A5100692863- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Influenza Virus Research Studies
- interferon and immune responses
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Endoplasmic Reticulum Stress and Disease
- Antibiotic Resistance in Bacteria
- RNA Research and Splicing
- Respiratory viral infections research
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Genetic Associations and Epidemiology
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Pancreatic function and diabetes
- Genomics and Phylogenetic Studies
- Mycobacterium research and diagnosis
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
Zhejiang Chinese Medical University
2023-2025
Sichuan Agricultural University
2016-2025
Sichuan Center for Disease Control and Prevention
2023-2025
University of South China
2017-2025
Ministry of Education of the People's Republic of China
2024-2025
Tongde Hospital of Zhejiang Province
2019-2024
Zhejiang Medicine (China)
2023
Fujian Agriculture and Forestry University
2023
Union Hospital
2023
Huazhong University of Science and Technology
2023
More than 60% of patients with hepatocellular carcinoma (HCC) do not receive curative therapy as a result late clinical presentation and diagnosis. We aimed to identify plasma microRNAs for diagnosing hepatitis B virus (HBV) -related HCC.Plasma microRNA expression was investigated three independent cohorts including 934 participants (healthy, chronic B, cirrhosis, HBV-related HCC), recruited between August 2008 June 2010. First, we used microarray screen 723 in 137 samples HCC. Quantitative...
An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing avian-signature residue Gln(226)) and A/Anhui/1/2013 (AH-H7N9) mammalian-signature Leu(226)). found that SH-H7N9 HA preferentially binds avian receptor analog, whereas AH-H7N9 both analogs. Furthermore, an mutant (Leu(226) → Gln) to exhibit dual property,...
Colonoscopy remains the standard screening method for detecting colorectal cancer (CRC) at an early stage. However, many people avoid having a colonoscopy because of fear its potential complications. Our study aimed to identify plasma microRNAs preliminarily CRC in general population, so that some unnecessary colonoscopies can be avoided. We investigated microRNA expression three independent cohorts including discovery (n = 80), training 112), and validation 49) phases recruited two medical...
Effective annual influenza vaccination requires frequent changes in vaccine composition due to both antigenic shift for different subtype hemagglutinins (HAs) and drift a particular HA. Here we present broadly neutralizing human monoclonal antibody with an unusual binding modality. The antibody, designated CT149, was isolated from convalescent patients infected pandemic H1N1 2009. CT149 is found neutralize all tested group 2 some 1 A viruses by inhibiting low pH-induced, HA-mediated membrane...
The present study aimed to verify whether long noncoding RNA (lncRNA) MALAT1 is involved in brain tissue damage induced by ischemia-reperfusion injury, and explore the mechanism which regulates aquaporin 4 (AQP4).In this study, we established glucose deprivation (OGD)/reoxygenation (RX) astrocyte cell model middle cerebral artery occlusion (MCAO)/reperfusion mouse vitro vivo. Then counting kit-8 assay, flow cytometry analysis, Triphenyltetrazolium chloride (TTC) staining, western blotting...
Abstract The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans eastern China since the spring of 2013. Fatal outcomes H7N9 infections are often attributed to pneumonia and acute respiratory distress syndrome (ARDS). There is urgent need discover biomarkers predicting progression disease fatal outcome potentially lethal flu infections, based on sound statistical analysis. We discovered that 34 48 cytokines chemokines examined this study were significantly...
Circulating microRNAs are promising biomarkers for non‐invasive testing and dynamic monitoring in cancer patients. However, no consensus exists regarding the normalization of circulating quantification, making results incomparable. We investigated global microRNA profiles to identify a stable endogenous control quantifying using three cohorts ( n = 544), including 168 individuals (healthy subjects those with chronic hepatitis B cirrhosis) 376 patients (hepatocellular, colorectal, lung,...
Abstract Doxorubicin is conventionally used in chemotherapy against hepatocellular carcinoma (HCC), but acquired resistance developed during long-term therapy limits its benefits. Autophagy, a conserved catabolic process for cellular self-protection and adaptation to the changing environment, regarded as potential clinical target overcome doxorubicin resistance. In this study, role of miR-223 modulating doxorubicin-induced autophagy sensitivity were evaluated four transfected human HCC cell...
Highlights•Plasma microRNA panel built for early diagnosis of lung cancer with high accuracy.•Plasma discrimination between SCLC and NSCLC.•Based on a large cohort 1132 samples collected from five medical centers.•Potential clinical value in treatment via non-invasive blood test.AbstractObjectivesEarly accurate is crucial effective treatment. This study aimed to identify plasma microRNAs further small cell (SCLC) non-small (NSCLC).Materials methodsPlasma expression was investigated using...
// Mingming Lv 1,* , Pengfei Xu Ying Wu Lei Huang 3 Wenqu Li Shanshan 1 Xiaowei 5 Xin Zeng Rong Shen Xuemei Jia Yongmei Yin Yun Gu 2 Hongyan Yuan 1,4 Hui Xie 1,3 and Ziyi Fu Nanjing Maternity Child Health Medical Institute, Affiliated Maternal Hospital, University, Nanjing, China Department of Pathology, First 4 Oncology Lombardi Comprehensive Cancer Center, Georgetown University Washington, D.C., USA Pharmacology, School Basic Sciences, * These authors have contributed equally to this work...
Abstract Colorectal cancer (CRC) is one of the leading causes death worldwide, and metastasis major cause CRC-related mortality. Transforming growth factor-beta (TGF-β) has a central role not only in regulation normal colon but also development CRC. However, TGF-β considered an ideal therapeutic target because it shows both pro-tumorigenic anti-tumorigenic activity, depending on tumor stage. Therefore, important to find downstream signaling component that can be targeted impair CRC...
Liver fibrosis is a critical liver disease that can progress to more severe manifestations, such as cirrhosis, yet no effective targeted therapies are available. Here, we identify ATF4, master transcription factor in ER stress response, promotes by facilitating response-independent epigenetic program hepatic stellate cells (HSCs). Unlike its canonical role regulating UPR genes during stress, ATF4 activates epithelial-mesenchymal transition (EMT) gene under fibrogenic conditions. HSC-specific...
Fosfomycin (FOS) is a critical antibiotic for treating multi-drug resistant (MDR) Enterobacteriaceae infections, but its effectiveness jeopardized by the dissemination of plasmids encoding enzymes that modify FOS. Despite prohibition on use in animal breeding China, 100 strains Escherichia coli ( E. ) exhibiting high resistance to FOS (MIC≥512 mg/L) were isolated from samples waterfowl origin collected Hainan, Sichuan, and Anhui. These commonly carried fos A 3 (88/100, 88.0%). In addition,...
Abstract Bone remodeling involves bone resorption by osteoclasts and synthesis osteoblasts is tightly regulated the receptor activator of NF-κB ligand (RANKL)/receptor (RANK)/osteoprotegerin molecular triad. RANKL, a member TNF superfamily, induces osteoclast differentiation, activation survival upon interaction with its RANK. The decoy osteoprotegerin inhibits formation binding to RANKL. Imbalance in this triad can result diseases, including osteoporosis rheumatoid arthritis. In study, we...
A novel H7N9 influenza virus has been discovered as the causative identity of emerging acute respiratory infection cases in Shanghai, China. This also identified neighboring area Hangzhou City Zhejiang Province. In this study, epidemiologic, clinical, and virological data from three patients who were confirmed to be infected by collected analyzed. Human specimens chicken feces a contacted free market tested for real-time reverse transcription PCR (RT-PCR) sequencing. The clinical features...
mircoRNAs (miRNAs) play important roles on regulation of gene expressions. Aberrant expression miRNAs was involved in various biological and pathological processes, including tumorigenesis breast cancer. Single-nucleotide polymorphisms (SNPs) were implicated altered or functions mature miRNAs. To explore the relevance miRNA female physiological characteristics to cancer risk, SNPs located within hsa-miR-605 (rs2043556), hsa-miR-149 (rs2292832), hsa-miR-27a (rs895819), hsa-miR-196a-2...