A5053540185- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Anesthesia and Pain Management
- Diabetes Management and Research
- Cardiac Arrhythmias and Treatments
- Pancreatic function and diabetes
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Kawasaki Disease and Coronary Complications
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Shoulder Injury and Treatment
- Statistical Methods in Clinical Trials
- Nausea and vomiting management
- Neuroscience of respiration and sleep
- Hemoglobinopathies and Related Disorders
- Heart Failure Treatment and Management
- Iron Metabolism and Disorders
- Thyroid Disorders and Treatments
- Endometrial and Cervical Cancer Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neonatal Respiratory Health Research
- Lipoproteins and Cardiovascular Health
- Mobile Health and mHealth Applications
University College London
2017-2025
Electrophysiology Research Foundation
2014-2025
Arthritis Northwest
2022-2025
MRC Clinical Trials Unit at UCL
2017-2024
Comprehensive Clinical Trials
2022-2023
Seattle University
2016-2022
Memorial Sloan Kettering Cancer Center
2022
Aptevo Therapeutics (United states)
2012-2021
Seattle Children's Hospital
2010-2021
Virginia Mason Medical Center
2013-2019
<h3>Objective</h3> To assess the long-term cure rate for treatment of lentigo maligna (LM) and melanoma (LMM) by means a staged, margin-controlled, vertical-edged excision with rush permanent specimens radial sectioning technique. <h3>Design</h3> Retrospective follow-up study. <h3>Setting</h3> University-affiliated private-practice dermatologic surgery clinics. <h3>Patients</h3> Fifty-nine patients treated 55 LMs 7 LMMs between January 1, 1990, December 31, 2001. <h3>Interventions</h3> The...
Adductor canal blocks have shown promise in reducing postoperative pain total knee arthroplasty patients. No randomized, controlled studies, however, evaluate the opioid-sparing benefits of a continuous 0.2% ropivacaine infusion at adductor canal. We hypothesized that block would decrease opioid consumption.Eighty subjects presenting for primary unilateral were randomized to receive either ultrasound-guided with or sham catheter. All received preoperative single-injection femoral nerve...
Severe local anesthetic systemic toxicity (LAST) is a rare event, the management of which might best be learned using high-fidelity simulation. In its 2010 Practice Advisory, American Society Regional Anesthesia and Pain Medicine (ASRA) created medical checklist to aid in LAST. We hypothesized that trainees provided with this would manage simulated episode LAST more effectively than those without it. A secondary aim study was assess ASRA Checklist's usability readability.Trainees undergoing...
Background Metabolic syndrome increases risk for atherosclerotic coronary artery disease, and its prevalence with increasing age body mass index. Adults congenital heart disease ( ACHD ) are now living longer accruing factors. However, the of metabolic in patients is unknown. Methods Results We conducted a retrospective cohort study at our center to quantify an population. Using case‐control matching, we constructed comparable control group from population‐based sample 150 104 adults....
OBJECTIVE To assess the effects of canagliflozin, a sodium glucose cotransporter 2 inhibitor, on glycemic parameters and measures variability assessed by 9-point self-monitoring blood (SMBG) continuous monitoring (CGM) profiles, patient-reported outcomes as an add-on to insulin among participants with type 1 diabetes. RESEARCH DESIGN AND METHODS In this randomized, double-blind study, 351 received canagliflozin 100 or 300 mg placebo for 18 weeks. Change from baseline in daily mean SD was...
Abstract Background COVID-19 causes acute respiratory distress syndrome (ARDS) and depletes the lungs of surfactant, leading to prolonged mechanical ventilation death. The feasibility safety surfactant delivery in ARDS patients have not been established. Methods We performed retrospective analyses data from receiving off-label use exogenous natural during pandemic. Seven PCR positive received liquid Curosurf (720 mg) 150 ml normal saline, divided into five 30 aliquots) delivered via a...
Triiodothyronine levels decrease in infants and children after cardiopulmonary bypass. We tested the primary hypothesis that triiodothyronine (T3) repletion is safe this population produces improvements postoperative clinical outcome.The TRICC study was a prospective, multicenter, double-blind, randomized, placebo-controlled trial younger than 2 years old undergoing heart surgery with Enrollment stratified by surgical diagnosis. Time to extubation (TTE) outcome. Patients received intravenous...
Abstract Background The interscalene nerve block provides analgesia for shoulder surgery, but is associated with diaphragm paralysis. One solution may be performing brachial plexus blocks more distally. This noninferiority study evaluated at the supraclavicular and anterior suprascapular levels, comparing them individually to approach. Methods hundred-eighty-nine subjects undergoing arthroscopic surgery were recruited this double-blind trial randomized interscalene, supraclavicular, or using...
OBJECTIVES: Patients with Kawasaki disease can develop life-altering coronary arterial abnormalities, particularly in those resistant to intravenous immunoglobulin (IVIg) therapy. We tested the tumor necrosis factor α receptor antagonist etanercept for reducing both IVIg resistance and artery (CA) progression. METHODS: In a double-blind multicenter trial, patients received either (0.8 mg/kg; n = 100) or placebo (n 101) subcutaneously starting immediately after infusion. was primary outcome...
<h3>Background and Objectives</h3> Continuous brachial plexus blocks at the interscalene level are associated with known diaphragm dysfunction from phrenic nerve paresis. More distal along may provide postsurgical analgesia while potentially having less effect on function. interscalene, continuous supraclavicular, suprascapular were evaluated for respiratory function after total shoulder arthroplasty. <h3>Methods</h3> After ethics board approval, subjects presenting arthroplasty planned...
Background: Atrial fibrillation is the most common type of sustained cardiac arrhythmia, but recent trials have identified no clear advantage rhythm control over rate control. Consequently, economic factors often play a role in guiding treatment selection. Objective: To estimate cost-effectiveness rhythm-control versus rate-control strategies for atrial Fibrillation Follow-up Investigation Rhythm Management (AFFIRM). Design: Retrospective evaluation. Nonparametric bootstrapping was used to...
<h3>Background and Objectives</h3> The placement of thoracic epidurals can be technically challenging requires a thorough understanding neuraxial anatomy. Although ultrasound imaging the spine has been described, no outcome studies on use this have performed. We evaluated whether preprocedural would facilitate process epidural catheterization. <h3>Methods</h3> Subjects undergoing or upper abdominal surgery with planned at T10 higher were enrolled in randomized double-blind study. allocated...
Background Generalised anxiety disorder and symptoms are associated with poor physical, emotional social functioning frequent primary acute care visits. We investigated recent temporal trends in related mental illness UK general practice. Aims The aims of this analysis to examine changes recording generalised initial pharmacologic treatments. Method Annual incidence rates diagnoses were calculated from 795 practices contributing Health Improvement Network (THIN) database between 1998 2018....
Prevalent atrial fibrillation (AF) is associated with excess cardiovascular (CV) death (D) and hospitalizations (H) in heart failure (HF) preserved ejection fraction (pEF). We evaluated if it had an independent role CVD HFpEF studied its impact on cause-specific mortality HF morbidity.
OBJECTIVE The study was undertaken because it unknown whether the duration of type 2 diabetes modifies effects sodium–glucose cotransporter inhibitor canagliflozin on cardiovascular (CV) and kidney outcomes. RESEARCH DESIGN AND METHODS This post hoc analysis Canagliflozin Cardiovascular Assessment Study (CANVAS) Program (N = 10,142) Evaluation Effects Renal Outcomes in Participants With Diabetic Nephropathy (CREDENCE) trial 4,401) evaluated hazard ratios 95% CIs using Cox proportional...
<h3>Background and Objectives</h3> Esophageal cancer is a leading cause of death worldwide, esophageal resection associated with extremely high perioperative morbidity mortality. A clinical pathway for esophagectomy patients in which anesthetic care both integral standardized has not been described previously. <h3>Methods</h3> continuously refined the patient developed at Virginia Mason Medical Center over past 22 years. Ongoing data collection records demographics, comorbidities, tumor...