A5038764617- Neurogenesis and neuroplasticity mechanisms
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- MicroRNA in disease regulation
- Neuropeptides and Animal Physiology
- Acupuncture Treatment Research Studies
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Pain Management and Placebo Effect
- Neuroscience and Neuropharmacology Research
- Magnolia and Illicium research
- Machine Learning in Materials Science
- Apelin-related biomedical research
- Nuclear Receptors and Signaling
- Histone Deacetylase Inhibitors Research
- Advanced Graph Neural Networks
- Machine Learning in Bioinformatics
- Metabolomics and Mass Spectrometry Studies
- Privacy-Preserving Technologies in Data
- Protein Kinase Regulation and GTPase Signaling
- Genetics, Aging, and Longevity in Model Organisms
- Axon Guidance and Neuronal Signaling
- Computational Drug Discovery Methods
- Memory and Neural Mechanisms
- Epigenetics and DNA Methylation
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2021-2025
Shanghai Stomatological Hospital
2025
Capital Medical University
2025
University of Chinese Academy of Sciences
2016-2024
Zhejiang Chinese Medical University
2022-2024
Tsinghua–Berkeley Shenzhen Institute
2024
Tsinghua University
2024
China Pharmaceutical University
2018-2022
Emory University
2022
Dalian Naval Academy
2012-2022
Abstract The intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by actively proliferating Lgr5 + stem cells. Bone morphogenetic protein (BMP) signalling represents one major counterforce that limits the hyperproliferation of epithelium, but exact mechanism remains elusive. Here we demonstrate epithelial BMP plays an indispensable role in restricting cell expansion to maintain homeostasis and prevent premalignant on damage. Mechanistically, inhibits stemness...
Abstract The applications of self-assembled InAs/GaAs quantum dots (QDs) for lasers and single photon sources strongly rely on their density quality. Establishing the process parameters in molecular beam epitaxy (MBE) a specific QDs is multidimensional optimization challenge, usually addressed through time-consuming iterative trial-and-error. Here, we report real-time feedback control method to realize growth with arbitrary density, which fully automated intelligent. We develop machine...
TGFβ signaling inhibits cell proliferation to block cancer initiation, yet it also enhances metastasis promote malignancy during breast development. The mechanisms underlying these differential effects are still unclear. Here, we report that HER2/EGFR switches function in cells from antiproliferation promotion. Inhibition of activity attenuated TGFβ-induced epithelial-mesenchymal transition and migration but enhanced the antiproliferative TGFβ. Activation induced phosphorylation Smad3 at...
Anxiety is a common comorbidity associated with chronic pain, which results in pain complexification and difficulty treatment. Electroacupuncture (EA) commonly used to treat anxiety. However, the underlying mechanisms of EA effect are largely unknown. Here, we showed that circuitry induces anxiety disorders, can them by regulating such circuitry. Using chemogenetic methods, found activation rostral anterior cingulate cortex (rACC) glutamatergic output thalamus induced disorders control rats....
Abstract Although electroacupuncture (EA) stimulation is a widely used therapy for chronic pain and comorbid psychiatric disorders, its long-term effects on neuropathic pain-induced depression the underlying mechanisms remain elusive. In present study, we found that EA was able to restore adult neurogenesis in ventral dentate gyrus (DG), by both increasing neuronal differentiation restoring normal morphology of newborn dendrites, mice with spared nerve injury surgery. By ablating Nestin+...
Pain memory is commonly considered an underlying cause of chronic pain and also responsible for a range anxiety. Electroacupuncture (EA) has been shown to ameliorate memories exert anti-anxiety effects. Previous research indicated that GABAergic neurons and/or GABA receptors (GABARs) in the midcingulate cortex (MCC) have potential associations with However, there no known empirical specifically studied effects EA on system MCC. Here, we used cross-injection carrageenan establish rats model....
The mechanism by which addictive drugs such as morphine regulate adult neurogenesis remains elusive. We now demonstrate that can control of miR-181a and subsequent hippocampal neural progenitor cell (hNPC) lineages. In the presence morphine, hNPCs preferentially differentiated into astrocytes, an effect blocked specific μ-opioid receptor antagonist, Cys(2)-Tyr(3)-Orn(5)-Pen(7)-amide. This was mediated Prox1/Notch1 pathway demonstrated increase in Notch1 level morphine- but not...
Abstract Implant‐associated infections are the most critical threat to orthopedic surgeries. Various surface‐modification strategies developed impart antibacterial properties and osteogenesis‐promoting abilities surfaces of implants. Nevertheless, a straightforward strategy for constructing functional, stable, bioactive implant surface remains challenging. Here, facile one‐step surface‐bioactivation method is that enhances both anti‐infection capabilities osteointegration performance This...
ABSTRACT Aims Although previous studies have revealed the association between chronic pain‐induced depression and defective adult hippocampal neurogenesis (AHN), underlying molecular mechanism remains elusive. This study aims to examine AHN depression‐like behaviors, reveal mechanisms. Methods The neuropathic pain model was established using mice with spared nerve injury (SNI) surgery. behaviors were evaluated by sucrose preference test (SPT), tail suspension (TST), forced swimming (FST),...
Abstract Artificial intelligence (AI) models usually require large amounts of high-quality training data, which is in striking contrast to the situation small and biased data faced by current drug discovery pipelines. The concept federated learning has been proposed utilize distributed from different sources without leaking sensitive information these data. This emerging decentralized machine paradigm expected dramatically improve success AI-powered discovery. We here simulate process with 7...
Comorbid chronic neuropathic pain and anxiety is a common disease that represents major clinical challenge. The underlying mechanisms of are not entirely understood, which limits the exploration effective treatment methods. Glutamatergic neurons in ventrolateral periaqueductal gray (vlPAG) have been implicated regulating pain, but potential roles vlPAG pain-induced investigated. Herein, whole-cell recording immunofluorescence showed excitability CamkIIα (vlPAG CamkIIα+ neurons) was decreased...
Abstract The opioid receptors are a member of G protein‐coupled that mediate physiological effects endogenous peptides and structurally distinct alkaloids. Although it is well characterized there differential receptor desensitization internalization properties following activation by agonists, the underlying mechanisms remain elusive. We investigated signaling events δ‐opioid (δOR) initiated two ligands, DPDPE TIPP. found although both ligands inhibited adenylyl cyclase (AC) activated...
Previously we have shown that morphine regulates adult neurogenesis by modulating miR-181a maturation and subsequent hippocampal neural progenitor cell (NPC) lineages. Using NPCs cultured from PKCε or β-arrestin2 knockout mice the MAPK/ERK kinase inhibitor U0126, demonstrate regulation of NPC differentiation via miR-181a/Prox1/Notch1 pathway exhibits ligand-dependent selectivity. In NPCs, fentanyl activate ERK PKCε- β-arrestin-dependent pathways, respectively. After exposure, activated...
The regulation of adult neurogenesis by opiates has been implicated in modulating different addiction cycles. At which stage exert their action remains unresolved. We attempt to define the temporal window morphine's inhibition effect on using POMC-EGFP mouse model, newborn granular cells (GCs) can be visualized between days 3-28 post-mitotic. mice were trained under 3-chambers conditioned place preference (CPP) paradigm with either saline or morphine. observed after 4 CPP training saline,...