A5014810814- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
- Liver Disease and Transplantation
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- Viral Infections and Vectors
- Gut microbiota and health
- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- HIV/AIDS drug development and treatment
- Mesenchymal stem cell research
- Respiratory Support and Mechanisms
- Herpesvirus Infections and Treatments
- COVID-19 diagnosis using AI
- Immune Response and Inflammation
- Vibrio bacteria research studies
- Antibiotic Use and Resistance
- Chronic Lymphocytic Leukemia Research
- Fungal Infections and Studies
Zhejiang Shuren University
2018-2025
Henan Agricultural University
2025
Hangzhou Red Cross Hospital
2018-2023
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2011-2020
Zhejiang University
2010-2020
National Clinical Research
2020
Zhejiang Medicine (China)
2020
First Affiliated Hospital Zhejiang University
2009-2018
Jiangsu Institute of Parasitic Diseases
2009
Abstract Objective To study the clinical characteristics of patients in Zhejiang province, China, infected with 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for disease (covid-2019). Design Retrospective case series. Setting Seven hospitals China. Participants 62 admitted to hospital laboratory confirmed SARS-Cov-2 infection. Data were collected from 10 January 2020 26 2020. Main outcome measures Clinical data, using a standardised report form, such as...
Abstract Background Coronavirus disease 2019 (COVID-19) is an emerging serious global health problem. Gastrointestinal symptoms are common in COVID-19 patients, and severe acute respiratory syndrome coronavirus 2 RNA has been detected stool specimens. However, the relationship between gut microbiome remains to be established. Methods We conducted a cross-sectional study of 30 patients with COVID-19, 24 influenza A(H1N1), matched healthy controls (HCs) identify differences microbiota by 16S...
During the spring of 2013, a novel avian-origin influenza A (H7N9) virus emerged and spread among humans in China. Data were lacking on clinical characteristics infections caused by this virus.Using medical charts, we collected data 111 patients with laboratory-confirmed infection through May 10, 2013.Of studied, 76.6% admitted to an intensive care unit (ICU), 27.0% died. The median age was 61 years, 42.3% 65 years or older; 31.5% female. total 61.3% had at least one underlying condition....
H7N9 viruses quickly spread between mammalian hosts and carry the risk of human-to-human transmission, as shown by 2013 outbreak. Acute respiratory distress syndrome (ARDS), lung failure, acute pneumonia are major diseases in patients. Transplantation mesenchymal stem cells (MSCs) is a promising choice for treating virus-induced pneumonia, was used to treat H7N9-induced ARDS 2013. The transplant MSCs into patients with conducted at single center through an open-label clinical trial. Based on...
BackgroundCarbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the distribution and clinical significance of carbapenemases are unclear. The aim this study was to define characteristics outcomes CRPA infections frequency impact harboured by CRPA.MethodsWe conducted an observational, prospective cohort isolated from bloodstream, respiratory, urine, or wound cultures patients at 44 hospitals (10 countries) between Dec 1, 2018, Nov 30, 2019. Clinical data were abstracted...
SummaryBackgroundCarbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) has been increasingly reported worldwide, posing a severe challenge to public health; however, the mechanisms driving its emergence and global dissemination remain unclear.MethodsWe analysed CR-hvKp strains derived from canonical hvKp backgrounds, acquired carbapenemase-encoding gene. These were identified 485 CRKp isolates in CRACKLE-2 China cohort, 259 multi-centre study, 67,631 K. genomes available...
To determine the impact of adjuvant corticosteroids administered to patients hospitalized with influenza A (H7N9) viral pneumonia.The effects on mortality were assessed using multivariate Cox regression and a propensity score-matched case-control study. Nosocomial infections shedding also compared.Hospitals pneumonia patient admission in 84 cities 16 provinces Mainland China.Adolescent Adult aged >14 yr severe laboratory-confirmed virus screened from April 2013 March 2015.None.The study...
Background. Influenza A(H7N9) viruses isolated from humans show features suggesting partial adaptation to mammals. To provide insights into the pathogenesis of H7N9 virus infection, we compared risk factors, clinical presentation, and progression patients hospitalized with H7N9, H5N1, 2009 pandemic H1N1 (pH1N1) infections.
Abstract The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans eastern China since the spring of 2013. Fatal outcomes H7N9 infections are often attributed to pneumonia and acute respiratory distress syndrome (ARDS). There is urgent need discover biomarkers predicting progression disease fatal outcome potentially lethal flu infections, based on sound statistical analysis. We discovered that 34 48 cytokines chemokines examined this study were significantly...
Abstract COVID-19 is a newly emerging infectious disease, which generally susceptible to human beings and has caused huge losses people's health. Acute respiratory distress syndrome (ARDS) one of the common clinical manifestations severe it also responsible for current shortage ventilators worldwide. This study aims analyze characteristics ARDS patients establish diagnostic system based on artificial intelligence (AI) method predict probability in patients. We collected data 659 from 11...
Coronavirus disease 2019 (COVID-19) broke out and then became a global epidemic at the end of 2019. With increasing number deaths, early identification severity interpretation pathogenesis are very important. Aiming to identify biomarkers for progression COVID-19, 75 COVID-19 patients, 34 healthy controls 23 patients with pandemic influenza A(H1N1) were recruited in this study. Using liquid chip technology, 48 cytokines chemokines examined, among which 33 significantly elevated compared...
Carbapenem-resistant Acinetobacter baumannii (CRAb) is 1 of the most problematic antimicrobial-resistant bacteria. We sought to elucidate international epidemiology and clinical impact CRAb. In a prospective observational cohort study, 842 hospitalized patients with CRAb culture were enrolled at 46 hospitals in five global regions between 2017 2019. The primary outcome was all-cause mortality 30 days from index culture. strains underwent whole-genome analysis. Of cases, 536 (64%) represented...
Background/Aims: Regular physical exercise can enhance resistance to many microbial infections. However, little is known about the mechanism underlying changes in immune system induced by regular exercise. Methods: We recruited members of a university badminton club as (RE) group and healthy sedentary students control (SC) group. investigated distribution peripheral blood mononuclear cell (PBMC) subsets functions two groups. Results: There were no significant differences plasma cytokine...
The gut microbiota has an important role in the pathogenesis of hepatic encephalopathy(HE). Rifaximin, intestinal non-absorbable antibacterial agent, is effective treatment HE. However, whether long-term prophylactic use induces resistance and its mechanism for treating HE remains unclear. This prospective study assessed impact 12 weeks rifaximin administration on resistome cirrhotic patients. Fecal sampling was conducted 1 day before first at Weeks 1, 2, 4, 6, 8, 10, study. Thirty patients...
Safe and effective vaccines are urgently needed to end the COVID-19 pandemic caused by SARS-CoV-2 infection. We aimed assess preliminary safety, tolerability, immunogenicity of an mRNA vaccine ARCoV, which encodes spike protein receptor-binding domain (RBD).This single centre, double-blind, randomised, placebo-controlled, dose-escalation, phase 1 trial ARCoV was conducted at Shulan (Hangzhou) hospital in Hangzhou, Zhejiang province, China. Healthy adults aged 18-59 years negative for...
To the best of our knowledge, no Chinese case studies concerning Nocardia infection have been published to date. Therefore, present study aimed retrospectively evaluate risk factors, clinical features, imaging results, laboratory abnormalities, treatments and outcomes nocardiosis in a tertiary hospital. Data collected from patients with laboratory-confirmed were analyzed. A total 40 who had positive culture included. The median time between onset symptoms diagnosis was 42 days. Underlying...
In January 2015, there was an outbreak of avian-origin influenza A (H7N9) virus in Zhejiang Province, China. 45-year-old man admitted to the First Affiliated Hospital University with a high fever that had lasted 7 days, chills, and cough yellow sputum. Laboratory testing confirmed infection H7N9 virus, likely obtained from contact poultry at local live market. large dense shadow apparent patient's left lung time admission. Treatment oseltamivir (75mg twice daily) did not improve condition....
BACKGROUND. HBV-related acute-on-chronic liver failure (HBV-ACLF) is hallmarked by high short-term mortality rates, calling for accurate prognostic biomarkers initial risk stratification.