A5066830595- Neurotransmitter Receptor Influence on Behavior
- Blood Pressure and Hypertension Studies
- Eicosanoids and Hypertension Pharmacology
- Analytical Methods in Pharmaceuticals
- Renal function and acid-base balance
- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Substance Abuse Treatment and Outcomes
- Forensic Toxicology and Drug Analysis
- Pharmacogenetics and Drug Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Digital Mental Health Interventions
- Protein Hydrolysis and Bioactive Peptides
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Treatment of Major Depression
- Hormonal Regulation and Hypertension
- Alcohol Consumption and Health Effects
- Neuroblastoma Research and Treatments
- Consumer Attitudes and Food Labeling
- Ear and Head Tumors
- Cholesterol and Lipid Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Cardiovascular Syncope and Autonomic Disorders
Baylor College of Medicine
2017
National Institute on Drug Abuse
2007-2015
Henry M. Jackson Foundation
2012
National Institutes of Health
2005-2011
Office of Extramural Research
2006
University of Iowa
2006
University of California, Los Angeles
2006
Alzheimer’s Disease Neuroimaging Initiative
2006
Minneapolis VA Medical Center
2006
Geriatric Research Education and Clinical Center
2006
ABSTRACT Aims Topiramate has shown efficacy at facilitating abstinence from alcohol and cocaine abuse. This double‐blind, placebo‐controlled out‐patient trial tested topiramate for treating methamphetamine addiction. Design Participants ( n = 140) were randomized to receive or placebo (13 weeks) in escalating doses 50 mg/day the target maintenance of 200 weeks 6–12 (tapered week 13). Medication was combined with weekly brief behavioral compliance enhancement treatment. Setting The conducted...
Arthritis and hypertension are frequent comorbidities in the elderly hypertensive population. Nonsteroidal anti-inflammatory drugs often used to relieve pain arthritic patients but a side effect is sodium retention consequent elevation of blood pressure (BP). The dihydropyridine calcium blocking relatively independent intake, whereas angiotensin-converting enzyme (ACE) inhibitors' effects can be blunted by high-sodium diet. This study compared indomethacin with placebo essential who had been...
1 Ranitidine pharmacokinetics were studied in six healthy volunteers. Following an overnight fast, doses of 20 mg intravenously 20, 40 and 100 orally with a standard meal, administered to each subject on separate occasions. 2 intravenous administration there was bioexponential decline plasma levels from 576 +/- 56 ng/ml at 4 min 10 8 h. The distribution half-life (T 1/2 alpha) 6.1 0.9 min, elimination beta) 1.9 0.1 h, the volume (Vd 115 7 l systemic clearance (Cltp) 709 62 ml/min. 3 oral...
A variety of neuropharmacological strategies are being pursued in the search for an effective treatment methamphetamine (Meth) addiction. In this study, we investigated safety and potential efficacy aripiprazole, antipsychotic agent acting on both dopamine serotonin systems. We conducted a double-blind in-patient clinical pharmacology study to assess interactions between intravenous (i.v.) Meth (15 mg 30 mg) oral aripiprazole mg). addition, effects abstinence-related craving cue-induced were...
Dietary fibre and ketone bodies: reduced urinary 3-hydroxybutyrate excretion in diabetics on guar is known to modify carbohydrate absorption metabolism both normal diabetic individuals.'-3Except for reports the action of certain forms reducing serum cholesterol concentrations,3 however, no attention has been given other changes lipid metabolism.Since urine testing bodies still a major part clinical assessment diabetic, we have looked at effect gum output 3-hydroxybutyric acid (3-OHB)...
Atomoxetine has been considered as an agonist replacement therapy for cocaine. We investigated the safety of interaction atomoxetine with cocaine and also whether cognitive function was affected by during short-term administration.In a double-blind placebo-controlled inpatient study 20 cocaine-dependent volunteers, participants received 80 mg daily followed 100 5 days each. On fourth fifth day at each dose, (20 40 mg) infused intravenously in sequential sessions.Preinfusion mean systolic...
Ketanserin, a 5HT2-receptor blocking drug was given to 17 patients with essential hypertension. Satisfactory control achieved in 13 patients. Control not as satisfactory when once daily. There no rebound effect the ceased. Side-effects were few. Ketanserin reduce blood pressure moderate
Ten patients who had their blood pressure controlled with enalapril (10 mg, n = 4; 20 6) and 10 control subjects on Perindopril (4 6; 8 4) entered a double-blind crossover study. They received placebo or the active drug 1 week apart measured at 0, 2, 3, 4, 24 h. Then they crossed over to other angiotensin-converting enzyme inhibitors mg ≃ enalapril) double- blind study was repeated. Blood 2 4 h after administration similar both drugs (perindopril 150 ± 2/80 1; 2/81 1). Twenty-four of...
The interim results of a study using Captopril (SQ 14225) and hydrochlorothiazide in the management moderate hypertension are presented. Both drugs, when used individually, had significant antihypertensive effect. When together, adequate blood pressure control was achieved all, except one, 14 patients. Probable reactions to therapy included loss taste, rash, bronchospasm flushing after eating.
SUMMARY 1. The study was undertaken in male patients aged 61–73 years with essential hypertension. 2. had previously their blood pressure controlled the drug studied. 3. A randomized crossover compared effect of different doses on peak (3h) and trough (24h) to placebo. 4. All used lowered at response responses angiotensin converting enzyme inhibitors were similar. felodipine some dose dependency. 5. Trough not from placebo enalapril, 5 10 mg, perindopril, 2mg, felodipine, 2.5 mg but 20 40 4...
The HIV risk-taking behavior scale (HRBS) is an 11-item instrument designed to assess the risks of infection due self-reported injection drug use and sexual behavior. A retrospective analysis was performed on HRBS data collected from approximately 1,000 participants pooled across seven clinical trials pharmacotherapies for either treatment cocaine-dependence or methamphetamine-dependence. Analysis faced three important challenges. sample contained a high proportion missing assessments after...