A5020031001- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adolescent and Pediatric Healthcare
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Health and Lifestyle Studies
- Birth, Development, and Health
- Metabolism and Genetic Disorders
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Function and Risk Factors
- Retinal Diseases and Treatments
- Genetic Neurodegenerative Diseases
University of Pennsylvania
2015-2025
Children's Hospital of Philadelphia
2016-2025
Nemours Children's Health System
2022
Philadelphia University
2012-2021
University of Oklahoma Health Sciences Center
2018
Henry Ford Health System
2017
University Hospitals of Cleveland
2017
SUNY Upstate Medical University
2017
Indiana University – Purdue University Indianapolis
2017
Women & Children's Hospital of Buffalo
2017
Recently developed technologies for the treatment of type 1 diabetes mellitus include a variety pumps and with glucose sensors.In this 1-year, multicenter, randomized, controlled trial, we compared efficacy sensor-augmented pump therapy (pump therapy) that regimen multiple daily insulin injections (injection in 485 patients (329 adults 156 children) inadequately diabetes. Patients received recombinant analogues were supervised by expert clinical teams. The primary end point was change from...
The Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) cohort represents the largest best-characterized national sample of American youth with recent-onset type diabetes.The objective study was to describe baseline characteristics participants TODAY randomized clinical trial.Participants were recruited over 4 yr at 15 centers United States (n = 704) enrolled, randomized, treated, followed up 2-6 yr.The conducted pediatric diabetes care clinics practices.Eligible aged...
Adolescents and young adults with type 1 diabetes exhibit the worst glycemic control among individuals across lifespan. Although continuous glucose monitoring (CGM) has been shown to improve in adults, its benefit adolescents not demonstrated.To determine effect of CGM on diabetes.Randomized clinical trial conducted between January 2018 May 2019 at 14 endocrinology practices US including 153 aged 24 years screening hemoglobin A1c (HbA1c) 7.5% 10.9%.Participants were randomized 1:1 undergo...
BACKGROUND AND OBJECTIVES: Previous research has documented racial/ethnic disparities in diabetes treatments and outcomes. It remains controversial whether these result from differences socioeconomic status (SES) or other factors. We examined therapeutic modalities outcomes among the large number of pediatric participants T1D Exchange Clinic Registry. METHODS: The cohort included 10 704 aged <18 years with type 1 for ≥1 year (48% female; mean age: 11.9 ± 3.6 years; duration: 5.2 3.5...
Background: Debate exists as to whether the higher hemoglobin A1c (HbA1c) levels observed in black persons than white are due worse glycemic control or racial differences glycation of hemoglobin. Objective: To determine a difference relationship mean glucose and HbA1c. Design: Prospective, 12-week observational study. Setting: 10 diabetes centers United States. Participants: 104 aged 8 years older who had type 1 for at least 2 an HbA1c level 6.0% 12.0%. Measurements: Mean concentration,...
BACKGROUND. Type 1 diabetes (T1D) results from destruction of pancreatic β cells by autoreactive effector T cells. We hypothesized that the immunomodulatory drug alefacept would result in targeted quantitative and qualitative changes prolonged preservation endogenous insulin secretion remaining patients with newly diagnosed T1D.
OBJECTIVE This study was conducted to determine if type 1 diabetes is associated with an increased risk of fracture across the life span. RESEARCH DESIGN AND METHODS population-based cohort used data from The Health Improvement Network (THIN) in U.K. (data 1994 2012), which 30,394 participants aged 0–89 years were compared 303,872 randomly selected age-, sex-, and practice-matched without diabetes. Cox regression analysis hazard ratios (HRs) for incident RESULTS A total 334,266 participants,...
Severe hypoglycemia (SH) and diabetic ketoacidosis (DKA) are common serious acute complications of type 1 diabetes (T1D). The aim this study was to determine the frequency SH DKA identify factors related their occurrence in T1D Exchange pediatric young adult cohort.
To determine the minimum sample of continuous glucose monitoring (CGM) data needed to accurately reflect 3 months glycemic control.Three CGM were collected on 257 individuals (age 10-78 years) with type 1 diabetes in two studies (one using Abbott FreeStyle Libre Pro™ and other Dexcom™ G4). Correlations calculated between full incremental sampling periods data.Correlation improved an increasing number days collection, plateauing by about 14 days, R2 value 0.84-0.86 for mean glucose, time at...
Abstract Context Minority young adults (YA) currently represent the largest growing population with type 1 diabetes (T1D) and experience very poor outcomes. Modifiable drivers of disparities need to be identified, but are not well-studied. Objective To describe racial-ethnic among YA T1D identify glycemic disparity other than socioeconomic status (SES). Design Cross-sectional multicenter collection patient chart-reported variables, including SES, social determinants health, diabetes-specific...
Congenital osteopetrosis is a rare osteosclerotic bone disease characterized by both defect in osteoclastic function and reduced generation of superoxide leukocytes. The frequently fatal during the first decade life. A six-month trial therapy with recombinant human interferon gamma-1b eight patients provided evidence benefit, prompting this study more prolonged therapy.
Human uncoupling protein 3 (UCP3) is a mitochondrial transmembrane carrier that uncouples oxidative ATP phosphorylation. With the capacity to participate in thermogenesis and energy balance, UCP3 an important obesity candidate gene. A missense polymorphism exon (V102I) was identified obese diabetic proband. mutation introducing stop codon 4 (R143X) terminal splice donor junction of 6 were also compound heterozygote morbidly diabetic. Allele frequencies polymorphisms determined found be...
Slover RH, Welsh JB, Criego A, Weinzimer SA, Willi SM, Wood MA, Tamborlane WV. Effectiveness of sensor-augmented pump therapy in children and adolescents with type 1 diabetes the STAR 3 study. Objective: Maintenance appropriate A1C values minimization hyperglycemic excursions are difficult for many pediatric patients diabetes. Continuous glucose monitoring (CGM) (SAP) is an alternative to multiple daily injection (MDI) this population. Research design methods: Sensor-augmented reduction...
Type 2 diabetes (T2D) in youth is recognized as a pediatric disease, but few reports describe the characteristics during diagnosis. We clinical presentation of 503 with T2D.The Pediatric Diabetes Consortium (PDC) T2D Clinic Registry enrolled participants from eight centers USA. Clinical and laboratory at time diagnosis were analyzed.In total 67% presented symptoms confirming data, 33% identified by testing risk children, 11% diabetic ketoacidosis (DKA), 2% hyperglycemic hyperosmolar state...
OBJECTIVE Abnormally elevated proinsulin secretion has been reported in type 2 and early 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing low or absent secretory capacity retained the ability to make proinsulin. RESEARCH DESIGN AND METHODS were measured fasting stimulated sera from 319 subjects (≥3 years) 12 control without diabetes. considered three categories of C-peptide: 1) positive, high values ≥0.2 nmol/L; 2) ≥0.017 but <0.2...
BackgroundType 1 diabetes results from autoimmune-mediated destruction of β cells. The tyrosine kinase inhibitor imatinib might affect relevant immunological and metabolic pathways, preclinical studies show that it reverses prevents diabetes. Our aim was to evaluate the safety efficacy in preserving β-cell function patients with recent-onset type diabetes.MethodsWe did a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Patients (<100 days diagnosis), aged 18–45...
OBJECTIVE To evaluate the frequency of depressive symptoms and diagnosis management depression in youth with type 1 diabetes (T1D) 2 (T2D) enrolled Pediatric Diabetes Consortium T1D T2D registries. RESEARCH DESIGN AND METHODS The Children’s Depression Inventory (CDI) Self-Report (Short) version was completed by 261 339 aged 10–17 years. RESULTS Symptoms were identified 13% 22% (P = 0.007) participants; these, only 4% 9% treated a therapist within prior 12 months. Depressive associated lower...
OBJECTIVE Racial/ethnic disparities in continuous glucose monitor (CGM) use exist among children with type 1 diabetes. It is not known whether differential rates of device initiation or sustained are the cause this disparity. Our objective was to compare CGM and continued non-Hispanic White (NHW), Black (NHB), Hispanic children. RESEARCH DESIGN AND METHODS We conducted a retrospective review including diabetes attending Children’s Hospital Philadelphia between January 2015 31 December 2018....