A5059281639- Neurotransmitter Receptor Influence on Behavior
- Substance Abuse Treatment and Outcomes
- Neurological disorders and treatments
- Cannabis and Cannabinoid Research
- Heart Rate Variability and Autonomic Control
- Telemedicine and Telehealth Implementation
- Forensic Toxicology and Drug Analysis
- COVID-19 and Mental Health
- Transcranial Magnetic Stimulation Studies
- Opioid Use Disorder Treatment
- Traumatic Brain Injury Research
- Treatment of Major Depression
- Memory and Neural Mechanisms
- Digital Mental Health Interventions
- Vagus Nerve Stimulation Research
- Receptor Mechanisms and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- Psychedelics and Drug Studies
- Sleep and Wakefulness Research
- Schizophrenia research and treatment
- Nicotinic Acetylcholine Receptors Study
- Sleep and related disorders
- Prenatal Substance Exposure Effects
Blanchette Rockefeller Neurosciences Institute
2019-2025
West Virginia University
2017-2025
Center for Psychiatry and Behavioral Medicine
2023
West Virginia University Hospitals
2020
Baylor College of Medicine
2008-2016
Michael E. DeBakey VA Medical Center
2012-2016
University of Virginia
2015
University of Oklahoma Health Sciences Center
2014-2015
University of Houston
2012
University of California, Los Angeles
2006-2008
Ketamine produces rapid antidepressant effects in treatment-resistant depression (TRD), but the magnitude of response varies considerably between individual patients. Brain-derived neurotrophic factor (BDNF) has been investigated as a biomarker treatment and implicated mechanism action ketamine. We evaluated plasma BDNF associations with symptoms 22 patients TRD enrolled randomized controlled trial ketamine compared to an anaesthetic control (midazolam). significantly increased levels...
While current treatments for substance use disorder (SUD) are beneficial, success rates remain low and treatment outcomes complicated by co-occurring SUDs, many of which without available medication treatments. Research involving neuromodulation SUD has recently gained momentum. This study evaluated two doses (60 90 W) Low Intensity Focused Ultrasound (LIFU), targeting the bilateral nucleus accumbens (NAc), in individuals with SUD.Four participants (three male), who were receiving...
Previous research has focused on developing theories of addiction that may explain behavior in cocaine- and methamphetamine-dependent individuals. The primary goal this report was to compare contrast the prevalence self-reported measures impulsivity, depression, lifetime stress sensation-seeking healthy controls versus individuals with cocaine or methamphetamine use disorders. Twenty-nine disorders 31 were matched control participants several demographic variables. All administered...
The primary objective of this study was to compare and contrast psychotic symptoms reported by cocaine‐ methamphetamine‐dependent individuals. Participants included 27 cocaine‐dependent 25 males, as well 15 18 females. After screening, participants were excluded if they met criteria for any Axis I diagnosis other than nicotine dependence, or methamphetamine cocaine dependence (ie, had use either but both). administered the newly developed Psychotic Symptom Assessment Scale (PSAS), which...
The COVID-19 pandemic has been associated with increased psychological distress, signaling the need for mental health services in context of stay-at-home policies.
There were more than 107,000 drug overdose deaths in the US 2021, most ever recorded. Despite advances behavioral and pharmacological treatments, over 50% of those receiving treatment for opioid use disorder (OUD) experience recurrence (relapse). Given prevalence OUD other substance disorders (SUDs), high rate recurrence, number deaths, novel strategies are desperately needed. The objective this study was to evaluate safety feasibility deep brain stimulation (DBS) targeting nucleus accumbens...
Abstract In the present paper, we determine localization and developmental regulation of N‐cadherin in embryonic rat nerves examine role this system. We also identify a major transition architecture relating it to expression. find that early nerves, is primarily expressed Schwann cell precursors. Pronounced expression seen at distal nerve fronts where these cells associate with growth cones, proximal ends, boundary cap cells. Unexpectedly, downregulated as precursors generate cells,...
Background Preclinical research implicates dopaminergic and noradrenergic mechanisms in mediating the reinforcing effects of drugs abuse, including cocaine. The objective this study was to evaluate impact treatment with α1 receptor antagonist doxazosin on positive subjective Methods Thirteen non-treatment seeking, cocaine-dependent volunteers completed single-site, randomized, placebo-controlled, within-subjects study. In one phase received placebo other they doxazosin, order counterbalanced...
Introduction: Virtual reality (VR) has been shown to be effective in eliciting responses nicotine cues cigarette smokers. The primary aim of this study was investigate whether cigarette-deprived smokers would exhibit increased craving and changes heart rate when viewing related as compared non-smoking a VR environment, the secondary assess extent which self-assessed measures withdrawal dependence correlated with craving. Methods: Nicotine-dependent were recruited for 2 day study. On Day 1,...
Ingestible electronics can transform how patients are diagnosed and treated across many conditions. We developed an ingestible vitals-monitoring pill (VM pill) capable of monitoring vital signs including respiratory rate heart rate. VM performance was evaluated in a swine model opiate overdose human trial sleep laboratory. Sleep studies involve admission to facility, placement multiple skin sensors, overnight observation. hypothesized that the could diagnose clinically significant changes...
A variety of neuropharmacological strategies are being pursued in the search for an effective treatment methamphetamine (Meth) addiction. In this study, we investigated safety and potential efficacy aripiprazole, antipsychotic agent acting on both dopamine serotonin systems. We conducted a double-blind in-patient clinical pharmacology study to assess interactions between intravenous (i.v.) Meth (15 mg 30 mg) oral aripiprazole mg). addition, effects abstinence-related craving cue-induced were...