A5102802719- Diabetes and associated disorders
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Astronomical Observations and Instrumentation
- Diabetes Management and Research
- Astronomy and Astrophysical Research
- Stellar, planetary, and galactic studies
- Silicon Carbide Semiconductor Technologies
- Healthcare Policy and Management
- Inflammatory Bowel Disease
- T-cell and B-cell Immunology
- interferon and immune responses
- Microtubule and mitosis dynamics
- History of Science and Medicine
- Sphingolipid Metabolism and Signaling
- Connective tissue disorders research
- Thin-Film Transistor Technologies
- Silicon and Solar Cell Technologies
- Underwater Acoustics Research
- Animal Vocal Communication and Behavior
- Diet, Metabolism, and Disease
- Geology and Paleoclimatology Research
- Marine animal studies overview
- Inflammasome and immune disorders
- Advanced Glycation End Products research
Scripps Institution of Oceanography
2019-2025
University of California, San Diego
2019-2025
Eastern Virginia Medical School
2013-2022
Brandeis University
2018
Brigham Young University
2017
Hôpital Beau-Séjour
2013
Synlab Czech (Czechia)
2013
St. Vincent's Birmingham
2013
University of Virginia
2004-2010
Norfolk and Norwich University Hospital
2010
The initiating etiologic factor in Crohn's disease (CD) remains unclear. SAMP1/YitFc (SAMP) mice develop chronic ileitis similar to human CD. We used bone marrow chimeras determine if SAMP results from a primary immunological defect or dysregulated mucosal immunity secondary intrinsic, nonhematopoietic (e.g., epithelial) dysfunction. receiving wild-type (AKR) BM developed severe ileitis, whereas did not confer WT recipients. lymphocytes reconstituted resembled native populations regard...
OBJECTIVE Abnormally elevated proinsulin secretion has been reported in type 2 and early 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing low or absent secretory capacity retained the ability to make proinsulin. RESEARCH DESIGN AND METHODS were measured fasting stimulated sera from 319 subjects (≥3 years) 12 control without diabetes. considered three categories of C-peptide: 1) positive, high values ≥0.2 nmol/L; 2) ≥0.017 but <0.2...
SAMP1/YitFc mice develop discontinuous, transmural inflammatory lesions in the terminal ileum, similar to what is found human Crohn disease. Compared with mesenteric lymph nodes (MLNs) of AKR control mice, MLNs contain a 4.3-fold expansion total B cell number and 2.5-fold increased percentage CD4+ T cells expressing αEβ7 integrin. Although αEβ7+CD4+ possess regulatory phenotype (CD25+, L-selectinlo, CD45RBlo), express IL-10, suppress effector proliferation vitro, they cannot prevent ileitis...
12/15-lipoxygenase (12/15-LO), one of a family fatty acid oxidoreductase enzymes, reacts with polyenoic acids to produce proinflammatory lipids. 12/15-LO is expressed in macrophages and pancreatic beta-cells. It enhances interleukin 12 production by macrophages, several its products induce apoptosis beta-cells at nanomolar concentrations vitro. We had previously demonstrated role for beta-cell damage the streptozotocin model diabetes. Since gene encoding (gene designation Alox15) lies within...
L-selectin ligands might be relevant for inflammatory cell trafficking into the small intestine in a spontaneous model of chronic ileitis (i.e., SAMP1/YitFc mice). Immunoblockade peripheral node addressin or mucosal adhesion molecule 1 failed to ameliorate ileitis, whereas P-selectin glycoprotein ligand (PSGL-1) neutralization attenuated both adoptively transferred and disease. PSGL-1 was detected venules mesenteric lymph by immunohistochemistry confirmed real-time reverse transcription...
SAMP1/YitFc mice develop discontinuous, transmural inflammatory lesions in the terminal ileum, similar to what is found human Crohn disease. Compared with mesenteric lymph nodes (MLNs) of AKR control mice, MLNs contain a 4.3-fold expansion total B cell number and 2.5-fold increased percentage CD4+ T cells expressing αEβ7 integrin. Although αEβ7+CD4+ possess regulatory phenotype (CD25+, L-selectinlo, CD45RBlo), express IL-10, suppress effector proliferation vitro, they cannot prevent ileitis...
FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) is an orally available immunomodulatory agent that induces severe peripheral blood lymphopenia. Most studies of these lymphopenic effects have been limited to short-term exposure FTY720. alters the ability lymphocytes respond sphingosine-1-phosphate (S1P) through S1P receptors, particularly S1P1. affects different leukocyte populations and their trafficking major lymphoid organs. We show dynamics CD4 T, CD8 B...
view Abstract Citations (63) References (4) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Observations of cs, HCN, U89.2, and U90.7 in NGC 2264 Zuckerman, B. ; Morris, M. Palmer, Patrick Turner, E. The young cluster is a rich source millimeter-wavelength molecular lines potentially good candidate for detection an infrared nebula. Because the narrow line widths ( 3 km ) HCN hyperfine structure resolved. Improved rest frequencies unidentified U89.2 (X-ogen)...
Type 1 diabetes (T1D) is characterized by autoimmune depletion of insulin-producing pancreatic beta cells. We showed previously that deletion the 12/15-lipoxygenase enzyme (12/15-LO, Alox15 gene) in NOD mice leads to nearly 100 percent protection from T1D. In this study, we test hypothesis cytokines involved IL-12/12/15-LO axis affect both macrophage and islet function, which contributes development T1D.12/15-LO expression was clarified immune cells qRT-PCR, timing tested islets using...
We use optical trapping to continuously bend an isolated microtubule while simultaneously measuring the applied force and resulting filament strain, thus allowing us determine its elastic properties over a wide range of strains. find that, in low-strain regime, microtubules may be quantitatively described terms classical Euler-Bernoulli filament, above critical strain they deviate from this simple model, showing softening response with increasingdeformations. A three-dimensional thin-shell...
Type 1 diabetes is a disorder of immune tolerance that leads to death insulin-producing islet β cells. We hypothesize inflammatory signaling within cells promotes progression autoimmunity the microenvironment. To test this hypothesis, we deleted proinflammatory gene encoding 12/15-lipoxygenase (Alox15) in non-obese diabetic mice at pre-diabetic time point when inflammation feature. Deletion Alox15 preservation cell mass, reduces populations infiltrating T cells, and protects against...
Aims/Hypothesis Multiple studies associated enterovirus (EV) infections with type 1 diabetes. The Network for Pancreatic Organ Donors Diabetes (nPOD) obtained samples from organ donors with/without diabetes and launched the nPOD-Virus Group to examine viral in donor tissues, using complementary approaches. To this end, we aimed identify virus proteins/peptides disease-stratified tissues proteomic liquid chromatography-mass spectrometry. Methods nPOD provided specimens four groups: without...
We report ${T}_{2}$ spin coherence times for electronic states localized in Si vacancies $4H\text{\ensuremath{-}}\mathrm{SiC}$. Our study included two SiC samples that were irradiated with 2 MeV protons at different fluences (${10}^{13}$ and ${10}^{14}\phantom{\rule{0.16em}{0ex}}\mathrm{c}{\mathrm{m}}^{\ensuremath{-}2}$) order to create unique defect concentrations. Using optically detected magnetic resonance echo, the each sample measured across a range of temperatures from 8 295 K. All...
FTY720 modulates lymphocyte trafficking through blood (peripheral lymphocyte, PBL) and peripheral lymph nodes (PLN). Treatment with causes retention of most lymphocytes in PLN. Long-term treatment can slow and/or prevent Type 1 diabetes (T1D) the nonobese diabetic (NOD) mouse model. B T cells are both affected by binding to sphingosine-1-phosphate receptor (S1P1). However, little has been done elucidate which T-cell subsets differentially under healthy conditions, how this affects disease...
Accurate representation of cloud microphysical processes in numerical weather and climate models has proven challenging, part because the highly specialized instrumentation required for diagnosing errors simulated distributions hydrometeors. Global Navigation Satellite System (GNSS) polarimetric radio occultation (PRO) is a promising new technique that sensitive to hydrometeors potential help address these challenges by providing observations are relevant larger spatial scales, especially if...
The clinical expression of dopa-responsive dystonia (DRD) was found to be different in a pair affected monozygotic twins. An earlier onset associated with more disabling course disease. Whereas monozygosity genetically proven, the search for pathogenic mutations GTP-cyclohydrolase-1 gene negative. contribution environmental factors appeared minimal. Intrafamilial variability DRD phenotype may related yet unknown non-Mendelian epigenetic or proteomic factors.
Planetary nebulae (PNe) provide tests of stellar evolution, can serve as tracers chemical evolution in the Milky Way and other galaxies, are also used a calibrator cosmological distance ladder. Current upcoming large scale photometric surveys have potential to complete census PNe our galaxy beyond, but it is challenge disambiguate partially or fully unresolved from myriad sources observed these surveys. Here we carry out synthetic observations nebular models determine $ugrizy$ color-color...
Acoustic methods to search for submerged archaeological sites have shown that concentrations of knapped flint produce a visible acoustic response in chirp sonar profiles variety geographical settings. Field tests and simulations suggested the lithic signal is due resonances flaked stone. We model measure resonant signatures chert, obsidian, metavolcanic, granitic debitage. Struck lithics multiple peaks under 30 kHz, with high quality factors decrease material coarseness. use combination...