A5024720272- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pharmacology and Obesity Treatment
- Diabetes Management and Education
- Peroxisome Proliferator-Activated Receptors
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Cardiovascular Function and Risk Factors
- Neuroendocrine Tumor Research Advances
- Chronic Disease Management Strategies
- Cholesterol and Lipid Metabolism
The Ohio State University Wexner Medical Center
2017-2025
The Ohio State University
2015-2024
Columbus Oncology and Hematology Associates
2020-2024
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2024
Methodist Hospital
2009-2015
Cornell University
2009-2015
Houston Methodist
2009-2010
Diabetes Research Center
2009
The University of Texas Southwestern Medical Center
1994-2008
Cardiovascular Research Center
2007
The scavenger receptor, class B, type 1 receptor (SR-BI) mediates the selective transport of lipids from high density lipoprotein to cells. We describe structure and subchromosomal location human <i>SR-BI</i> provide evidence that it is regulated by transcription factor, steroidogenic factor (SF-1).<i>SR-BI</i> resides on chromosome 12q24.2-qter, spans ∼75 kilobase pairs, contains 13 exons. RNA blot analysis tissues reveals an expression pattern similar described previously for rodents with...
Abstract Previous estimates determined prevalence of hypothyroidism (HT) to be 4.6% the US population. This study aimed update HT in United States by retrospective analysis 2 datasets. Data on type (overt or subclinical HT) and treatment were collected from 2009-2010 2011-2012 National Health Nutrition Examination Survey (NHANES) cycles. From Optum administrative claims database, medical pharmacy between January 1, 2012, December 31, 2019. Patients defined as having if, per given year, they...
Abstract Decreased adipose tissue regulatory T cells contribute to insulin resistance in obese mice, however, little is known about the mechanisms regulating numbers humans. Here we obtain from and lean volunteers. Regulatory cell abundance lower vs. visceral subcutaneous associates with reduced sensitivity altered adipocyte metabolic gene expression. decline following high-fat diet induction We see alteration major histocompatibility complex II pathway adipocytes patients after high fat...
A new member of the low density lipoprotein receptor gene family that binds and internalizes very (VLDL) particles was previously cloned characterized from rabbit human.The physiological role this putative VLDL is not known, but its tissue distribution ligand specificity suggest a possible in delivery triglycerides to peripheral tissue.To learn more about potential function receptor, we measured changes mRNA protein various tissues following dietary or hormonal manipulation rats.No...
Abstract In this article we describe the cellular distribution of very low density lipoprotein receptor (VLDLR), a transmembrane protein that is expressed at high concentrations in skeletal muscle, heart, adipose tissue, and brain but only trace amounts liver. Indirect immunofluorescence localization studies were performed murine bovine tissues using rabbit polyclonal anti-human VLDLR antibody. Immunoreactive was detected endothelium capillaries small arterioles not veins or venules ovary,...
Maternal lipoproteins provide nutrients to the fetus via placenta, yolk sac, and uterine membrane plus decidua. To determine transport processes that are responsible for removal of from maternal circulation, we measured clearance rates LDL HDL in vivo, as well tissue distribution expression receptor, glycoprotein 330 (gp330) newly described SR-BI, decidua at mid- late-gestation hamster. In mid-gestation (day 10.5), placenta sac were similar those liver (≈100 μl/h per g) higher than (18 ± 3...
Objective: The objective of this analysis was to compare adherence at 6 months and 12 across levothyroxine formulations for patients with hypothyroidism.Methods: This retrospective utilized insurance claims data from a commercially insured population January 1, 2000 through March 31, 2016. Patients were included if they diagnosed hypothyroidism initiated treatment generic levothyroxine, Levoxyl, Synthroid, Unithroid, or Tirosint. excluded younger than age 18, thyroid cancer, received...
Background: Clinical trials have demonstrated the efficacy and safety of hybrid closed-loop (HCL) systems, yet few studies compared outcomes in real-world setting. Method: This retrospective study analyzed patients from an academic endocrinology practice between January 1, 2018, November 18, 2022. The inclusion criteria were diagnosis code for type I diabetes (T1D), >18 years age, new to any HCL system [Medtronic 670G/770G (MT), Tandem Control IQ (CIQ), or Omnipod 5 (OP5)], availability a...