A5012560465- Ovarian function and disorders
- Stress Responses and Cortisol
- Reproductive Biology and Fertility
- Menstrual Health and Disorders
- Hypothalamic control of reproductive hormones
- Menopause: Health Impacts and Treatments
- Neuroendocrine regulation and behavior
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Assisted Reproductive Technology and Twin Pregnancy
- Circadian rhythm and melatonin
- Growth Hormone and Insulin-like Growth Factors
- Reproductive System and Pregnancy
- Reproductive Health and Technologies
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Regulation of Appetite and Obesity
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related cognitive impairment studies
- Biochemical effects in animals
- Cancer Risks and Factors
- Sex and Gender in Healthcare
- Ovarian cancer diagnosis and treatment
- Cardiovascular Issues in Pregnancy
- Reproductive Health and Contraception
University at Buffalo, State University of New York
2020-2025
Buffalo State University
2024
Jacobs Institute
2023
Kaleida Health
2023
Wake Forest University
2011-2021
University of Utah
2018-2021
Atrium Health Wake Forest Baptist
2008-2019
Colorado Center for Reproductive Medicine
2019
University of Pittsburgh
1999-2015
University of Southern California
2015
The goal of the study was to compare cardiovascular heart disease risk factors in women with polycystic ovary syndrome (PCOS) and matched control subjects. Women PCOS have factors, including anovulation, hyperandrogenism, insulin resistance, that suggest a male coronary risk-factor profile. A total 206 were recruited by using records from large reproductive endocrinology practice. clinical diagnosis made if there history chronic anovulation association either evidence androgen excess...
The American Society for Reproductive Medicine, the European of Endocrinology, and Pediatric Endocrine Society. This guideline was funded by To formulate clinical practice guidelines diagnosis treatment functional hypothalamic amenorrhea (FHA). participants include an Society–appointed task force eight experts, a methodologist, medical writer. evidence-based developed using Grading Recommendations, Assessment, Development, Evaluation approach to describe strength recommendations quality...
To further elucidate the neuroendocrine regulation of anterior pituitary function in women with functional hypothalamic amenorrhea (FHA), we measured serum LH, FSH, cortisol, GH, PRL, TSH concentrations simultaneously at frequent intervals for 24 h 10 FHA and normal early follicular phase (NC). Using same data, separately analyzed cortisol-PRL responses to meals these women. In addition, simultaneous administration GnRH, CRH, GHRH, TRH were assessed 6 The 24-h secretory pattern each hormone...
Abstract The purpose of this study was to determine whether cognitive function changes over time in women with breast cancer who received adjuvant therapy as compared no therapy. Three groups ( n =46) were studied; 1 and 2 consisted stage I or II cancer. Group chemotherapy group plus tamoxifen. 3 ductal carcinoma situ Cognitive evaluated at three timepoints. Time occurred after surgery before initiation 2. for post‐surgery. within week the conclusion a comparable 3. year Women tamoxifen...
This study explored the relationship between circadian performance rhythms and in rectal temperature, plasma cortisol, melatonin, subjective alertness well-being. Seventeen healthy young adults were studied under 36 h of 'unmasking' conditions (constant wakeful bedrest, temporal isolation, homogenized 'meals') during which temperatures measured every minute, cortisol melatonin 20 min. Hourly ratings global vigour (alertness) affect (well-being) obtained followed by one two batteries. On...
✓ The proper treatment of multiple and incidental aneurysms remains controversial because the long-term result different modes management is unclear. This report evaluates outcome (follow-up period averaged 7.7 years) in 182 patients with who suffered a subarachnoid hemorrhage (SAH) to document incidence late bleeding. Of patients, 132 were treated by bed rest 50 surgery (craniotomy) directed at only ruptured aneurysm. Seventy alive after 6 months. Twenty-one these conservatively (30%)...
Female obesity is linked to abnormal menstrual cycles, infertility, reproductive wastage, and deficient LH, FSH, progesterone secretion.To elucidate the defects associated with obesity, we sampled 18 eumenorrheic (nonpolycystic ovary syndrome) women a mean +/- sem body mass index of 48.6 1.4 kg/m2 daily, first morning voided urine collections, seven whom also had early follicular phase 12-h, every 10-min blood sampling assess LH pulses. Daily hormones were compared 11 eumenorrheic,...
Background: Technical hurdles limit the characterization of key hormonal rhythms. Frequent sampling increases detection changes in magnitude or circadian and ultradian patterns, but limits feasibility for clinical research settings. These caveats are particularly pertinent cortisol, a hormone that displays prominent rhythm whose is tightly regulated absence biobehavioural challenge. Ideally, one would like to obtain samples non-invasively from matrix interest at frequent intervals. While...
Plasma melatonin levels were determined by a sensitive RIA at 30 min intervals for 24h in 7 women with functional hypothalamic amenorrhea (HA) and age season matched normal cycling the early follicular phase (NC). While daytime concentrations nondetectable both groups, integrated nocturnal 3-fold greater HA (244 ± 58 (se) vs 74 32 pmol-min/L×103, p<0.005). This increase was due to an elevated peak amplitude (p<0.01) extended duration (p<0.05). The latter mostly significant delay offset time...
In Brief Objective: Hormones have been implicated as modulators of cognitive functioning. For instance, results our previous work in women with breast cancer showed that impairment was more severe and involved memory domains those who received adjuvant tamoxifen therapy compared chemotherapy alone or no therapy. Recently aromatase inhibitors such anastrozole used lieu for the treatment postmenopausal hormone receptor-positive, early-stage cancer. Plasma estrogen levels are significantly...
Experimental traumatic brain injury (TBI) studies report the neuroprotective effects of female sex steroids on multiple mechanisms injury, with clinical assumption that women have hormonally mediated neuroprotection because endogenous presence these hormones. Other literature indicates testosterone may exacerbate injury. Further, stress hormone abnormalities accompany critical illness both amplify or blunt steroid levels. To better understand role exposure in mediating TBI, we 1)...
The role of energy imbalance versus psychosocial stress in the pathogenesis female reproductive dysfunction characterized by anovulation and amenorrhea remains controversial. In women, functional hypothalamic can develop absence significant weight loss, excessive exercise, or profound disruption. We posited, therefore, that commonplace, seemingly minor stressors alone would have minimal impact upon function might interact synergistically such combinations cause a greater impairment axis than...
Rupture of the fetal membranes is a common harbinger imminent labor and delivery. Telomere shortening surrogate for oxidative stress (OS) senescence. Fetal leukocyte placental membrane DNA telomere lengths were evaluated to determine their association with preterm prelabor rupture (pPROM) or spontaneous births intact (PTB), compared term birth.Telomere quantified in cord blood leukocytes (n = 133) from three major groups: 1) pPROM 28), 2) PTB 69) 3) uncomplicated full (controls, n 35), using...
BACKGROUND The purpose of this study was to examine and compare the effects first 18 months anastrozole therapy on cognitive function in women with breast cancer. METHODS This large, longitudinal cohort composed postmenopausal early‐stage cancer who received chemotherapy plus (n = 114) or alone 173) a control group 110). Cognitive assessed before systemic 6, 12, after initiation at comparable time points controls. RESULTS chemotherapy‐anastrozole anastrozole‐alone groups had poorer executive...
Background Previous studies have reported an association between the timing of menarche and cardiovascular disease ( CVD ). However, emerging not examined in relation to role estrogen over a lifetime major adverse cardiac events MACE Methods Results A total 648 women without surgical menopause undergoing coronary angiography for suspected ischemia WISE (Women's Ischemia Syndrome Evaluation) study were evaluated at baseline followed 6 years (median) assess outcomes. was defined as first...
During the follicular phase of menstrual cycle, FSH stimulates growth, granulosa cell aromatase activity, induction LH receptors on membrane, and estradiol secretion. As a result negative feedback pituitary, serum concentrations decline. Despite fall in concentrations, maturing follicle continues to develop preovulatory stage. In prospective randomized trial, we tested hypothesis that key mechanism by which dominant face decreasing concentration is acquiring responsiveness. 24 women,...