019
University Hospital Southampton NHS Foundation Trust
2013-2017
Cancer Research UK Clinical Trials Unit
2013
University of Birmingham
2013
BackgroundRetrospective studies provide conflicting interpretations of the effect inherited genetic factors on prognosis patients with breast cancer. The primary aim this study was to determine a germline BRCA1 or BRCA2 mutation cancer outcomes in young-onset cancer.MethodsWe did prospective cohort female recruited from 127 hospitals UK aged 40 years younger at first diagnosis (by histological confirmation) invasive Patients previous malignancy (except non-melanomatous skin cancer) were...
Purpose Biologic heterogeneity is a feature of diffuse large B-cell lymphoma (DLBCL), and the existence subgroup with poor prognosis phenotypic proximity to Burkitt well known. Conventional cytogenetics identifies some patients rearrangements MYC BCL2 and/or BCL6 (double-hit lymphomas) who are increasingly treated more intensive chemotherapy, but biologically coherent clinically useful definition this group required. Patients Methods We defined molecular high-grade (MHG) by applying gene...
Biologically distinct subtypes of diffuse large B-cell lymphoma can be identified using gene-expression analysis to determine their cell origin, corresponding germinal centre or activated B cell. We aimed investigate whether adding bortezomib standard therapy could improve outcomes in patients with these subtypes.
PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the has been good in multiple independent case series, but shown to underestimate specific mortality women diagnosed under age 40. Another limitation use discrete categories for tumour size node status resulting 'step' changes risk estimates on moving between categories. We have refitted using original cohort cases from East Anglia with updated survival time order take into account at...
BackgroundThe interim analysis of the multicentre New EPOC trial in patients with resectable colorectal liver metastasis showed a significant reduction progression-free survival allocated to cetuximab plus chemotherapy compared those given alone. The focus present was assess effect on overall survival.MethodsNew multicentre, open-label, randomised, controlled, phase 3 trial. Adult (aged ≥18 years) KRAS wild-type (codons 12, 13, and 61) or suboptimally metastases WHO performance status 0–2...
The 2022 global mpox outbreak raises questions about how this zoonotic disease established effective human-to-human transmission and its potential for further adaptation. virus is related to an ongoing in Nigeria originally reported 2017, but the evolutionary path linking two remains unclear due a lack of genomic data between 2018, when exportations from were first recorded, 2022, began. Here, 18 viral genomes obtained patients across southern 2019-2020 reveal multiple lineages monkeypox...
Breast cancer at a young age is associated with poor prognosis. The Prospective Study of Outcomes in Sporadic and Hereditary Cancer (POSH) was designed to investigate factors affecting prognosis this patient group. Between 2000 2008, 2956 patients aged 40 years or younger were recruited UK multicenter prospective observational cohort study (POSH). Details tumor pathology, disease stage, treatment received, outcome recorded. Overall survival (OS) distant disease-free interval (DDFI) assessed...
Mainstreaming genetic medicine, increased media coverage and clinical trials for BRCA mutation carriers are leading oncologists into more patient discussions about testing. variants of uncertain significance (VUS) occur in 10–20 % tests. VUS detection introduces additional uncertainty potentially clinician. We aimed to explore the ability breast cancer specialists (BCS) UK correctly respond a report. A survey sent 800 BCS collected demographics data, general knowledge interpretation...
ObjectivesOur aim was to evaluate the safety and efficacy of ipilimumab combined with standard first-line chemotherapy for patients extensive-stage SCLC.MethodsPatients chemotherapy-naive SCLC were treated carboplatin etoposide up six cycles. Ipilimumab, 10 mg/kg, given on day 1 cycles 3 6 every 12 weeks. Response assessed by Evaluation Criteria in Solid Tumors (RECIST), version 1.0, immune-related response criteria. The primary end point 1-year progression-free survival (PFS) according...
To assess clinical and surgical factors affecting local recurrence survival in young breast cancer patients the Prospective study of Outcomes Sporadic versus Hereditary (POSH).
Black ethnic groups have a higher breast cancer mortality than Whites. American studies identified variations in tumour biology and unequal health-care access as causative factors. We compared pathology, treatment outcomes three young patients treated the United Kingdom. Women aged ⩽40 years at diagnosis were recruited to POSH national cohort study (MREC: 00/06/69). Personal characteristics, pathology data collected diagnosis. Follow-up annually. Overall survival (OS) distant relapse-free...
The aim was to investigate if offering symptomatic therapy (Uva-ursi or ibuprofen) alongside a delayed prescription would relieve symptoms and reduce the consumption of antibiotics for adult women presenting with acute uncomplicated urinary tract infection (UTI).A 2 × factorial placebo controlled randomized trial in primary care. participants were 382 aged 18-70 years dysuria, urgency, frequency urination suspected by clinician have lower UTI. interventions Uva-ursi extract and/or ibuprofen...
The objective of this study is to compare the efficacy and cost specialised individually delivered parent training (PT) for preschool children with attention-deficit/hyperactivity disorder (ADHD) against generic group-based PT treatment as usual (TAU). This a multi-centre three-arm, parallel group randomised controlled trial conducted in National Health Service Trusts. participants included were (33–54 months) fulfilling ADHD research diagnostic criteria. New Forest Parenting Programme...
Summary Background Docetaxel and prednisolone chemotherapy (DP) extends survival in metastatic castration resistant prostate cancer (mCRPC). However, emergent clinical resistance is almost inevitable. AKT pathway activation highly prevalent mCRPC contributing to disease progression DP resistance. AZD5363 a potent oral pan-AKT inhibitor with pre-clinical data indicating activity synergy docetaxel. Methods This phase I trial was determine an recommended II dose (RP2D) for combination DP....
Mesothelioma is an incurable, apoptosis-resistant cancer caused in most cases by previous exposure to asbestos and increasing incidence. It represents a growing health burden but remains under-researched, with limited treatment options. Early promising signals of activity relating both PD-L1- PD-1-targeted mesothelioma implicate dependency on this immune checkpoint. There need evaluate checkpoint inhibitors patients relapsed where options are limited. The addition 12 months nivolumab...
BackgroundCisplatin is one of the most ototoxic chemotherapy drugs, resulting in a permanent and irreversible hearing loss up to 50% patients. Cisplatin gentamicin are thought damage through common mechanism, involving reactive oxygen species inner ear. Aspirin has been shown minimise gentamicin-induced ototoxicity. We, therefore, tested hypothesis that aspirin could also reduce ototoxicity from cisplatin-based chemotherapy.MethodsA total 94 patients receiving for multiple cancer types were...
Breast cancer is the most common in younger women (aged ⩽40 years) United Kingdom. PREDICT ( http://www.predict.nhs.uk ) an online prognostic tool developed to help determine best available treatment and outcome for early breast cancer. This study was conducted establish how well performs estimating survival a large cohort of recruited UK POSH study. The includes data from 3000 aged years at diagnosis. Study end points were overall cancer-specific 5, 8, 10 years. Evaluation included model...
Abstract Background It is not clear how the pathology, presentation and outcome for patients who present with de novo metastatic breast cancer (dnMBC) compare those later develop distant metastases. DnMBC uncommon in younger patients. We describe these differences within a cohort of young United Kingdom. Methods Women aged 40 years or first invasive were recruited to prospective POSH national study. Baseline clinicopathological data collected, annual follow-up. Overall survival (OS)...
Troublesome hot flushes and night sweats (HFNS) are experienced by many women after treatment for breast cancer, impacting significantly on sleep quality of life. Cognitive behavioural therapy (CBT) is known to be effective the alleviation HFNS. However, it not if can effectively delivered specialist nurses. We investigated whether group CBT, care nurses (BCNs), reduce impact
Chronic kidney disease (CKD) is a very common long-term condition and powerful risk factor for cardiovascular (CVD). Low-dose aspirin of proven benefit in the secondary prevention myocardial infarction (MI) stroke people with pre-existing CVD. However, without CVD, rates MI are much lower, benefits primary CVD largely balanced by an increased bleeding. People CKD at greatly so absolute likely to be greater than lower-risk groups, even if relative same. Post hoc evidence suggests may...
<title>Abstract</title> The development of humane endpoints is critical for refining scientific studies involving animals. Body weight and clinical signs disease data collected in four recent assessing medical countermeasures utility against the melioidosis mice, was further analyzed. This work used this information to ascertain if a suitable alternative endpoint could be identified. A total 66 possible were explored, which varied threshold values ‘percentage body loss post-challenge’ ‘the...
Abstract Background Young patients presenting to surgical clinics with breast cancer are usually aware of their family history and frequently believe that a positive may adversely affect prognosis. Tumour pathology outcomes were compared in young British without cancer. Methods Prospective Outcomes Sporadic versus Hereditary (POSH) is large prospective cohort study women aged less than 41 years diagnosed treated the UK using modern oncological management. Personal characteristics, tumour...