A5038265443- Delphi Technique in Research
- Appendicitis Diagnosis and Management
- Hemoglobinopathies and Related Disorders
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Intestinal Malrotation and Obstruction Disorders
- Iron Metabolism and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Food Allergy and Anaphylaxis Research
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroscience of respiration and sleep
- Hearing, Cochlea, Tinnitus, Genetics
- Eosinophilic Esophagitis
- Allergic Rhinitis and Sensitization
- High Altitude and Hypoxia
- Diversity and Career in Medicine
- Healthcare Operations and Scheduling Optimization
- Lysosomal Storage Disorders Research
- Cancer Risks and Factors
- Hip and Femur Fractures
- Infant Development and Preterm Care
- Health Policy Implementation Science
- Hearing Loss and Rehabilitation
University of Southampton
2014-2025
Wessex Institute of Technology
2011-2018
Faculty (United Kingdom)
2018
Guy's and St Thomas' NHS Foundation Trust
2015
St Thomas' Hospital
2015
University Hospital Southampton NHS Foundation Trust
2015
While non-operative treatment has emerged as an alternative to surgery for the of uncomplicated acute appendicitis in children, comparative patient-centred outcomes are not well documented. We investigated these a feasibility randomised trial. Of 57 participants, data were available 26. Compared with appendicectomy, children allocated reported higher short-term quality life scores, shorter duration requiring analgesia, more rapid return normal activities and parental absence from work. These...
The impact of living with metastatic breast cancer (MBC) is considerable and psychosocial support can be beneficial. Mindfulness-based stress reduction (MBSR) help self-management anxiety, depression, quality life (QoL), fatigue has been evaluated in early-stage but not MBC. This study investigated the acceptability feasibility providing MBSR for women MBC introducing into a National Health Service (NHS) setting. A mixed methods convergent design was used. Eligible MBC, an Eastern...
Background Preschool hyperactivity is an early risk factor for adult mental health problems and criminality. Little known about; (a) the patterns of long‐term service costs associated with this behavioural marker in general population (b) specific factors predicting hyperactivity‐related costs. We undertook a prospective study investigating associations between preschool average individual annual up to late adolescent young adulthood. Methods One‐hundred seventy individuals rated as...
Abstract Objectives To determine the clinical effectiveness and cost of including emollient bath additives in management eczema children. Design Pragmatic randomised open label superiority trial with two parallel groups. Setting 96 general practices Wales western southern England. Participants 483 children aged 1 to 11 years, fulfilling UK diagnostic criteria for atopic dermatitis. Children very mild who bathed less than once weekly were excluded. Interventions intervention group prescribed...
Background Although non-operative treatment is known to be effective for the of uncomplicated acute appendicitis in children, randomised trial data comparing important outcomes with those appendicectomy are lacking. Objectives The objectives were ascertain feasibility conducting a multicentre controlled clinical effectiveness and cost-effectiveness pathway children. Design This was mixed-methods study, which included trial, embedded parallel qualitative survey studies, health economic study...
The objective of this study is to compare the efficacy and cost specialised individually delivered parent training (PT) for preschool children with attention-deficit/hyperactivity disorder (ADHD) against generic group-based PT treatment as usual (TAU). This a multi-centre three-arm, parallel group randomised controlled trial conducted in National Health Service Trusts. participants included were (33–54 months) fulfilling ADHD research diagnostic criteria. New Forest Parenting Programme...
<b>Objective</b> To assess the claim in a Cochrane review that mammographic breast cancer screening could be doing more harm than good by updating analysis Forrest report, which led to United Kingdom. <b>Design</b> Development of life table model, replicated Forrest's results before and extending them with data from relevant systematic reviews, trials, other models based on purposive literature searches. <b>Participants</b> Women aged 50 over invited for screening. <b>Main outcome...
Visual Electro-Diagnostic Testing (EDTs) are a highly specialised service in the NHS. The high cost of tests and paucity trained visual electrophysiologists has resulted very few services across UK and, when combined with increasing patient backlogs, caused significant travel burden variable waiting times. Here, we study potential for impact on patients by adding screening step to traditional referral pathways using an Electroretinogram (ERG) test from relatively inexpensive, portable,...
Currently, the routine treatment for acute appendicitis in United Kingdom is an appendicectomy. However, there increasing scientific interest and research into non-operative of adults children. While a number studies have investigated adults, this cannot be applied to paediatric population. Ultimately, we aim perform UK-based multicentre randomised controlled trial (RCT) test clinical cost effectiveness uncomplicated children, as compared with First, will undertake feasibility study assess...
Objective To establish the feasibility of a multicentre randomised controlled trial to assess effectiveness and cost-effectiveness non-operative treatment pathway compared with appendicectomy in children uncomplicated acute appendicitis. Design Feasibility embedded qualitative study inform recruiter training optimise recruitment design future definitive trial. Setting Three specialist paediatric surgery centres UK. Patients Children (aged 4–15 years) clinical diagnosis Interventions...
In addition to pain, sickle cell anaemia (HbSS) complications include neurocognitive difficulties in attention and processing speed associated with low daytime night-time oxygen saturation compounded by obstructive sleep apnoea (OSA). the general population OSA is treated continuous positive airways pressure (CPAP). The aim of this single-blind, randomised, controlled phase II trial compare auto-adjusting CPAP (APAP) standard care alone individuals HbSS determine whether intervention...
Childhood eczema is very common. Treatment often includes emollient bath additives, despite there being little evidence of their effectiveness.To determine the clinical effectiveness and cost-effectiveness additives in management childhood eczema.Pragmatic, randomised, open-label, multicentre superiority trial with two parallel groups.Ninety-six general practices Wales, west England southern England. Invitation by personal letter or opportunistically.Children aged between 12 months years...
Abstract Background Pregnancies in women with sickle cell disease (SCD) are associated a higher risk of and pregnancy complications. Limited options exist for treating SCD during pregnancy. Serial prophylactic exchange blood transfusion (SPEBT) has been shown to be effective outside pregnancy, but evidence is lacking regarding its use The aim this study assess the feasibility acceptability conducting future phase 3 randomised controlled trial (RCT) establish clinical cost effectiveness SPEBT...
The New Forest Parenting Programme (NFPP) is a home-delivered, evidence-based parenting programme to target symptoms of attention-deficit/hyperactivity disorder (ADHD) in preschool children. It has been adapted for use with 'hard-to-reach' or 'difficult-to-treat' This trial will compare the adapted-NFPP generic group-based programme, Incredible Years (IY), which recommended children preschool-type ADHD symptoms. multicentre randomized controlled comprises three arms: adapted-NFPP, IY and...
Sickle cell anaemia (SCA) is an inherited disorder of haemoglobin. Patients experience long-term health care problems, affecting quality life (QOL) including frequent acute pain, which difficult to document in trials except as hospital admissions. Pilot data suggests that overnight respiratory support, either supplementary oxygen or auto-adjusting continuous positive airways pressure (APAP), safe and may have clinical benefit. This pilot trial aims determine intervention more acceptable...
Introduction Bath emollients are widely prescribed for childhood eczema, yet evidence of their benefits over direct application is lacking. Objectives To determine the clinical and cost-effectiveness adding bath emollient to standard management eczema in children Methods analysis Design : Pragmatic open 2-armed parallel group randomised controlled trial. Setting General practitioner (GP) practices England Wales. Participants Children aged 12 months less than years with excluding inactive or...
<h3>Objective</h3> To investigate the effects in adolescence of bilateral permanent childhood hearing loss (PCHL) > 40 dB and exposure to universal newborn screening (UNHS) on societal costs accrued over preceding 12 months. <h3>Design, setting, participants</h3> An observational cohort study a sample 110 adolescents aged 13–20 years, 73 with PCHL 37 normally comparison group (HCG) closely similar respect place date birth those PCHL, drawn from 1992–1997 157 000 births Southern England,...
This randomised crossover trial compared nocturnal auto-adjusting continuous positive airway pressure (APAP) and oxygen therapy (NOT) in adults children with sickle cell anaemia, patient acceptability as the primary outcome. Secondary outcomes included pulmonary physiology (adults), safety, daily pain during interventions washout documented using tablet technology. Inclusion criteria were age > 8 years ability to use an iPad collect data. Trial participation was 4 weeks; week 1 involved...
Background Acute appendicitis is one of the most common acute surgical emergencies in children and accounts for an annual cost approximately £50 million to National Health Service. Investigating alternative treatment options offers best prospect enhancing quality care patients potential opportunities savings through better allocative efficiency. A feasibility randomised controlled trial (RCT) comparing a non-operative pathway with appendicectomy uncomplicated underway (CONTRACT RCT). Aims...
Patient-reported outcomes measures in clinical trials ensure that evaluations of effectiveness focus on are important to patients. In relapsing-remitting conditions, such as eczema, repeated measurements may allow a more accurate reflection disease burden and treatment effect than less frequent measurements. We asked parents/carers children with eczema taking part trial bath emollients complete weekly questionnaires for 16 weeks. The objective this study was determine the acceptability...
Physical rehabilitation delivered early following admission to the intensive care unit (ICU) has potential improve short-term and long-term outcomes. The use of supine cycling together with other techniques as a method introducing earlier in patient journey. aim study is determine feasibility delivering designed protocol randomised clinical trial comparing protocolised programme including usual care. This will inform larger multicentre study. 90 acute medical patients from two mixed...