A5064264687- Treatment of Major Depression
- Sleep and related disorders
- Sleep and Wakefulness Research
- Mental Health Treatment and Access
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Grief, Bereavement, and Mental Health
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Health disparities and outcomes
- Cardiac Health and Mental Health
- Bipolar Disorder and Treatment
- Family Caregiving in Mental Illness
- Migration, Health and Trauma
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Aging and Gerontology Research
- Tryptophan and brain disorders
- Palliative Care and End-of-Life Issues
- Suicide and Self-Harm Studies
- Electroconvulsive Therapy Studies
- Circadian rhythm and melatonin
- Health Systems, Economic Evaluations, Quality of Life
- Sleep and Work-Related Fatigue
University of Pittsburgh
2016-2025
University of Pittsburgh Medical Center
2015-2024
UPMC Health System
1999-2024
University of Toronto
2009-2024
American Journal Experts (United States)
2024
Pittsburg State University
1992-2023
MaineHealth
2023
Tufts University
2011-2023
Western Pennsylvania Hospital
1981-2022
Bridge University
2001-2022
Complicated grief is a debilitating disorder associated with important negative health consequences, but the results of existing treatments for it have been disappointing.To compare efficacy novel approach, complicated treatment, standard psychotherapy (interpersonal psychotherapy).Two-cell, prospective, randomized controlled clinical trial, stratified by manner death loved one and treatment site.A university-based psychiatric research clinic as well satellite in low-income African American...
Suicide rates are highest in late life; the majority of older adults who die by suicide have seen a primary care physician preceding months. Depression is strongest risk factor for late-life and suicide's precursor, suicidal ideation.To determine effect intervention on ideation depression patients.Randomized controlled trial known as PROSPECT (Prevention Primary Care Elderly: Collaborative Trial) with patient recruitment from 20 practices New York City, Philadelphia, Pittsburgh regions, May...
Subjective sleep quality deteriorates with aging, but the extent to which this is a product of age itself, as opposed medical or psychiatric problems associated has not been carefully studied. To investigate issue, we examined subjective 44 healthy subjects between ages 20 and 30 (23 men, 12 women) using Pittsburgh Sleep Quality Index (PSQI). All underwent rigorous evaluations verify that they were in excellent physical psychological health. Significant effects noted for global PSQI score...
This study sought to determine whether a set of symptoms interpreted as complicated grief could be identified and distinguished from bereavement-related depression the presence would predict enduring functional impairments.Data were derived group 82 recently widowed elderly individuals recruited for an investigation physiological changes in bereaved persons. Baseline data collected 3-6 months after deaths subjects' spouses, follow-up 56 subjects 18 baseline assessments. Candidate items...
The aim of this study was to confirm and extend the authors' previous work indicating that symptoms traumatic grief are predictors future physical mental health outcomes.The group consisted 150 widows widowers interviewed at time their spouse's hospital admission 6-week 6-, 13-, 25- month follow-ups. Traumatic measured with a modified version Grief Measurement Scale. Mental outcomes were assessed by self-report interviewer evaluation. Survival analysis linear logistic regressions used...
ContextElderly patients with major depression are at high risk for recurrence, increased mortality, and chronic disability.ObjectiveTo determine the efficacy of maintenance nortriptyline hydrochloride interpersonal psychotherapy (IPT) in preventing recurrence depressive episodes older than 59 years.DesignA 2×2 randomized, double-blind, placebo-controlled clinical trial, stratified by therapist.SettingUniversity-based psychiatric research clinic.PatientsOf a total 187 recurrent nonpsychotic...
<h3>Context</h3> Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome. <h3>Objectives</h3> To determine the characteristics determinants of neuropsychological functioning LLD. <h3>Design</h3> Cross-sectional study groups LLD patients control subjects. <h3>Setting</h3> Outpatient, university-based research clinic. <h3>Participants</h3> One hundred without dementia 60 years older who...
Objective Evidence concerning whether sleep disturbances in older adults predict mortality is mixed. However, data are limited to self-reported problems and may be confounded with other comorbidities. We examined electroencephalographic (EEG) parameters predicted survival time independently of known predictors all-cause mortality. Methods A total 185 healthy adults, primarily their 60s through 80s, no history mental illness, complaints, or current cognitive impairment, were enrolled one...
Increasingly, there is a need in both research and clinical practice to document quantify sleep waking behaviors comprehensive manner. The Pittsburgh Sleep Diary (PghSD) an instrument with separate components be completed at bedtime waketime. Bedtime relate the events of day preceding sleep, waketime period just completed. Two-week PghSD data presented from 234 different subjects, comprising 96 healthy young middle-aged controls, 37 older men, 44 women, 29 adult controls 28 disorders...
There is a strong association between late-life depression, cognitive impairment, cerebrovascular disease, and poor outcomes, including progressive dementia, especially Alzheimer's disease. While neuroimaging evidence suggests that disease plays prominent role, it seems depression alone may also confer substantial risk for developing The relationships the changes, other structural abnormalities, specific forms of dysfunction, increased among those with have been difficult to reconcile....
<h3>Background</h3> Chronic insomnia is a common health problem with substantial consequences in older adults. Cognitive behavioral treatments are efficacious but not widely available. The aim of this study was to test the efficacy brief treatment for (BBTI) vs an information control (IC) condition. <h3>Methods</h3> A total 79 adults (mean age, 71.7 years; 54 women [70%]) chronic and comorbidities were recruited from community 1 primary care clinic. Participants randomly assigned either...
Although psychotherapy and antidepressant medication are efficacious in the treatment of depressive anxiety disorders, it is not known whether they equally for all types antidepressants each disorder. We conducted a meta-analysis studies which were directly compared disorders. Systematic searches bibliographical databases resulted 67 randomized trials, including 5,993 patients that met inclusion criteria, 40 focusing on disorders 27 The overall effect size indicating difference between...
Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of disability, and death.