A5038772102- American Constitutional Law and Politics
- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Judicial and Constitutional Studies
- International Law and Human Rights
- Glioma Diagnosis and Treatment
- Legal and Constitutional Studies
- Multicultural Socio-Legal Studies
- Political Philosophy and Ethics
- Political Systems and Governance
- Legal Systems and Judicial Processes
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Socioeconomic Development in Asia
- Sulfur Compounds in Biology
- Pain Mechanisms and Treatments
- Sexual Differentiation and Disorders
- Law in Society and Culture
- Disaster Management and Resilience
- Hemoglobinopathies and Related Disorders
- Botulinum Toxin and Related Neurological Disorders
- Chromatin Remodeling and Cancer
- Mast cells and histamine
- Legal Language and Interpretation
Children's Mercy Hospital
1999-2024
University of Missouri–Kansas City
1999-2024
Virginia Tech
1998-2019
Vancouver General Hospital
2007-2010
University of British Columbia
2003-2010
Fordham University
1999
University of Kansas
1987-1997
University of Kansas Medical Center
1986
Journal Article Sovereign Virtue: The Theory and Practice of Equality Get access by Ronald Dworkin. Cambridge, MA, Harvard University Press, 2000. 511 pp. $35.00. Wayne D. Moore Virginia Polytechnic Institute State Search for other works this author on: Oxford Academic Google Scholar Political Science Quarterly, Volume 116, Issue 1, Spring 2001, Pages 158–160, https://doi.org/10.2307/2657842 Published: 15 February 2013
Type 1 diabetes is a chronic autoimmune disease that leads to destruction of insulin-producing beta cells and dependence on exogenous insulin for survival. Some interventions have delayed the loss production in patients with type diabetes, but might affect clinical progression before diagnosis are needed.We conducted phase 2, randomized, placebo-controlled, double-blind trial teplizumab (an Fc receptor-nonbinding anti-CD3 monoclonal antibody) involving relatives who did not were at high risk...
Teplizumab treatment of nondiabetic relatives at high risk for T1D induces partially exhausted CD8 + T cells and improves beta cell function.
Importance In preclinical studies, thioredoxin-interacting protein overexpression induces pancreatic beta cell apoptosis and is involved in glucotoxicity-induced death. Calcium channel blockers reduce these effects may be beneficial to preservation type 1 diabetes. Objective To determine the effect of verapamil on function children adolescents with newly diagnosed Design, Setting, Participants This double-blind, randomized clinical trial including aged 7 17 years diabetes who weighed 30 kg...
Importance Near normalization of glucose levels instituted immediately after diagnosis type 1 diabetes has been postulated to preserve pancreatic beta cell function by reducing glucotoxicity. Previous studies have hampered an inability achieve tight glycemic goals. Objective To determine the effectiveness intensive management near on preservation in youth with newly diagnosed diabetes. Design, Setting, and Participants This randomized, double-blind, clinical trial was conducted at 6 centers...
A three-arm, randomized, double-masked, placebo-controlled phase 2b trial performed by the Type 1 Diabetes TrialNet Study Group previously demonstrated that low-dose anti-thymocyte globulin (ATG) (2.5 mg/kg) preserved β-cell function and reduced HbA1c for year in new-onset type diabetes. Subjects (N = 89) were randomized to 1) ATG pegylated granulocyte colony-stimulating factor (GCSF), 2) alone, or 3) placebo. Herein, we report 2-year area under curve (AUC) C-peptide HbA1c, prespecified...
The authors have shown previously that intracellular glutathione (GSH) plays an important role in the regulation of human immunodeficiency virus (HIV) transcription and replication vitro, through modulation signal transduction by inflammatory cytokines. Moreover, GSH levels are known to regulate T-lymphocyte function. In multiparameter FACS studies presented here, we show relative CD4+ CD8+ T cells from HIV+ individuals significantly lower than corresponding subsets uninfected controls....
Epithelioid and rhabdoid glioblastomas are rare entities that share some overlapping morphologic features, but remain poorly characterized at the immunohistochemical genetic level. We report 10 examples: 8 epithelioid (E-GBMs) 2 GBMs (R-GBMs). E-GBMs tended to be superficially located, circumscribed, supratentorial tumors composed of monotonous, discohesive sheets small rounded cells mimicked metastatic malignant melanoma. R-GBMs showed tumor with classic features arising as a subpopulation...
P53 expression and increased MIB-1 proliferation index have been shown to correlate with invasive behavior in pituitary adenomas. The purpose of this study was determine whether these indices could be used predict a higher likelihood recurrence clinically nonfunctional adenomas thus guide adjuvant therapy.Fifty-one were selected from the database at Vancouver Hospital Health Sciences Center between years 1990-1998. Included 32 nonrecurrent 19 recurrent adenomas.The mean initial labelling for...
Journal Article The People Themselves: Popular Constitutionalism and Judicial Review Get access Kramer Larry D.. Review. New York: Oxford University Press, 2004. xii, 363 pp. $29.95 (cloth); $17.95 (paper). Wayne D. Moore Virginia Tech Search for other works by this author on: Academic Google Scholar American of Legal History, Volume 48, Issue 1, January 2006, Pages 100–102, https://doi.org/10.2307/25434776 Published: 01 2006
OBJECTIVE Mixed-meal tolerance test–stimulated area under the curve (AUC) C-peptide at 12–24 months represents primary end point for nearly all intervention trials seeking to preserve β-cell function in recent-onset type 1 diabetes. We hypothesized that participant benefit might be detected earlier and predict outcomes 12 posttherapy. Such findings would support shorter establish initial efficacy. RESEARCH DESIGN AND METHODS examined data from six Type Diabetes TrialNet immunotherapy...
OBJECTIVE To assess the progression of type 1 diabetes using time to peak glucose or C-peptide during oral tolerance tests (OGTTs) in autoantibody-positive relatives people with diabetes. RESEARCH DESIGN AND METHODS We examined 2-h OGTTs participants Diabetes Prevention Trial Type (DPT-1) and TrialNet Pathway (PTP) studies. included 706 DPT-1 (mean ± SD age, 13.84 9.53 years; BMI Z-score, 0.33 1.07; 56.1% male) 3,720 PTP (age, 16.01 12.33 0.66 1.3; 49.7% male). Log-rank testing Cox...
Journal Article Covenant and Constitutionalism: The Great Frontier the Matrix of Federal Democracy Get access Elazar Daniel J., Democracy. (The Tradition in Politics, vol. 3). New Brunswick, N.J.: Transaction Publishers, 1998. xii, 287 pp. $44.95. Wayne D. Moore Virginia Polytechnic Institute State University Search for other works by this author on: Oxford Academic Google Scholar American Legal History, Volume 42, Issue 3, July 1998, Pages 316–317, https://doi.org/10.2307/846195 Published: 01 1998
This work examines the relation between concept of people and design American constitution. It asks such questions as: Who is included among people?; How are politically configured?; may act?; how do relate to government structures? The author considers historical material from antebellum period, as opinions US Supreme Court justices in Dred Scott case, different perspectives writings speeches Frederick Douglass. Influential thinking founding period covered; there also an examination issues...
Journal Article Final Freedom: The Civil War, the Abolition of Slavery, and Thirteenth Amendment Get access Vorenberg Michael, Amendment. Cambridge: Cambridge University Press, 2001. xviii, 305 pp. $29.95. Wayne D. Moore Virginia Polytechnic Institute State Search for other works by this author on: Oxford Academic Google Scholar American Legal History, Volume 45, Issue 2, April 2001, Pages 228–230, https://doi.org/10.2307/3185376 Published: 01 2001
Objective. To further evaluate glycemic outcomes during the observational extension phase of Continuous Glucose Monitoring (CGM) Intervention for Teens and Young Adults randomized clinical trial (RCT). Subjects Methods. Following a 26-week RCT comparing CGM with blood glucose monitoring (BGM) in 153 adolescents young adults aged 14 to <25 years old suboptimally controlled type 1 diabetes, 70 (89%) participants BGM group initiated use (referred as BGM–CGM cohort), (95%) continued (CGM–CGM...
<p dir="ltr">Objective: Mixed meal tolerance test stimulated area under the curve (AUC) C-peptide at 12 to 24 months represents primary endpoint for nearly all intervention trials seeking preserve beta cell function in recent-onset type 1 diabetes. We hypothesized that participant benefit might be detected earlier and predict outcomes post-therapy. Such findings would support shorter establish initial efficacy.</p><p dir="ltr">Research Design Methods: examined data from 6...
<p dir="ltr">Objective: Mixed meal tolerance test stimulated area under the curve (AUC) C-peptide at 12 to 24 months represents primary endpoint for nearly all intervention trials seeking preserve beta cell function in recent-onset type 1 diabetes. We hypothesized that participant benefit might be detected earlier and predict outcomes post-therapy. Such findings would support shorter establish initial efficacy.</p><p dir="ltr">Research Design Methods: examined data from 6...
This article offers a preliminary sketch of multidimensional model variable constitutional authority rooted in principles and practices popular sovereignty. To do so, it draws on three sets criteria which James Madison relied The Federalist: those based processes authorization, republican governance, commitments to securing rights. These support analysis gradations authority, not only claims that has been present or absent. Taking into account ways the Constitution partially rather than...
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