A5006554574- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Inflammatory mediators and NSAID effects
- Nutritional Studies and Diet
- Antioxidant Activity and Oxidative Stress
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Venous Thromboembolism Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Marriage and Sexual Relationships
- Acute Myocardial Infarction Research
- Alcohol Consumption and Health Effects
- Obesity, Physical Activity, Diet
- Cancer, Lipids, and Metabolism
- Vitamin C and Antioxidants Research
- Estrogen and related hormone effects
- Cancer Risks and Factors
- Birth, Development, and Health
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
- Fatty Acid Research and Health
- Sodium Intake and Health
- Retinoids in leukemia and cellular processes
- Cardiac Health and Mental Health
- Eicosanoids and Hypertension Pharmacology
Florida Atlantic University
2016-2025
Baylor College of Medicine
2017-2024
University of Michigan
2018-2024
Association for Prevention Teaching and Research
2018-2024
American College of Preventive Medicine
2018-2024
Moscow Institute of Thermal Technology
2023-2024
Seattle University
2023-2024
Washington Center for Equitable Growth
2018-2023
University of Miami
2007-2022
University of Wisconsin–Madison
2022
Inflammation may be important in the pathogenesis of atherothrombosis. We studied whether inflammation increases risk a first thrombotic event and treatment with aspirin decreases risk.
Journal Article REPRODUCIBILITY AND VALIDITY OF A SEMIQUANTITATIVE FOOD FREQUENCY QUESTIONNAIRE Get access WALTER C. WILLETT, WILLETT 1The Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham Women's HospitalBoston, MA2Departments Epidemiology Nutrition, Public HealthBoston, MA Reprint requests to Dr. Walter Willett, Chan-ning 180 Longwood Avenue, Boston, 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar LAURA SAMPSON, SAMPSON...
Observational studies suggest that people who consume more fruits and vegetables containing beta carotene have somewhat lower risks of cancer cardiovascular disease, earlier basic research suggested plausible mechanisms. Because large randomized trials long duration were necessary to test this hypothesis directly, we conducted a trial supplementation.In randomized, double-blind, placebo-controlled (50 mg on alternate days), enrolled 22,071 male physicians, 40 84 years age, in the United...
Background —Interleukin-6 (IL-6) plays a central role in inflammation and tissue injury. However, epidemiological data evaluating the of IL-6 atherogenesis are sparse. Methods Results —In prospective study involving 14 916 apparently healthy men, we measured baseline plasma concentration 202 participants who subsequently developed myocardial infarction (MI) matched for age smoking status did not report vascular disease during 6-year follow-up. Median concentrations at were higher among men...
Interest in the antioxidant vitamin E as a possible protective nutrient against coronary disease has intensified with recognition that oxidized low-density lipoprotein may be involved atherogenesis.
The relation between body weight and overall mortality remains controversial despite considerable investigation.
Insulin-like growth factor–I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and cancer risk, nested case-control study within the Physicians' Health Study was conducted on prospectively collected from 152 cases controls. A strong positive association observed IGF-I risk. Men in highest quartile of had relative risk 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men lowest quartile. This independent baseline...
The effect of postmenopausal estrogen therapy on the risk cardiovascular disease remains controversial. Our 1985 report in Journal, based four years follow-up, suggested that reduced coronary heart disease, but a published simultaneously from Framingham Study was increased. In addition, studies estrogens stroke have yielded conflicting results.
Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on ischemic stroke. There are few similar data women.We randomly assigned 39,876 initially healthy women 45 years age or older to receive 100 mg alternate days placebo and then monitored them for 10 major cardiovascular event (i.e., nonfatal infarction, stroke, death from causes).During follow-up, 477 events were confirmed group, as compared 522 nonsignificant...
The relation between dietary intake of specific types fat, particularly trans unsaturated and the risk coronary disease remains unclear. We therefore studied this in women enrolled Nurses' Health Study.
Background —C-reactive protein (CRP) predicts risk of myocardial infarction (MI) and stroke among apparently healthy men, but in women, virtually no data are available. Methods Results —CRP was measured baseline blood samples from 122 participants the Women’s Health Study who subsequently suffered a first cardiovascular event 244 age- smoking-matched control subjects remained free disease during 3-year follow-up period. Women developed events had higher CRP levels than ( P =0.0001), such...
The effect of adding progestins to estrogen therapy on the risk breast cancer in postmenopausal women is controversial.
We examined the incidence of nonfatal and fatal coronary heart disease in relation to obesity a prospective cohort study 115,886 U.S. women who were 30 55 years age 1976 free diagnosed disease, stroke, cancer. During eight follow-up (775,430 person-years), we identified 605 first events, including 306 myocardial infarctions, 83 deaths due 216 cases confirmed angina pectoris.
Estrogen therapy in postmenopausal women has been associated with a decreased risk of heart disease. There is little information, however, about the effect combined estrogen and progestin on cardiovascular
Postmenopausal hormone therapy has both benefits and hazards, including decreased risks of osteoporosis cardiovascular disease an increased risk breast cancer.
The independent contributions of subfractions high-density lipoprotein (HDL) cholesterol (HDL2 and HDL3) apolipoproteins in predicting the risk myocardial infarction are unclear. Prospective data sparse, but HDL2 is widely believed to be a more important predictor than HDL3.
A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions. Though total 10% lower in treated than control group, this difference not statistically significant chiefly involved diseases stroke infarction. Likewise, there no non-fatal infarction stroke—indeed, disabling strokes were somewhat commoner those allocated aspirin....
To determine the relation of menopause to risk coronary heart disease, we analyzed data on a prospective cohort 121,700 U.S. women 30 55 years old who were followed from 1976 1982. Information menopausal status, type menopause, and other factors was obtained in updated every two by mailing questionnaires. Through 1982, follow-up rate 98.3 percent for mortality 95.4 nonfatal events. After controlled age cigarette smoking, had natural never taken replacement estrogen no appreciable increase as...
Basic research provides plausible mechanisms and observational studies suggest that apparently healthy persons, who self-select for high intakes of vitamin E through diet or supplements, have decreased risks cardiovascular disease cancer. Randomized trials do not generally support benefits E, but there are few long duration among initially persons.To test whether supplementation decreases cancer women.In the Women's Health Study conducted between 1992 2004, 39 876 US women aged at least 45...