A5046793050- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Diabetes Management and Research
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Renal and Vascular Pathologies
- Hormonal Regulation and Hypertension
- Organ Donation and Transplantation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parathyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatitis Pathology and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Potassium and Related Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Advanced Glycation End Products research
- Renal and related cancers
- Lipoproteins and Cardiovascular Health
- Healthcare cost, quality, practices
University of Washington
2016-2025
Providence College
2016-2025
Providence Health & Services
2016-2025
Institute of Translational Health Sciences
2016-2025
Providence Regional Medical Center Everett
2009-2025
Inland Northwest Health Services
2023-2025
Washington State University Spokane
2015-2025
University of Rochester
2023-2025
Golisano Children's Hospital
2021-2025
University of Cape Town
2025
Diabetic kidney disease develops in approximately 40% of patients who are diabetic and is the leading cause CKD worldwide. Although ESRD may be most recognizable consequence disease, majority actually die from cardiovascular diseases infections before needing replacement therapy. The natural history includes glomerular hyperfiltration, progressive albuminuria, declining GFR, ultimately, ESRD. Metabolic changes associated with diabetes lead to hypertrophy, glomerulosclerosis,...
The effects of empagliflozin in patients with chronic kidney disease who are at risk for progression not well understood. EMPA-KIDNEY trial was designed to assess the treatment a broad range such patients.
Type 2 diabetes associates with increased risk of mortality, but how kidney disease contributes to this mortality among individuals type is not completely understood. Here, we examined 10-year cumulative by and status for 15,046 participants in the Third National Health Nutrition Examination Survey (NHANES III) linking baseline data from NHANES III Death Index. Kidney disease, defined as urinary albumin/creatinine ratio ≥30 mg/g and/or estimated GFR ≤60 ml/min per 1.73 m2, was present 9.4%...
The worldwide epidemic of metabolic syndrome correlates with an elevation in serum uric acid as well a marked increase total fructose intake (in the form table sugar and high-fructose corn syrup). Fructose raises acid, latter inhibits nitric oxide bioavailability. Because insulin requires to stimulate glucose uptake, we hypothesized that fructose-induced hyperuricemia may have pathogenic role syndrome. Four sets experiments were performed. First, pair-feeding studies showed fructose, not...
The incidence and prevalence of diabetes mellitus have grown significantly throughout the world, due primarily to increase in type 2 diabetes. This overall number people with has had a major impact on development diabetic kidney disease (DKD), one most frequent complications both types DKD is leading cause end-stage renal (ESRD), accounting for approximately 50% cases developed world. Although rates ESRD attributable recently stabilized, these continue rise high-risk groups such as...
The Kidney Disease: Improving Global Outcomes (KDIGO) 2020 Clinical Practice Guideline for Diabetes Management in Chronic Disease (CKD) represents the first KDIGO guideline on this subject. scope includes topics such as comprehensive care, glycemic monitoring and targets, lifestyle antihyperglycemic interventions, approaches to self-management optimal models of care. goal is generate a useful resource clinicians patients by providing actionable recommendations with infographics based...
Atherosclerotic renal-artery stenosis is a common problem in the elderly. Despite two randomized trials that did not show benefit of stenting with respect to kidney function, usefulness for prevention major adverse renal and cardiovascular events uncertain.We randomly assigned 947 participants who had atherosclerotic either systolic hypertension while taking or more antihypertensive drugs chronic disease medical therapy plus alone. Participants were followed occurrence (a composite end point...
<h3>Importance</h3> Diabetic kidney disease is the leading cause of chronic and end-stage in United States worldwide. Changes demographics treatments may affect prevalence clinical manifestations diabetic disease. <h3>Objective</h3> To characterize among US adults with diabetes over time. <h3>Design, Setting, Participants</h3> Serial cross-sectional studies aged 20 years or older mellitus participating National Health Nutrition Examination Surveys from 1988 through 2014. <h3>Exposures</h3>...
The Kidney Disease: Improving Global Outcomes (KDIGO) 2022 Clinical Practice Guideline for Diabetes Management in Chronic Disease (CKD) represents a focused update of the KDIGO 2020 guideline on topic. targets broad audience clinicians treating diabetes and CKD. Topic areas which recommendations are updated include: Chapter 1: Comprehensive care patients with CKD 4: Glucose-lowering therapies type 2 (T2D) Previous chapters Glycemic monitoring (Chapter 2), Lifestyle interventions 3),...
Patients with type 2 diabetes and chronic kidney disease are at high risk for failure, cardiovascular events, death. Whether treatment semaglutide would mitigate these risks is unknown.
Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering the level allopurinol may slow decrease in glomerular filtration rate (GFR) persons type 1 diabetes and early-to-moderate disease.In a double-blind trial, we randomly assigned participants diabetes, at least 4.5 mg per deciliter, estimated GFR 40.0 to 99.9 ml minute 1.73 m2 body-surface area, evidence disease receive or placebo. The primary outcome was baseline-adjusted GFR, as measured...