A5059308887- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- Inflammatory Bowel Disease
- Esophageal and GI Pathology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gallbladder and Bile Duct Disorders
- COVID-19 Clinical Research Studies
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Drug-Induced Hepatotoxicity and Protection
- Tracheal and airway disorders
- Eosinophilic Esophagitis
- Celiac Disease Research and Management
- Pancreatic and Hepatic Oncology Research
- Diverticular Disease and Complications
- Infective Endocarditis Diagnosis and Management
- Foreign Body Medical Cases
- Iron Metabolism and Disorders
- Esophageal Cancer Research and Treatment
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Potassium and Related Disorders
- Trace Elements in Health
West Virginia University
2009-2025
West Virginia University Hospitals
2011-2020
Memorial Hospital
2015-2020
Centre For Digestive Diseases
2019
Na Homolce Hospital
2010
We studied clinical outcomes of COVID-19 infection in patients living with HIV (PLH) comparison to non-HIV population.Analysis a multicentre research network TriNETX was performed including more than 10 years age diagnosed COVID-19.Outcomes positive concurrent were compared propensity-matched cohort without (non-PLH).Fifty thousand one hundred and sixty-seven identified (49,763 non-PLH, 404 PLH). PLH likely be men, African-American, obese have hypertension, diabetes, chronic kidney disease...
Background. Organ transplant recipients comprise an immunocompromised and vulnerable cohort. Outcomes of coronavirus disease 2019 (COVID-19) in solid organ (SOT) remain understudied. Methods. We used a multicenter federated research network to compare clinical outcomes COVID-19 patients with SOT propensity--matched cohort without SOT. Results. identified 2307 231 047 nontransplant COVID-19. Transplant were more likely be male individuals, older, have body mass index >30 kg/m 2 , comorbid...
The homologous series of ansa-monocyclopentadienyl amido complexes [(C5H4)SiMe2(N-t-Bu)]M(NMe2)2 (M = Ti (2), Zr (3), Hf (4)) and [(C5Me4)SiMe2(N-t-Bu)]Zr(NMe2)2 (8) are prepared in 70−85% isolated yields by heating the neat 1:1 reaction mixture (C5R4H)SiMe2(N(H)-t-Bu), where R H, Me, M(NMe2)4, at 110−120 °C for 24−48 h under a N2 purge. Whereas reactions 2 with equiv [NEt3H]Cl or HCl produce [(C5H4)SiMe2(N-t-Bu)]TiCl2 (5) [(C5H4)SiMe2Cl]TiCl2(NMe2)(NMe2H) (6), SiMe3Cl toluene provides...
Summary Background Accurate estimates for the risk of COVID‐19 in IBD, and an understanding impact on IBD course incident post‐infectious are needed. Aims To estimate study its IBD. Methods A retrospective propensity score matched cohort utilising multi‐institutional research network TriNetX. patients with without were identified to quantify outcomes disease course. The was compared population not infected during a similar time period. Results Incidence rate ratio lower non‐IBD (0.79, 95%...
Ingestible electronics can transform how patients are diagnosed and treated across many conditions. We developed an ingestible vitals-monitoring pill (VM pill) capable of monitoring vital signs including respiratory rate heart rate. VM performance was evaluated in a swine model opiate overdose human trial sleep laboratory. Sleep studies involve admission to facility, placement multiple skin sensors, overnight observation. hypothesized that the could diagnose clinically significant changes...
ABSTRACT Histoplasmosis capsulatum is a dimorphic fungus commonly considered endemic in the Mississippi and Ohio River Valley regions. can present as asymptomatic immunocompetent patients or disseminated infection immunocompromised patients. Diagnosing histoplasmosis be challenging nonendemic areas, especially presenting primarily with gastrointestinal symptoms. We describe case of an 29-year-old man gastric outlet obstruction caused by region not to .
Iron deficiency anemia is a common complication of ulcerative colitis (UC) that can profoundly impact quality life. Most iron absorption occurs in the duodenum via divalent metal transporter 1 (DMT1)-mediated uptake and ferroportin-1 (FPN1)-mediated export across apical basolateral membranes, respectively. However, colon also contains transporters participate absorption. Studies have shown increased duodenal DMT1 FPN1 patients with UC, but there conflicting evidence about whether expression...
Opioid use is a topic of growing concern among patients with nonalcoholic fatty liver disease (NAFLD). Given safety concerns opioids, proactively identifying subgroups an increased probability opioid may encourage practitioners to recommend alternative therapies for pain, thus reducing the likelihood misuse. This work assessed prevalence and patient characteristics associated in real-world cohort NAFLD.TARGET-NASH, observational study participants at 55 academic community sites United...
Abstract Background and Aim Current guidelines suggest screening at‐risk groups of patients for Barrett's esophagus (BE), a precursor to esophageal cancer. Although BE obstructive sleep apnea (OSA) have common risk factors, including elevated body mass index gastroesophageal reflux disease (GERD), the relationship between these two conditions has not been well established. Methods Retrospectively, all who had undergone polysomnography esophagogastroduodenoscopy at West Virginia University...
Abstract Background One of the most feared complications endoscopic retrograde cholangiopancreatography (ERCP), with an incidence 3.5 to 15%, is post ERCP pancreatitis (PEP). Given role statins in reduction systemic and pancreatic intraluminal inflammation, we hypothesized that use may lower risk PEP. Methods A retrospective cohort study all patients undergoing at West Virginia University during years 2016 2017 was performed. Possible association collected variables PEP assessed Univariate...
Most endoscopies performed in the United States utilize sedation. Anesthesia provides patient comfort and improved procedural quality but adds to complexity of scheduling routine outpatient procedures. We aimed assess return cognitive function after propofol administration patients undergoing endoscopies.Cognitive recovery for endoscopy under monitored anesthesia care was evaluated using EncephalApp. Patients were tested before procedure healthy controls twice, 30 min apart. Results...
The prevalence of osteopenia and osteoporosis in patients with inflammatory bowel disease (IBD) is estimated between 17% 41%, partly due to repeat courses glucocorticoids which enhance the risk for bone disease. Multiple gastroenterological endocrine societies have established guidelines mineral density (BMD) screening IBD, estimates suggesting providers vary their adherence. We aimed improve rate BMD IBD a large academic outpatient practice. Using Plan-Do-Study-Act (PDSA) model, we first...
Intentional ingestion of foreign objects, a form self-injurious behavior, is rarely discussed in the medical literature but often requires extensive evaluation, management, and resources. It can be especially problematic for gastroenterologists, who are consulted removal body. Pica psychiatric diagnosis intentional nonnutritive objects most commonly seen prison inmates those diagnosed with intellectual disability or illness. This case report presents challenging pica, highlighting complexity...
In recent years, wireless capsule endoscopy has become increasingly indicated and utilized in the diagnosis management of small bowel disorders. As such, its most common complication, retention, a more frequently encountered clinical entity. Historically, when medical retention failed, patients have been sent directly to surgery. However, advances enteroscopy demonstrated high success rate safety profile retrieving retained capsules. These approaches appear be viable alternative surgery many...
AimsRecording and analysing impedance fluctuation along the cardiac cycle in right (RV) left ventricles (LV).
Intestinal angioedema is a rare side effect of angiotensin-converting enzyme inhibitors. We present 41-year-old woman with sporadic right lower quadrant abdominal pain and diarrhea multiple computed tomography scans demonstrating enteritis. Suspicion turned to inhibitor use as the cause for patient's illness after an extensive negative evaluation including labs, stool studies, endoscopies, capsule endoscopy. Weeks stopping medication, symptoms improved repeat showed resolution previously...
The diagnosis of a hiatal hernia (HH) can be made by barium oesophagram or upper endoscopy. Data regarding the ability high-resolution manometry (HRM) with oesophageal pressure topography (OPT) to identify HH remains limited. We aim assess diagnostic accuracy automated localisation on compared physician visual interpretation detection HH.Patients (n=181) from West Virginia, Pennsylvania, Maryland, Virginia and Ohio, undergoing HRM OPT 1 January 2015 December 2017 were reviewed. BMIs this...