Ryan Bailey
A5086879303- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Diabetes Management and Education
- Heart Rate Variability and Autonomic Control
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Syncope and Autonomic Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Musculoskeletal synovial abnormalities and treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ethics in Clinical Research
- Genetic factors in colorectal cancer
- Wireless Body Area Networks
- Bone Tumor Diagnosis and Treatments
- Global Cancer Incidence and Screening
- Vitamin D Research Studies
- Microbial Metabolic Engineering and Bioproduction
- Corneal Surgery and Treatments
- Renal Diseases and Glomerulopathies
- Inhalation and Respiratory Drug Delivery
- Ovarian function and disorders
- Ocular Surface and Contact Lens
- Viral-associated cancers and disorders
- Natural Antidiabetic Agents Studies
Jaeb Center for Health Research
2020-2025
University of Iowa Hospitals and Clinics
2024
The University of Texas Health Science Center at Houston
2024
Florida College
2023
University of South Florida
2018-2023
University of St Andrews
2021
Queen Mary University of London
2021
Vanderbilt University Medical Center
2021
Health Research Foundation
2020
University of Tampa
2020
<h3>Importance</h3> Continuous glucose monitoring (CGM) has been shown to be beneficial for adults with type 2 diabetes using intensive insulin therapy, but its use in treated basal without prandial not well studied. <h3>Objective</h3> To determine the effectiveness of CGM primary care practices. <h3>Design, Setting, and Participants</h3> This randomized clinical trial was conducted at 15 centers US (enrollment from July 30, 2018, October 2019; follow-up completed 7, 2020) included receiving...
Importance In preclinical studies, thioredoxin-interacting protein overexpression induces pancreatic beta cell apoptosis and is involved in glucotoxicity-induced death. Calcium channel blockers reduce these effects may be beneficial to preservation type 1 diabetes. Objective To determine the effect of verapamil on function children adolescents with newly diagnosed Design, Setting, Participants This double-blind, randomized clinical trial including aged 7 17 years diabetes who weighed 30 kg...
Whether improved glucose control with hybrid closed-loop therapy can preserve C-peptide secretion as compared standard insulin in persons new-onset type 1 diabetes is unclear.In a multicenter, open-label, parallel-group, randomized trial, we assigned youths 10.0 to 16.9 years of age within 21 days after diagnosis receive or (control) for 24 months. The primary end point was the area under curve (AUC) plasma level (after mixed-meal tolerance test) at 12 months diagnosis. analysis performed on...
Importance Near normalization of glucose levels instituted immediately after diagnosis type 1 diabetes has been postulated to preserve pancreatic beta cell function by reducing glucotoxicity. Previous studies have hampered an inability achieve tight glycemic goals. Objective To determine the effectiveness intensive management near on preservation in youth with newly diagnosed diabetes. Design, Setting, and Participants This randomized, double-blind, clinical trial was conducted at 6 centers...
Objective: To evaluate the safety and effectiveness of Loop Do-It-Yourself automated insulin delivery system. Research Design Methods: A prospective real-world observational study was conducted, which included 558 adults children (age range 1-71 years, mean HbA1c 6.8% ± 1.0%) who initiated either on their own or with community-developed resources provided data for 6 months. Results: Mean time-in-range 70-180 mg/dL (TIR) increased from 67% 16% at baseline (before starting Loop) to 73% 13%...
OBJECTIVE To explore the effect of discontinuing continuous glucose monitoring (CGM) after 8 months CGM use in adults with type 2 diabetes treated basal without bolus insulin. RESEARCH DESIGN AND METHODS This multicenter trial had an initial randomization to either real-time or blood (BGM) for followed by 6 which BGM group continued (n = 57) and was randomly reassigned continue 53) discontinue resumption 53). RESULTS In that discontinued CGM, mean time range (TIR) 70–180 mg/dL, improved from...
This article reports on the lived experience of Medtronic advanced hybrid closed-loop (AHCL) in comparison to first generation (HCL) a randomized, open-label, two-period crossover trial. Patient-reported outcome (PROs) measures were administered before randomization and at end each study period 113 adolescents young adults with type 1 diabetes. Glucose monitoring satisfaction subscales for emotional burden behavioral improved significantly (P < 0.01) over time use AHCL versus HCL co-occurred...
Objective: To evaluate the effectiveness and safety of real-time continuous glucose monitoring (CGM) in adults 65 years old older with type 2 diabetes (T2D) using basal without bolus insulin. Research Design Methods: Using data from MOBILE randomized trial comparing CGM versus blood meter (BGM) for T2D treated insulin, treatment effect participants ≥65 (range: 65-79 years, N = 42) was compared <65 33-64 133). Results: For old, mean change hemoglobin A1c (HbA1c) -1.08% group -0.38% BGM...
Aim: The impact of weight gain on insulin dosage and glycemic control in adults with type 1 diabetes (T1D) aged 25 years older was investigated the T1D Exchange Registry participants. Methods: Participants were categorized into four groups based their change from registry enrollment to year 5: stable (−5 <5 lb), gained 5 <10 lb, 10 <20 or ≥20 lb. Those who lost >5 lb excluded. primary outcomes glucose control, as measured by glycosylated hemoglobin (HbA1c), total daily dose (TDD) at 5....
To evaluate the safety and explore efficacy of use ultra-rapid lispro (URLi, Lyumjev) insulin in Tandem t:slim X2 pump with Control-IQ 1.5 technology children, teenagers, adults living type 1 diabetes (T1D).
We evaluated the effect of long-term intensive metabolic control with hybrid closed-loop (CL) on residual C-peptide secretion and glucose compared standard insulin therapy in youth type 1 diabetes over 48 months.
Abstract Context Cardiovascular disease (CVD) is a major cause of mortality in adults with type 1 diabetes. Objective We prospectively evaluated CVD risk factors large, contemporary cohort diabetes living the United States. Design Observational study and over median 5.3 years. Setting The T1D Exchange clinic network. Patients Adults (age ≥ 18 years) without known diagnosed before or at enrollment. Main Outcome Measure Associations between incident were assessed by multivariable logistic...
Background: Postmeal hyperglycemia is difficult to avoid even with automated insulin delivery (AID) due the delayed effect of subcutaneously administered rapid-acting analogs. Inhaled technosphere (TI, Afrezza®) has a more rapid onset action potential reduce postmeal glucose rise. We evaluated effects regimen TI and degludec over 30 weeks. Methods: In total, 123 adults type 1 diabetes (T1D) participated in 17-week multicenter randomized controlled trial comparing plus versus usual care,...
This study evaluated the effects of ultra-rapid lispro (URLi) insulin versus on postprandial glucose excursions in 176 individuals with type 1 diabetes using Control-IQ+ technology. Postprandial glycemia differed most between URLi and at 60 min (mean 166 ± 69 mg/dL vs. 178 70 mg/dL; adjusted mean difference [AMD] = -11 P < 0.001). The had slightly lower excursion compared (AMD -4 0.001), but differences treatments were larger following breakfast -9 mg/dL) lunch -2 dinner mg/dL). Participants...
Objective: To determine if type 2 diabetes patients using basal insulin without prandial with worse glycemic control at baseline would have the greatest benefit from real-time continuous glucose monitoring (CGM). Methods: We conducted a post hoc analysis of MOBILE Study, multicenter trial examining impact CGM versus self-monitoring blood meter (BGM) in treated insulin. Participants were divided into subgroups based on hemoglobin A1c (HbA1c) and time-in-range 70-180 mg/dL (TIR). Change TIR...
Background: We recently reported that use of an "advanced" hybrid closed-loop system reduced hyperglycemia without increasing hypoglycemia compared to a first-generation system. The aim this analysis was evaluate whether improved performance specifically related better mealtime glycemic control. Methods: conducted secondary postprandial control in open-label, multinational, randomized crossover trial 112 participants with type 1 diabetes, aged 14-29, the Medtronic MiniMed™ 670G (670G) versus...
We compared the glucose management indicator (GMI) calculated using 14 days of continuous monitor (CGM) data with GMI <14 days. Analysis included 581 individuals type 1 diabetes or 2 from five clinical trials. The correlation between 14- and 7-day was 0.95 versus 10, 5, 3 0.98, 0.91, 0.86, respectively. percentages values within 0.3% 14-day were 98% 10-day GMI, 87% 77% 5-day 60% 3-day GMI. Minimal differences observed computed 7 Although 10-14 CGM are preferred for computing most patients a...
Brief summary: In this double-blind, randomized clinical trial conducted in 6 US centres, 88 children and adolescents (aged 717 years) with newly diagnosed type 1 diabetes (T1D) were to either once-daily oral verapamil or placebo, within month from diagnosis. Treatment led better stimulated C-peptide secretion at 52 weeks post-diagnosis, levels 30% higher compared placebo.
Background: Loop is an open-source automated insulin dosing system that allows users unrivaled control over settings affect future glucose prediction. Thousands use Loop, but little known about those who discontinue. Methods: In a large observational study, 874 participants completed surveys and provided glycemic data, 46 (5.3%) of self-identified as discontinuing during the observation window, 45 discontinued survey, 22 19 participated in semistructured interviews their discontinuation....
OBJECTIVE We evaluated the performance of iLet bionic pancreas (BP) in non-Hispanic White individuals (here referred to as “Whites”) and Black, Hispanic, other collectively “Minorities”). RESEARCH DESIGN AND METHODS A multicenter, randomized controlled trial glycemic management with BP versus standard care (SC) 161 adult 165 pediatric participants type 1 diabetes over 13 weeks. RESULTS In Whites (n = 240), mean baseline-adjusted difference 13-week HbA1c between SC groups was −0.45% (95% CI...
To report the safety and side effects associated with taking verapamil for beta-cell preservation in children newly-diagnosed T1D. Eighty-eight participants aged 8.5 to 17.9 years weighing ≥ 30 kg were randomly assigned (N = 47) or placebo 41) within 31 days of T1D diagnosis followed 12 months from diagnosis, main CLVer study. Drug dosing was weight-based incremental increases full dosage. Side effect monitoring included serial measurements pulse, blood pressure, liver enzymes,...