Oon Tek Ng
A5041997002- Antibiotic Resistance in Bacteria
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Vibrio bacteria research studies
- HIV-related health complications and treatments
- Enterobacteriaceae and Cronobacter Research
- Antibiotics Pharmacokinetics and Efficacy
- Infection Control and Ventilation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Tuberculosis Research and Epidemiology
- Bacterial biofilms and quorum sensing
- Antimicrobial agents and applications
- Bacillus and Francisella bacterial research
- Poxvirus research and outbreaks
- COVID-19 epidemiological studies
- Mycobacterium research and diagnosis
- COVID-19 and Mental Health
- Pharmaceutical and Antibiotic Environmental Impacts
- Antimicrobial Peptides and Activities
- SARS-CoV-2 detection and testing
Tan Tock Seng Hospital
2016-2025
National Centre for Infectious Diseases
2014-2025
Nanyang Technological University
2017-2025
National University of Singapore
2013-2025
Sir Run Run Shaw Hospital
2023
Zhejiang University
2023
Singapore General Hospital
2012-2022
National University Hospital
2020-2022
Ministry of Health
2013-2022
Instituto Evandro Chagas
2022
This study documents results of SARS-CoV-2 polymerase chain reaction (PCR) testing environmental surfaces and personal protective equipment surrounding 3 COVID-19 patients in isolation rooms a Singapore hospital.
Abstract Understanding the particle size distribution in air and patterns of environmental contamination SARS-CoV-2 is essential for infection prevention policies. Here we screen surface samples from hospital rooms COVID-19 patients RNA. Environmental sampling conducted three airborne isolation (AIIRs) ICU 27 AIIRs general ward. 245 are collected. 56.7% have at least one contaminated. High touch shown ten (66.7%) out 15 first week illness, (20%) beyond illness ( p = 0.01, χ 2 test). Air...
Abstract In May 2019, we investigated monkeypox in a traveler from Nigeria to Singapore. The public health response included rapid identification of contacts, use quarantine, and postexposure smallpox vaccination. No secondary cases were identified. Countries should develop surveillance systems detect emerging infectious diseases globally.
BackgroundRapid identification of COVID-19 cases, which is crucial to outbreak containment efforts, challenging due the lack pathognomonic symptoms and in settings with limited capacity for specialized nucleic acid–based reverse transcription polymerase chain reaction (PCR) testing.
Key knowledge gaps remain in the understanding of viral dynamics and immune response Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection.We evaluated these characteristics established their association with clinical severity a prospective observational cohort study 100 patients PCR-confirmed SARS-CoV-2 infection (mean age, 46 years; 56% male; 38% comorbidities). samples (n = 74) were collected for culture, serum measurement IgM/IgG levels 30), plasma inflammatory cytokines...
Abstract We report a case of naturally acquired Plasmodium knowlesi in Singapore, malaria-free country. Diagnosis was confirmed by PCR with validated species-specific primers. In industrialized countries, free-ranging primates are potential source P. human infection. infection is differential diagnosis febrile illness Singapore.
Background The United States FDA approved an over-the-counter HIV self-test, to facilitate increased testing and earlier linkage care. We assessed the accuracy of self-testing by untrained participants compared healthcare worker (HCW) testing, participants' ability interpret sample results user-acceptability self-tests in Singapore. Methodology/Principal Findings A cross-sectional study, involving 200 known HIV-positive patients 794 unknown status at-risk was conducted. Participants (all...
Abstract The treatment of bacterial infections is hindered by the presence biofilms and metabolically inactive persisters. Here, we report synthesis an enantiomeric block co-beta-peptide, poly(amido-D-glucose)- -poly(beta-L-lysine), with high yield purity one-shot one-pot anionic-ring opening (co)polymerization. co-beta-peptide bactericidal against methicillin-resistant Staphylococcus aureus (MRSA), including replicating, biofilm persister cells, also disperses biomass. It active towards...
Abstract Understanding the particle size distribution in air and patterns of environmental contamination SARS-CoV-2 is essential for infection prevention policies. We aimed to detect surface study associated patient-level factors. 245 samples were collected from 30 airborne isolation rooms COVID-19 patients, sampling was conducted 3 rooms. Air detected PCR-positive particles sizes >4 µm 1-4 two rooms, which warrants further transmission potential SARS-CoV-2. 56.7% had at least one...
Carbapenem-resistant Gram-negative bacteria (GNB) are heading the list of pathogens for which antibiotics most critically needed. Many either unable to penetrate outer-membrane or excluded by efflux mechanisms. Here, we report a cationic block β-peptide (PAS8-b-PDM12) that reverses intrinsic antibiotic resistance in GNB two distinct mechanisms action. PAS8-b-PDM12 does not only compromise integrity bacterial outer-membrane, it also deactivates pump systems dissipating transmembrane...
Cationic polymers are promising antibacterial agents because bacteria have a low propensity to develop resistance against them, but they usually biocompatibility of their hydrophobic moieties. Herein, we report new biodegradable and biocompatible chitosan-derived cationic polymer, 2,6-diamino chitosan (2,6-DAC). 2,6-DAC shows excellent broad-spectrum antimicrobial activity with minimum inhibitory concentrations (MICs) 8–32 μg/mL clinically relevant multidrug-resistant (MDR) including...
Impact of the Delta variant and vaccination on SARS-CoV-2 transmission remains unclear. In Singapore, quarantine all close contacts, including entry exit PCR testing, provided opportunity to determine risk infection by compared other variants, vaccine efficacy against acquisition, symptomatic or severe COVID-19, factors associated with acquisition disease.
Assessing booster effectiveness of COVID-19 mRNA vaccine and inactivated SARS-CoV-2 over longer time intervals in response to any further variants is crucial determining optimal vaccination strategies.To determine levels protection against severe confirmed infection by types combinations boosters Singapore during the Omicron wave.This cohort study included residents aged 30 years or more vaccinated with either at least 2 doses vaccines (ie, Pfizer-BioNTech BNT162b2 Moderna mRNA-1273)...
Abstract Carbapenemase-producing Enterobacterales (CPE) infection control practices are based on the paradigm that detected carriers in hospital transmit to other patients who stay same ward. The role of plasmid-mediated transmission at population level remains largely unknown. In this retrospective cohort study over 4.7 years involving all multi-disciplinary public hospitals Singapore, we analysed 779 acquired CPE (1215 isolates) by clinical or surveillance cultures. 42.0% met putative...
Importance In September 2023, the Singapore Ministry of Health revised national personal protective equipment (PPE) guideline for health care personnel (HCP) attending to suspected or confirmed patients with COVID-19, recommending use N95 respirators alone. However, data on associations between PPE deescalation, staff COVID-19 incidence, and sustainability outcomes are limited. Objective To evaluate deescalation guidelines incidence environmental measure. Design, Setting, Participants This...
Since 2010, the incidence of carbapenem-resistant Enterobacteriaceae (CRE) has been increasing in Singapore. We analyzed clinical and molecular epidemiology CRE among adult inpatients Singapore.Quarterly unique subjects (per 100000 patient-days) with positive surveillance cultures for were estimated based on mandatory data submitted to National Public Health Laboratory by public hospitals between 2010 2015. CRE-positive prospectively recruited from 6 sector December 2013 April Subjects...
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The convergence of carbapenem-resistance and hypervirulence genes in Klebsiella pneumoniae has led to the emergence highly drug-resistant superbugs capable causing invasive disease. We analyzed 556 carbapenem-resistant K. isolates from patients Singapore hospitals during 2010-2015 discovered 18 7 also harbored features. All contained a closely related plasmid (pKPC2) harboring bla
Gram-negative bacteria cannot be easily eradicated by antibiotics and are a major source of recalcitrant infections indwelling medical devices. Among various device-associated infections, intravascular catheter infection is leading cause mortality. Prior approaches to surface modification, such as impregnation, hydrophilization, unstructured NO-releasing, etc., have failed achieve adequate infection-resistant coatings. We report precision-structured diblock copolymer brush (H(N)-b-S)...
Sewage-based surveillance is widely employed to understand the occurrence and distribution of antimicrobial resistance (AMR) in urban community. However, there are limited studies which investigated sewage different sources within The present study used metagenomics decipher AMR profiles five sources: local residence's source, animal migrant workers' clinical source , wastewater treatment plant influent. A core resistome ARGs was found across all samples, accounting for 81.4%-93.3% abundance...