Symeon Metallidis
A5056208413- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- COVID-19 and healthcare impacts
- Antibiotic Resistance in Bacteria
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- HIV/AIDS drug development and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory Support and Mechanisms
- Bacterial Identification and Susceptibility Testing
- Hepatitis C virus research
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Diabetes Treatment and Management
- HIV, Drug Use, Sexual Risk
- Antimicrobial Resistance in Staphylococcus
- Hepatitis Viruses Studies and Epidemiology
- Trauma and Emergency Care Studies
- Clostridium difficile and Clostridium perfringens research
- Cardiac, Anesthesia and Surgical Outcomes
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
AHEPA University Hospital
2015-2024
Aristotle University of Thessaloniki
2015-2024
National and Kapodistrian University of Athens
2020-2022
Papageorgiou General Hospital
2022
General Hospital Asklepieio Voulas
2022
Radboud University Nijmegen
2022
University of Patras
2022
Australian National University
2022
General Hospital of Athens G. Genimatas
2022
Thriasio General Hospital of Elefsina
2022
Emerging data indicate that complement and neutrophils contribute to the maladaptive immune response fuels hyperinflammation thrombotic microangiopathy, thereby increasing coronavirus 2019 (COVID-19) mortality. Here, we investigated how interacts with platelet/neutrophil extracellular traps (NETs)/thrombin axis, using COVID-19 specimens, cell-based inhibition studies, NET/human aortic endothelial cell (HAEC) cocultures. Increased plasma levels of NETs, tissue factor (TF) activity, sC5b-9...
Abstract Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative increased risk progression coronavirus disease 2019 (COVID-19) to respiratory failure. The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety anakinra, an IL-1α/β inhibitor, in 594 patients with COVID-19 at progressing failure as identified by plasma suPAR ≥6 ng ml −1 , 85.9% ( n = 510) whom were receiving dexamethasone. At day 28, adjusted...
Severe acute respiratory syndrome coronavirus 2 infection has evolved into a global pandemic. Low-dose colchicine combines anti-inflammatory action with favorable safety profile.To evaluate the effect of treatment on cardiac and inflammatory biomarkers clinical outcomes in patients hospitalized disease 2019 (COVID-19).In this prospective, open-label, randomized trial (the Greek Study Effects Colchicine COVID-19 Complications Prevention), 105 were 1:1 allocation from April 3 to 27, 2020,...
<h3>Importance</h3> Meropenem-vaborbactam is a combination carbapenem/beta-lactamase inhibitor and potential treatment for severe drug-resistant gram-negative infections. <h3>Objective</h3> To evaluate efficacy adverse events of meropenem-vaborbactam in complicated urinary tract infection (UTI), including acute pyelonephritis. <h3>Design, Setting, Participants</h3> Phase 3, multicenter, multinational, randomized clinical trial (TANGO I) conducted November 2014 to April 2016 enrolling...
It was studied if early suPAR-guided anakinra treatment can prevent severe respiratory failure (SRF) of COVID-19.A total 130 patients with suPAR ≥6 ng/ml were assigned to subcutaneous 100 mg once daily for 10 days. Primary outcome SRF incidence by day 14 defined as any ratio below 150 mmHg necessitating mechanical or non-invasive ventilation. Main secondary outcomes 30-day mortality and inflammatory mediators; 28-day WHO-CPS explored. Propensity-matched standard-of care comparators...
There is limited information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection clustering within families with children. We aimed to study the transmission dynamics of SARS-CoV-2 children in Greece. studied 23 family clusters disease 2019 (COVID-19). Infection was diagnosed by reverse-transcriptase polymerase chain reaction specimens. The level viral load categorized as high, moderate, or low based cycle threshold values. were 109 household members (66 adults and 43...
A significant proportion of people infected with SARS-CoV-2 report a new onset smell or taste loss. The duration the chemosensory impairment and predictive factors recovery are still unclear. We aimed to investigate prevalence, temporal course predictors in patients who suffered from varying disease severity. Consecutive adult diagnosed be via reverse-transcription–polymerase chain reaction (RT-PCR) at two coronavirus disease-2019 (COVID-19) Reference Hospitals were contacted complete survey...
Complement C3 activation contributes to COVID-19 pathology, and targeting has emerged as a promising therapeutic strategy. We provide interim data from ITHACA, the first randomized trial evaluating inhibitor, AMY-101, in severe (PaO2/FiO2 ≤ 300 mmHg). Patients received AMY-101 ( n = 16) or placebo 15) addition standard of care. was safe well tolerated. Compared (8 15, 53.3%), higher, albeit nonsignificant, proportion AMY-101–treated patients (13 16, 81.3%) were free supplemental oxygen at...
To highlight the clinical significance of carbapenem-resistant Klebsiella pneumoniae (CRKP) rectal colonization by examining risk factors for CRKP and subsequent bloodstream infection (BSI) in critically ill patients.Prospective study an intensive care unit (ICU) during a 39-month period. strains isolated from both blood cultures corresponding specimens (n=96) patients were screened PCR presence antibiotic resistance-associated genes. Molecular analyses conducted to investigate clonal...
Detection of SARS-CoV-2 in sewage has been employed by several researchers as an alternative early warning indicator virus spreading communities, covering both symptomatic and asymptomatic cases. A factor that can seriously mislead the quantitative measurement viral copies is adsorption fragments onto highly porous solids suspended wastewater, making them inaccessible. This depends not only on available amount solids, but also other dissolved chemicals which may influence capacity...
Most patients infected with SARS-CoV-2 (COVID-19) experience mild, non-specific symptoms, but many develop severe symptoms associated an excessive inflammatory response. Elevated plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) provide early warning progression to respiratory failure (SRF) or death, access suPAR testing may be limited. The Severe COvid Prediction Estimate (SCOPE) score, derived from circulating C-reactive protein, D- dimers, interleukin-6,...
Background: To date, evidence about sleep disturbances among post-COVID-19 patients is limited. This study aimed to evaluate quality after hospitalization due SARS-CoV-2 infection. Methods: In-person follow-up was conducted in with prior COVID-19 1(Τ1), 3(Τ2), and 6 (Τ3) months hospital discharge. Patients were asked complete questionnaires concerning quality: the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Athens Insomnia (AIS), Fatigue Severity (FSS), Stop-BANG...
Abstract Background Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes transitions associated response anakinra (human interleukin 1 receptor antagonist) in participants the SAVE-MORE trial. Methods Adult hospitalized radiological findings PCR-confirmed severe pneumonia caused by SARS-CoV-2 plasma-soluble urokinase plasminogen activator levels ≥ 6 ng/ml trial (NCT04680949) were characterized at...
People living with human immunodeficiency virus (PLHIV) are at increased risk of atherosclerotic cardiovascular disease (ASCVD) and prone to statin-related adverse events from drug–drug interactions certain antiretroviral regimens. This study sought evaluate the efficacy safety evolocumab in dyslipidemic PLHIV. BEIJERINCK (EvolocumaB Effect on LDL-C Lowering SubJEcts Human Immunodeficiency VirRus INcreased Cardiovascular RisK) is a randomized, double-blind, multinational trial comparing...
The trajectory from moderate and severe COVID-19 into acute respiratory distress syndrome (ARDS) necessitating mechanical ventilation (MV) is a field of active research. We determined serum levels within 24 h presentation 20 different sets mediators (calprotectin, pro- anti-inflammatory cytokines, interferons) patients with at stages severity (asymptomatic, moderate, ARDS/MV). primary endpoint was to define associations critical illness, the secondary identify pathways associated mortality....
Background Although combined antiretroviral therapy has substantially improved the prognosis of people living with HIV (PLHIV), mortality remains higher compared to general population, mainly due prevalence non-HIV-related comorbidities, including cardiovascular diseases (CVD). We assessed CVD risk and its contributing factors in adult PLHIV versus population controls Greece. Settings Cross-sectional comparison (Athens-Multicenter-AIDS-Cohort-Study; AMACS) (National health examination...
During the COVID-19 pandemic, wastewater-based epidemiology (WBE) has been engaged to complement medical surveillance and in some cases also act as an early diagnosis indicator of viral spreading community. Most efforts worldwide by scientific community commercial companies focus on formulation protocols for SARS-CoV-2 analysis wastewater approaches addressing quantitative relationship between WBE are lacking. In present study, a mathematical model is developed which uses input number daily...
Chronic liver disease is one of the main causes morbidity and mortality in people living with HIV (PLWH). The increasing life expectancy PLWH, effective treatment for viral hepatitis, Western dietary patterns as well adverse effects antiretroviral therapy (ART) have rendered metabolic dysfunction-associated steatotic (MASLD) most common chronic PLWH. risk factors MASLD PLWH include traditional additional virus-specific factors, including ART. management patients suffering from often...
Abstract Emerging data indicate that complement and neutrophils are involved in the maladaptive host immune response fuels hyper-inflammation thrombotic microangiopathy increasing mortality rate coronavirus disease 2019 (COVID-19). Here, we investigated interaction between platelet/neutrophil extracellular traps (NETs)/thrombin axis, using COVID-19 clinical samples, cell-based inhibition studies NETs/human aortic endothelial cell (HAEC) co-cultures. Increased plasma levels of NETs, TF...
Recent publications on the probable role of heparin-binding protein (HBP) as a biomarker in sepsis prompted us to investigate its diagnostic and prognostic performance severe COVID-19. HBP IL-6 were measured by immunoassays at admission day 7 178 patients with pneumonia SARS-CoV-2. Patients classified into non-sepsis per Sepsis-3 definitions followed up for development respiratory failure (SRF) outcome. Results confirmed multivariate analyses. was significantly higher having negatively...