A5034640723- Treatment of Major Depression
- Tryptophan and brain disorders
- Anesthesia and Sedative Agents
- Mental Health Research Topics
- Anesthesia and Pain Management
- Nausea and vomiting management
- Electroconvulsive Therapy Studies
- Functional Brain Connectivity Studies
- Veterinary Pharmacology and Anesthesia
- Antibiotics Pharmacokinetics and Efficacy
- Sleep and Work-Related Fatigue
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Libraries and Information Services
- Sleep and related disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Traumatic Brain Injury and Neurovascular Disturbances
- Growth Hormone and Insulin-like Growth Factors
- Tracheal and airway disorders
- Analytical Methods in Pharmaceuticals
- Genetics and Neurodevelopmental Disorders
- Sleep and Wakefulness Research
- Hospital Admissions and Outcomes
- Healthcare Technology and Patient Monitoring
- Effects and risks of endocrine disrupting chemicals
Baylor College of Medicine
2012-2024
Michael E. DeBakey VA Medical Center
2012-2021
Purdue University West Lafayette
2019
Icahn School of Medicine at Mount Sinai
2013
National Cheng Kung University
2013
Intravenous ketamine demonstrated rapid antidepressant effects in an optimized study design, improving depression severity 64% of treatment-resistant patients 24 hours after a single dose. The double-blind trial provides evidence for the role N-methyl-d-aspartate glutamate receptor depression, not currently activated by existing drugs.
Background Preliminary evidence suggests intravenous ketamine has rapid effects on suicidal cognition, making it an attractive candidate for depressed patients at imminent risk of suicide. In the first randomized controlled trial using anesthetic control condition, we tested ketamine's acute explicit cognition and a performance-based index implicit (Implicit Association Test; IAT) previously linked to behavior. Method Symptomatic with treatment-resistant unipolar major depression (inadequate...
Ketamine produces rapid antidepressant effects in treatment-resistant depression (TRD), but the magnitude of response varies considerably between individual patients. Brain-derived neurotrophic factor (BDNF) has been investigated as a biomarker treatment and implicated mechanism action ketamine. We evaluated plasma BDNF associations with symptoms 22 patients TRD enrolled randomized controlled trial ketamine compared to an anaesthetic control (midazolam). significantly increased levels...
Electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine are both currently used for treatment-resistant major depression, but the comparative effectiveness of two treatments remains uncertain.We conducted an open-label, randomized, noninferiority trial involving patients referred to ECT clinics depression. Patients with depression without psychosis were recruited assigned in a 1:1 ratio receive or ECT. During initial 3-week treatment phase, received either three times per week...
Importance The ELEKT-D: Electroconvulsive Therapy (ECT) vs Ketamine in Patients With Treatment Resistant Depression (TRD) (ELEKT-D) trial demonstrated noninferiority of intravenous ketamine ECT for nonpsychotic TRD. Clinical features that can guide selection may inform shared decision-making patients with Objective To evaluate whether selected clinical were associated differential improvement ECT. Design, Setting, and Participants This secondary analysis an open-label randomized was a...
The purpose of this study was to evaluate the effects acute, oral modafinil (200 mg) exposure on daytime sleepiness in methamphetamine (Meth)-dependent individuals. Eighteen Meth-dependent subjects were enrolled a 7-d inpatient and administered placebo or day 6 counter-condition 7 (randomized) protocol. Subjects completed several subjective daily assessments (such as Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Beck Depression Inventory visual analogue scale) throughout protocol...
Pain is the primary complaint and main reason for prolonged recovery after laparoscopic cholecystectomy. The authors hypothesized that patients undergoing cholecystectomy will have less pain four hours surgery when receiving maintenance of anesthesia with propofol compared to isoflurane, desflurane, or sevoflurane. In this prospective, randomized trial, 80 scheduled were assigned propofol, sevoflurane anesthesia. Our outcome was measured on numeric analog scale surgery. We also recorded...
Background The impact of sleep deprivation on neurocognitive performance is a significant concern to both the health patients and physicians caring for them, as demonstrated by Accreditation Council Graduate Medical Education enforced resident work hours. This study examined effects an overnight call at level 1 trauma hospital faculty anesthesiologists. Methods Eleven anesthesiologists completed series computerized tests that were designed evaluate different areas neurocognition, such...
a dor é principal queixa e também o motivo de recuperação prolongada pós‐colecistectomia laparoscópica. A nossa hipótese foi que os pacientes submetidos à colecistectomia laparoscópica apresentariam menos quatro horas após cirurgia se recebessem manutenção anestésica com propofol em comparação isoflurano, desflurano ou sevoflurano. neste estudo prospectivo randômico, 80 agendados para foram designados receber propofol, sevoflurano da anestesia. Nosso desfecho primário mensurada escala...
More than eleven million U.S. Veterans are at least 65 years of age, an age group which almost 20% suffers from clinically significant depressive symptoms. Available pharmacological treatments suboptimal for patients, including veterans, with late-life depression. Ketamine has emerged as a potentially promising rapid-acting therapy treatment-resistant depression (TRD). However, few studies have examined the safety, tolerability and efficacy ketamine older adults TRD (LL-TRD). This study uses...
Advancement of the endotracheal tube through a fibreoptic scope can sometimes prove to be challenging in obese patients. The Parker Flex-Tip was developed with curved and tapered distal tip facilitate easier placement trachea. This study examined use as compared standard tubes patients body mass index 30 or greater.Sixty undergoing surgery requiring general anaesthesia were randomised into two groups. Using scope, one group intubated other polyvinyl Portex tube. time for intubation number...
el dolor es principal motivo de queja y también la razón una prolongada recuperación tras colecistectomía laparoscópica. Nuestra hipótesis fue que los pacientes sometidos a laparoscópica tenían menos 4 h después cirugía cuando recibían propofol para anestesia en comparación con isoflurano, desflurano o sevoflurano. este estudio prospectivo aleatorizado, 80 programados fueron designados recibir propofol, sevoflurano mantenimiento anestesia. Nuestro primer resultado medido escala analógica...