A5050076657- Diabetes Management and Research
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Education
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Dialysis and Renal Disease Management
- Cardiac Imaging and Diagnostics
- Retinal Diseases and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Retinal Imaging and Analysis
- Erythropoietin and Anemia Treatment
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Heart Rate Variability and Autonomic Control
- Diabetic Foot Ulcer Assessment and Management
- Renal Diseases and Glomerulopathies
Washington University in St. Louis
2016-2025
Group for the Analysis of Development
2023-2025
University of Groningen
2023
Lund University
2023
Woodruff Health Sciences Center
2023
Emory University
2023
The George Institute for Global Health
2023
Novo Nordisk Foundation
2023
University of Toronto
2023
The University of Texas Southwestern Medical Center
2004-2022
Anemia is associated with an increased risk of cardiovascular and renal events among patients type 2 diabetes chronic kidney disease. Although darbepoetin alfa can effectively increase hemoglobin levels, its effect on clinical outcomes in these has not been adequately tested.
<h3>Importance</h3> Previous clinical trials showing the benefit of continuous glucose monitoring (CGM) in management type 1 diabetes predominantly have included adults using insulin pumps, even though majority with administer by injection. <h3>Objective</h3> To determine effectiveness CGM treated injections. <h3>Design, Setting, and Participants</h3> Randomized trial conducted between October 2014 May 2016 at 24 endocrinology practices United States that 158 who were multiple daily...
ATA FROM LARGE OUTCOMEtrials indicate that the level of glycemic control predicts cardiovascular events. 1,2n UK Prospective Diabetes Study (UKPDS), 2 patients with lower initial glycemia had fewer adverse clinical outcomes despite similar progression.Taken together data from National Health and Nutrition Examination Survey IV (NHANES IV), only 37% adults diabetes mellitus (DM) attain recommended levels glycosylated hemoglobin (HbA 1c ), achieving better should further reduce risk 3andomized...
OBJECTIVE Obesity is an important risk factor for type 2 diabetes. Weight loss in patients with diabetes associated improved glycemic control and reduced cardiovascular disease factors, but weight notably difficult to achieve sustain caloric restriction exercise. The purpose of this study was assess the impact treatment orlistat, a pancreatic lipase inhibitor, on loss, control, serum lipid levels obese sulfonylurea medications. RESEARCH DESIGN AND METHODS In multicenter 57-week randomized...
Background: Continuous glucose monitoring (CGM), which studies have shown is beneficial for adults with type 1 diabetes, has not been well-evaluated in those 2 diabetes receiving insulin. Objective: To determine the effectiveness of CGM multiple daily injections Design: Randomized clinical trial. (The protocol also included a cohort parallel trial and subsequent second trial.) (ClinicalTrials.gov: NCT02282397) Setting: 25 endocrinology practices North America. Patients: 158 who had median 17...
Despite substantial evidence of the benefit frequent self-monitoring blood glucose (SMBG) in type 1 diabetes, certain insurers limit number test strips that they will provide. The large database T1D Exchange clinic registry provided an opportunity to evaluate relationship between SMBG measurements per day and HbA1c levels across a wide age range children adults.The analysis included 20,555 participants with diabetes ≥1 year not using continuous monitor (11,641 younger than 18 years 8,914 old...
Objective Depression is a prevalent and chronic condition in diabetes associated with poor glucose regulation compliance treatment. This investigation evaluated the effects of nortriptyline on depression glycemic control to see whether treatable restoring mental health contributes improved medical outcome. Method: Sixty-eight diabetic patients control, 28 whom had active major (DSM-IIIR), completed randomized, placebo-controlled, double-blind trial involving 8 weeks treatment targeted...
<h3>Importance</h3> Continuous glucose monitoring (CGM) has been shown to be beneficial for adults with type 2 diabetes using intensive insulin therapy, but its use in treated basal without prandial not well studied. <h3>Objective</h3> To determine the effectiveness of CGM primary care practices. <h3>Design, Setting, and Participants</h3> This randomized clinical trial was conducted at 15 centers US (enrollment from July 30, 2018, October 2019; follow-up completed 7, 2020) included receiving...
Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering the level allopurinol may slow decrease in glomerular filtration rate (GFR) persons type 1 diabetes and early-to-moderate disease.In a double-blind trial, we randomly assigned participants diabetes, at least 4.5 mg per deciliter, estimated GFR 40.0 to 99.9 ml minute 1.73 m2 body-surface area, evidence disease receive or placebo. The primary outcome was baseline-adjusted GFR, as measured...
<h3>Importance</h3> Continuous glucose monitoring (CGM) provides real-time assessment of levels and may be beneficial in reducing hypoglycemia older adults with type 1 diabetes. <h3>Objective</h3> To determine whether CGM is effective compared standard blood (BGM) <h3>Design, Setting, Participants</h3> Randomized clinical trial conducted at 22 endocrinology practices the United States among 203 least 60 years age <h3>Interventions</h3> Participants were randomly assigned a 1:1 ratio to use...
Currently available semiautomated insulin-delivery systems require individualized insulin regimens for the initialization of therapy and meal doses based on carbohydrate counting routine operation. In contrast, bionic pancreas is initialized only basis body weight, makes all dose decisions delivers autonomously, uses announcements without counting.