A5034030410- Diabetes and associated disorders
- Pancreatic function and diabetes
- Sperm and Testicular Function
- Diabetes Management and Research
- Testicular diseases and treatments
- Reproductive Biology and Fertility
- Effects and risks of endocrine disrupting chemicals
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Toxic Organic Pollutants Impact
- Celiac Disease Research and Management
- Birth, Development, and Health
- Urological Disorders and Treatments
- Digestive system and related health
- Diet, Metabolism, and Disease
- Pregnancy-related medical research
- Carcinogens and Genotoxicity Assessment
- Hormonal and reproductive studies
- Reproductive Health and Technologies
- Renal and related cancers
- Immune Cell Function and Interaction
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Hypothalamic control of reproductive hormones
University of Turku
2016-2025
Turku University Hospital
2016-2025
Copenhagen University Hospital
1996-2024
Rigshospitalet
2010-2024
Åbo Akademi University
2024
University of Bonn
2023
University of Oulu
2020-2023
Helmholtz Zentrum München
2020-2023
University of Colorado Anschutz Medical Campus
2020-2023
Lund University
2020-2023
The development of the microbiome from infancy to childhood is dependent on a range factors, with microbial–immune crosstalk during this time thought be involved in pathobiology later life diseases1–9 such as persistent islet autoimmunity and type 1 diabetes10–12. However, our knowledge, no studies have performed extensive characterization early large, multi-centre population. Here we analyse longitudinal stool samples 903 children between 3 46 months age by 16S rRNA gene sequencing (n =...
Type 1 diabetes (T1D) is an autoimmune disease that targets pancreatic islet beta cells and incorporates genetic environmental factors1, including complex elements2, patient exposures3 the gut microbiome4. Viral infections5 broader dysbioses6 have been identified as potential causes or contributing factors; however, human studies not yet microbial compositional functional triggers are predictive of autoimmunity T1D. Here we analyse 10,913 metagenomes in stool samples from 783 mostly white,...
Phthalates adversely affect the male reproductive system in animals. We investigated whether phthalate monoester contamination of human breast milk had any influence on postnatal surge hormones newborn boys as a sign testicular dysgenesis.DesignWe obtained biologic samples from prospective Danish–Finnish cohort study cryptorchidism 1997 to 2001. analyzed individual collected additive aliquots 1–3 months postnatally (n = 130; 62 cryptorchid/68 healthy boys) for monoesters [mono-methyl (mMP),...
Recent reports have indicated a decrease in semen quality of men some countries, and suggested regional differences. A study was undertaken samples from 1082 fertile four European cities (Copenhagen, Denmark; Paris, France; Edinburgh, Scotland; Turku, Finland). Semen analysis standardized, inter-laboratory differences assessment sperm concentration were evaluated, morphology centralized. Lowest concentrations total counts detected for Danish men, followed by French Scottish men. Finnish had...
Polybrominated diphenyl ethers (PBDEs) are widely used in Western countries.Because the prevalence of cryptorchidism appears to be increasing, we investigated whether exposure PBDEs was associated with testicular maldescent.In a prospective Danish-Finnish study, 1997-2001, all boys were examined for cryptorchidism. We analyzed whole placentas (for 95 cryptorchid/185 healthy boys) and individual breast milk samples (62/68) 14 infant serum gonadotropins, sex-hormone binding globulin,...
Serono Symposia International convened an expert panel to review the impact of environmental influences on regulation pubertal onset and progression while identifying critical data gaps future research priorities. An reviewed literature endocrine-disrupting chemicals, body size, puberty. The concluded that available experimental animal human support a possible role chemicals size in relation alterations boys girls. Critical prioritized for initiatives include (1) etiologic focus...
More than half of pregnant women in the Western world report intake mild analgesics, and some these drugs have been associated with anti-androgenic effects animal experiments. Intrauterine exposure to anti-androgens is suspected contribute recent increase male reproductive problems, many compounds are like analgesics potent inhibitors prostaglandin synthesis. Therefore, it appears imperative further investigate potential endocrine disrupting properties analgesics. In a prospective birth...
Considerable interest and controversy over a possible decline in semen quality during the 20th century raised concern that could have reached critically low level where it might affect human reproduction. The authors therefore initiated study to assess reproductive health men from general population monitor changes time.Cross-sectional of Danish population. Inclusion criteria were place residence Copenhagen area, both man his mother being born Denmark. Men with severe or chronic diseases not...
The incidence of the autoimmune disease, type 1 diabetes (T1D), has increased dramatically over last half century in many developed countries and is particularly high Finland other Nordic countries. Along with genetic predisposition, environmental factors are thought to play a critical role this increase. As diseases, gut microbiome potential controlling progression T1D children risk, but we know little about how develops risk for T1D. In study, early development microbiomes 76 at was...
Gynecomastia (GM) is a benign proliferation of the glandular tissue breast in men. It frequent condition with reported prevalence 32-65%, depending on age and criteria used for definition. GM infancy puberty are common, conditions resolving spontaneously majority cases. adulthood more prevalent among elderly proper investigation may reveal an underlying pathology 45-50% cases.The aim was to provide clinical practice guidelines evaluation management GM.A literature search articles English...