A5050756282- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- TGF-β signaling in diseases
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Chronic Myeloid Leukemia Treatments
- Nerve injury and regeneration
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- Cancer Cells and Metastasis
- Rabies epidemiology and control
- Metabolism, Diabetes, and Cancer
- Tissue Engineering and Regenerative Medicine
- RNA Research and Splicing
- Kruppel-like factors research
- RNA Interference and Gene Delivery
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
PLA Navy General Hospital
2015-2025
Jinan University
2024
The First Affiliated Hospital, Sun Yat-sen University
2016-2024
Zhongshan Hospital
2016-2024
Fudan University
2011-2024
Sun Yat-sen University
2016-2024
Binzhou Medical University
2014-2024
First Affiliated Hospital of Fujian Medical University
2017-2024
Fujian Medical University
2017-2024
Guangxi Medical University
2007-2024
The BCR-ABL tyrosine kinase inhibitor imatinib is effective in Philadelphia chromosome-positive (Ph-positive) leukemias, but relapse occurs, mainly as a result of the outgrowth leukemic subclones with imatinib-resistant mutations. We evaluated dasatinib, that targets most mutations, patients chronic myelogenous leukemia (CML) or Ph-positive acute lymphoblastic (ALL).Patients various phases CML ALL who could not tolerate were resistant to enrolled phase 1 dose-escalation study. Dasatinib (15...
Adjuvant breast cancer therapy significantly improves survival, but overtreatment and undertreatment are major problems. Breast expression profiling has so far mainly been used to identify women with a poor prognosis as candidates for adjuvant without demonstrated value prediction.We obtained the gene profiles of 159 population-derived patients, hierarchical clustering signature associated impact therapies, defined distant metastasis or death within 5 years. Independent datasets 76 treated...
Abstract Dasatinib is a multitargeted kinase inhibitor that was recently approved for the treatment of chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphoblastic with resistance or intolerance to prior therapy. It also in clinical trials treating patients solid tumors. The identification molecular markers predictive response dasatinib could assist development by selecting most likely derive benefit. Using baseline gene expression profiling panel 23 breast cancer...
This work reports a microfluidic device with deterministic lateral displacement (DLD) arrays allowing rapid and label-free cancer cell separation enrichment from diluted peripheral whole blood, by exploiting the size-dependent hydrodynamic forces. Experiment data theoretical simulation are presented to evaluate isolation efficiency of various types cells in DLD structure. We also demonstrated use both circular triangular post for solution blood samples. The was able achieve high factor our...
Abstract Background and Aims The study objective was to compare the effectiveness of microwave ablation (MWA) laparoscopic liver resection (LLR) on solitary 3–5‐cm HCC over time. Approach Results From 2008 2019, 1289 patients from 12 hospitals were enrolled in this retrospective study. Diagnosis all lesions based histopathology. Propensity score matching used balance baseline variables between two groups 2008–2019 ( n = 335 each group) 2014–2019 257 cohorts, respectively. For cohort...
TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer tissue fibrosis. is tightly regulated at different levels along the pathway, modulation receptor activity a critical step for regulation. This review focuses on our recent understanding regulation activity.
Abstract Overexpression and enhanced activity of insulin-like growth factor-I receptor (IGF-IR) in diverse tumor types make it an attractive target for cancer therapy. BMS-536924 is a potent small molecule inhibitor IGF-IR, which shows antitumor multiple models, including sarcoma. To facilitate the development IGF-IR inhibitors as therapy, identification biomarkers selecting patients most likely to derive clinical benefit needed. do so, 28 sarcoma neuroblastoma cell lines were screened vitro...
Abstract Purpose: We previously reported an insulin-like growth factor (IGF) gene expression signature, based on genes induced or repressed by IGF-I, which correlated with poor prognosis in breast cancer. tested whether the IGF signature was affected anti–IGF-I receptor (IGF-IR) inhibitors and response to a dual anti–IGF-IR/insulin (InsR) inhibitor, BMS-754807. Experimental Design: An examined human tumors cell lines changes were noted following treatment of xenografts anti–IGF-IR antibodies...
IFITM3, an IFN-inducible gene, is overexpressed in human colorectal cancer. In this study, we sought to determine the clinical significance and underlying mechanisms of its dysregulated expression colon tumor specimens murine models disease.IFITM3 a tissue microarray matched normal lymph node metastasis obtained from 203 patients with cancer was measured immunohistochemically.IFITM3 expressed at higher levels tumors and, particularly, nodal metastases than tissue. A Cox proportional hazards...
Overexpressed genes in tumors usually contributed to aggressiveness pancreatic ductal adenocarcinoma (PDAC). Using Gene Expression Omnibus (GEO) profiles including GSE46234, GSE71989, and GSE107610, we detected overexpressed with R program, which were enriched by Kyoto Encyclopedia of Genes Genomes (KEGG), ontology (GO), Reactome pathway databases. Then, performed a survival analysis based on TCGA profile. Our results revealed that high BUB1B, CCNA2, CDC20, CDK1 expression was significantly...
Colorectal cancers displaying high-degree microsatellite instability (MSI-H) have an improved prognosis compared to stable (MSS) cancers. The observation of pronounced lymphocytic infiltrates suggests that MSI-H are inherently more immunogenic. We aimed compare the gene expression profiles and MSS provide evidence for activated immune response in former. analysed tissue from 133 colorectal cancer patients with full consent Local Ethics Committee approval. Genomic DNA was BAT-26. High-quality...
Abstract Agents targeting insulin-like growth factor-I receptor (IGF-IR), including antibodies and small-molecule inhibitors, are currently in clinical development for the treatment of cancers sarcoma. However, resistance is a common phenomenon resulting failures anticancer therapies. In light this problem, we developed two resistant models from rhabdomyosarcoma cell line Rh41: Rh41-807R, with acquired to BMS-754807, dual-kinase inhibitor IGF-IR insulin (IR), Rh41-MAB391R, MAB391, an...
Metastatic prostate cancer (PCa) is one of the leading causes death from in men. The molecular mechanisms underlying transition localized tumor to hormone-refractory metastatic PCa remain largely unknown, and their identification key for predicting prognosis targeted therapy. Here we demonstrated that increased expression a splice variant Kruppel-like factor 6 (KLF6) suppressor gene, known as KLF6-SV1, tumors men after prostatectomy predicted markedly poorer survival disease recurrence...
Our study was approved by the Medical Ethics Committee of Tang Du Hospital, Fourth Military University and complied strictly with national ethical guidelines. Preeclampsia (PE) is a specific clinical disorder characterized gestational hypertension proteinuria leading cause maternal perinatal mortality worldwide. The miR-519d-3p upregulated in plasma patients PE which indicates possible association between this microRNA pathogenesis PE. No studies to date have addressed effect on invasion...
Purpose: The high fatality-to-case ratio of ovarian cancer is directly related to platinum resistance. Exportin-1 (XPO1) a nuclear exporter that mediates export multiple tumor suppressors. We investigated possible clinicopathologic correlations XPO1 expression levels and evaluated the efficacy inhibition as therapeutic strategy in platinum-sensitive -resistant cancer.Experimental Design: were analyzed define correlates using both TCGA/GEO datasets tissue microarrays (TMA). effect inhibition,...
TGFβ signaling inhibits cell proliferation to block cancer initiation, yet it also enhances metastasis promote malignancy during breast development. The mechanisms underlying these differential effects are still unclear. Here, we report that HER2/EGFR switches function in cells from antiproliferation promotion. Inhibition of activity attenuated TGFβ-induced epithelial-mesenchymal transition and migration but enhanced the antiproliferative TGFβ. Activation induced phosphorylation Smad3 at...
Dasatinib is a potent, multi-targeted kinase inhibitor that was recently approved for treatment of chronic myelogenous leukemia resistant to imatinib. To aid the clinical development dasatinib in prostate cancer, we utilized preclinical models identify potential molecular markers patient stratification and efficacy monitoring.Using gene expression profiling, first identified 174 genes whose highly correlated with vitro sensitivity 16 cell lines and, thus, considered as candidate predictive...
Abstract Insulin-like growth factor (IGF) signaling has been implicated in the resistance to hormonal therapy breast cancer. Using a model of postmenopausal, estrogen-dependent cancer, we investigated antitumor effects dual IGF-1R/InsR tyrosine kinase inhibitor BMS-754807 alone and combination with letrozole or tamoxifen. exhibited antiproliferative vitro that synergized strongly 4-hydroxytamoxifen fulvestrant. Similarly, combined treatment either tamoxifen vivo elicited tumor regressions...
Abstract Background The central nervous system (CNS) is vulnerable to viral infection, yet few host factors in the CNS are known defend against invasion by neurotropic viruses. Long noncoding RNAs (lncRNAs) have been revealed play critical roles a wide variety of biological processes and highly abundant mammalian brain, but their defending pathogens into remain unclear. Results We report here that multiple viruses, including rabies virus, vesicular stomatitis Semliki Forest herpes simplex...
Highlights•Upon DNA damage, ATM activates TGF-β signaling by stabilizing the receptor TβRII•ATM phosphorylates and stabilizes c-Cbl, which enhances TβRII neddylation•DNA damage interaction among ATM, TβRII•The ATM-c-Cbl-TβRII axis plays a pivotal role in intestinal regenerationSummaryActivation of both response (DDR) transforming growth factor β (TGF-β) induces arrest most cell types. However, it is unclear whether DDR that turn contributes to arrest. Here, we show ataxia telangiectasia...