A5013718821- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Surgical site infection prevention
- Infection Control in Healthcare
- Streptococcal Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Orthopedic Infections and Treatments
- Enterobacteriaceae and Cronobacter Research
- Sepsis Diagnosis and Treatment
- Vibrio bacteria research studies
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Patient Satisfaction in Healthcare
- Healthcare cost, quality, practices
- Pediatric Urology and Nephrology Studies
- Mycobacterium research and diagnosis
- Medical Device Sterilization and Disinfection
- Neutropenia and Cancer Infections
- Tuberculosis Research and Epidemiology
Johnson University
2021-2025
Rutgers, The State University of New Jersey
2021-2025
Rutgers Sexual and Reproductive Health and Rights
2023-2025
Michigan Medicine
2017-2024
University of Pittsburgh
2023-2024
Lindsay Unified School District
2023-2024
Oregon Medical Research Center
2023-2024
New York Proton Center
2015-2024
Communities In Schools of Orange County
2023-2024
University of Michigan
2016-2023
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Data for 479 patients were analyzed to assess the impact of methicillin resistance on outcomes with Staphylococcus aureus surgical site infections (SSIs). Patients infected methicillin-resistant S. (MRSA) had a greater 90-day mortality rate than did methicillin-susceptible (MSSA; adjusted odds ratio, 3.4; 95% confidence interval, 1.5-7.2). MRSA duration hospitalization after infection (median additional days, 5; P<.001), although this was not significant multivariate analysis (P=.11). Median...
To evaluate the impact of methicillin resistance in Staphylococcus aureus on mortality, length hospitalization, and hospital charges.A cohort study patients admitted to between July 1, 1997, June 2000, who had clinically significant S. bloodstream infections.A 630-bed, urban, tertiary-care teaching Boston, Massachusetts.Three hundred forty-eight with bacteremia were studied; 96 methicillin-resistant (MRSA). Patients methicillin-susceptible (MSSA) MRSA similar regarding gender, percentage...
The polymyxin antibiotics colistin (polymyxin E) and B became available in the 1950s thus did not undergo contemporary drug development procedures. Their clinical use has recently resurged, assuming an important role as salvage therapy for otherwise untreatable gram-negative infections. Since their reintroduction into clinic, significant confusion remains due to existence of several different conventions used describe doses polymyxins, differences formulations, outdated product information,...
The efficacy of ceftazidime-avibactam—a cephalosporin–β-lactamase inhibitor combination with in vitro activity against Klebsiella pneumoniae carbapenemase–producing carbapenem-resistant Enterobacteriaceae (CRE)—compared colistin remains unknown. Patients initially treated either ceftazidime-avibactam or for CRE infections were selected from the Consortium on Resistance Against Carbapenems and other (CRACKLE), a prospective, multicenter, observational study. Efficacy, safety, benefit-risk...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections. The intent of this document is to highlight practical in a concise format designed assist acute care hospitals implement prioritize their surgical site infection (SSI) prevention efforts. Refer the Society Healthcare Epidemiology America/Infectious Diseases America “Compendium Strategies Prevent Healthcare-Associated Infections” Executive...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections. The intent of this document is to highlight practical in a concise format designed assist acute care hospitals implementing prioritizing their central line–associated bloodstream infection (CLABSI) prevention efforts. Refer the Society Healthcare Epidemiology America/Infectious Diseases America “Compendium Strategies Prevent...
We studied outcomes of extended-spectrum beta-lactamase (ESBL) production in Enterobacteriaceae bacteremia. Inpatients with bacteremia caused by ESBL-producing Escherichia coli, Klebsiella spp., or Proteus spp. (cases) were compared patients non-ESBL producers (controls). Outcomes included mortality, mortality due to infection, length stay (LOS), delay appropriate therapy (DAT), discharge a chronic care facility, and hospital cost. Ninety-nine cases 99 controls enrolled. Thirty-five percent...
Treatment options for carbapenem-resistant Enterobacteriaceae (CRE) infections are limited and CRE remain associated with high clinical failure mortality rates, particularly in vulnerable patient populations. A Phase 3, multinational, open-label, randomized controlled trial (TANGO II) was conducted from 2014 to 2017 evaluate the efficacy/safety of meropenem-vaborbactam monotherapy versus best available therapy (BAT) CRE.A total 77 patients confirmed/suspected infection (bacteremia,...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections. The intent of this document is to highlight practical in a concise format designed assist acute care hospitals implementing prioritizing their catheter-associated urinary tract infection (CAUTI) prevention efforts. Refer the Society Healthcare Epidemiology America/Infectious Diseases America “Compendium Strategies Prevent...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections (HAIs). The intent of this document is to highlight practical in a concise format designed assist acute care hospitals implementing prioritizing their surgical site infection (SSI) prevention efforts. This updates “Strategies Prevent Surgical Site Infections Acute Care Hospitals,” 2008. expert guidance sponsored by the Society Healthcare...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections. The intent of this document is to highlight practical in a concise format designed assist acute care hospitals implementing prioritizing their ventilator-associated pneumonia (VAP) prevention efforts. Refer the Society Healthcare Epidemiology America/Infectious Diseases America “Compendium Strategies Prevent Healthcare-Associated Infections”...
The β-lactamase inhibitor relebactam can restore imipenem activity against imipenem-nonsusceptible gram-negative pathogens. We evaluated imipenem/relebactam for treating infections.Randomized, controlled, double-blind, phase 3 trial. Hospitalized patients with hospital-acquired/ventilator-associated pneumonia, complicated intraabdominal infection, or urinary tract infection caused by (but colistin- and imipenem/relebactam-susceptible) pathogens were randomized 2:1 to 5-21 days...
Background. Colistin, originally abandoned due to high rates of nephrotoxicity, has been recently reintroduced activity against carbapenem-resistant Gram-negative organisms. Recent literature, largely obtained from outside the United States, suggests a lower rate nephrotoxicity than historically reported.
Preventable healthcare-associated infections (HAIs) occur in US hospitals. Preventing these is a national priority, with initiatives led by healthcare organizations, professional associations, government and accrediting agencies, legislators, regulators, payers, consumer advocacy groups. To assist acute care hospitals focusing prioritizing efforts to implement evidence-based practices for prevention of HAIs, the Society Healthcare Epidemiology America Infectious Diseases Standards Practice...
<h3>Importance</h3> Meropenem-vaborbactam is a combination carbapenem/beta-lactamase inhibitor and potential treatment for severe drug-resistant gram-negative infections. <h3>Objective</h3> To evaluate efficacy adverse events of meropenem-vaborbactam in complicated urinary tract infection (UTI), including acute pyelonephritis. <h3>Design, Setting, Participants</h3> Phase 3, multicenter, multinational, randomized clinical trial (TANGO I) conducted November 2014 to April 2016 enrolling...
ABSTRACT The emergence of multidrug-resistant (MDR) Klebsiella pneumoniae has resulted in a more frequent reliance on treatment using colistin. However, resistance to colistin (Col r ) is increasingly reported from clinical settings. genetic mechanisms that lead Col K. are not fully characterized. Using combination genome sequencing and transcriptional profiling by RNA (RNA-Seq) analysis, distinct were found among nine isolates. was related mutations three different genes strains, with...