A5006520391- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Hepatitis C virus research
- Crystallography and molecular interactions
- HIV, Drug Use, Sexual Risk
- Vector-borne infectious diseases
- Infectious Diseases and Tuberculosis
- HIV-related health complications and treatments
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Tuberculosis Research and Epidemiology
- Research on Leishmaniasis Studies
- Antifungal resistance and susceptibility
- Malaria Research and Control
- Hepatitis Viruses Studies and Epidemiology
- Cytomegalovirus and herpesvirus research
- Travel-related health issues
- Electromagnetic Fields and Biological Effects
- Business and Management Studies
Hospital Garcia de Orta
2018-2025
University of Lisbon
2024
Infraestruturas de Portugal (Portugal)
2024
Centro Hospitalar de Lisboa Central
2021
Hospitais da Universidade de Coimbra
2007-2017
Universidade Nova de Lisboa
2012
University of Coimbra
2007-2008
People living with human immunodeficiency virus (PLHIV) are at increased risk of atherosclerotic cardiovascular disease (ASCVD) and prone to statin-related adverse events from drug–drug interactions certain antiretroviral regimens. This study sought evaluate the efficacy safety evolocumab in dyslipidemic PLHIV. BEIJERINCK (EvolocumaB Effect on LDL-C Lowering SubJEcts Human Immunodeficiency VirRus INcreased Cardiovascular RisK) is a randomized, double-blind, multinational trial comparing...
Background/Objectives: The timely initiation of antiretroviral therapy (ART) in persons living with HIV (PLWH) improves clinical outcomes. However, ART commencement is often delayed. Portugal, which has one the highest new diagnosis rates within European Union, limited available data. Evidence from 2017-2018 suggests that average time to exceeds recommendations for optimal benefits. This study aimed assess number days first hospital appointment among newly diagnosed PLWH Portugal between...
Introduction HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with MSM population newly diagnosed Portugal between 2014 and 2019. Methods included 391 HIV-1 Men who have Sex (MSM), from BESTHOPE project, 17 countrywide Portuguese hospitals. The data clinical socio-behavioral questionnaires viral genomic sequence obtained drug resistance test before starting antiretrovirals (ARVs). subtypes epidemiological surveillance mutations were...
Fifteen years after the initial detection of Rickettsia slovaca in ticks Portugal, 3 autochthonous cases R. infection were diagnosed humans. All patients had an eschar on scalp and lymphadenopathy; 2 facial edema. was confirmed by serologic testing, culture, PCR.
Mediterranean spotted fever (MSF) is the most prevalent zoonosis in Portugal. To characterize it's evolution between 1989 and 2012, authors reviewed cases diagnosed at their unit during this period.Review of clinical records patients with MSF diagnosis, 2012.Data from 250 was included, 54% male. Mean age diagnosis 58 years (11-92). annual incidence 10 cases, clear summer predominance. Most patients, 78% lived rural areas, 34% had contact dogs 10% noticed tick bite. common symptoms were:...
Glecaprevir/pibrentasvir is approved for treating chronic hepatitis C virus (HCV) genotypes (GT) 1-6. We evaluated real-world effectiveness, safety, and patient-reported outcomes of glecaprevir/pibrentasvir in underserved patient populations, focusing on persons who use drugs infected with HCV.Data were pooled from nine countries (13 November 2017-31 January 2020). Patients had HCV GT1-6, or without compensated cirrhosis, prior treatment received consistent local label at their physician's...
A cross-sectional study was conducted in 151 (71.6%) of 211 male inmates a regional Portuguese prison order to establish the seroprevalence for viral hepatitis (HAV, HBV, HCV), human immunodeficiency virus (HIV), syphilis and herpes simplex (HSV-1 HSV-2) analyze some psychosocial criminal characteristics. Mean age 34 years. Anti-HAV positive 69.5% (n = 105) 34.4% 52) anti-HCV. One (0.7%) person had HBsAg 29 (19.2%) laboratory markers past HBV infection. Non-immune were 40.4% 61). Syphilis...
The cytomegalovirus (CMV) disease spectrum is very wide, with symptomatic infections being rare in immunocompetent hosts. We present the case of a 31-year-old man diagnosed CMV gastritis context primary infection. most important laboratory abnormalities leading to diagnosis were: elevation liver enzymes (3–4× upper limit normal), thrombocytopenia (133 G/L), lymphocytosis (55%–4.2 G/L) activated lymphocytes, IgM positive (negative IgG), viral load 5700 copies/mL (real-time PCR); autoimmunity...
Introduction: Dengue virus (DENV) is the arbovirus with widest impact on human health. In Africa in general, and Angola particular, epidemiology public health of DENV far from clear. However, rapid population growth, unplanned urbanization, increased international travel, presence major vector (Aedes aegypti) country suggest that transmission may occur. Methodology: parallel to occurrence a dengue outbreak affecting capital Angola, between March July 2013 four Portuguese institutions...
Miltefosine is the first effective oral drug against visceral leishmaniasis. However, there are few data about its role increasing problem of HIV-associated It necessary to establish a treatment and secondary prophylaxis approach with miltefosine in this population, particularly for those whom standard was unsuccessful. We report our experience 5 HIV-infected patients. used relapse treatments (50 mg, b.i.d.) 3 patients as maintenance therapy times/week) all them. discontinued after full...
Integrase strand transfer inhibitor-based regimens are recommended for first-line therapy in human immunodeficiency virus type 2 (HIV-2). Nonetheless, dolutegravir (DTG) clinical trial data lacking.We conducted a phase 2, single-arm, open-label to evaluate the safety and efficacy of triple regimen that included DTG persons with HIV-2 (PWHIV-2) Portugal. Treatment-naive adults receive combination nucleoside reverse transcriptase inhibitors (NRTIs). Treatment was evaluated by proportion...
Information about pan-genotypic treatments for hepatitis in Portugal is scarce. We aimed to evaluate the effectiveness and safety of glecaprevir plus pibrentasvir (GLE/PIB) treatment C virus (HCV) infection real-world clinical practice.
The monIT project provides public information on population exposure to electromagnetic fields (EMF) from mobile communication systems in Portugal. monitoring system is based a network of autonomous remote probing stations, and also an extensive EMF sounding program, both carried out areas across the country. Measured results are automatically uploaded Web site for dissemination (http://www.lx.it.pt/monit), which includes other relevant about general public. This paper describes project's...
Zika virus is an emerging arbovirus transmitted by Aedes sp. mosquitoes like the Dengue and Chikungunya viruses. was until recently considered a mild pathogenic mosquito-borne flavivirus with very few reported benign human infections. In 2007, epidemic in Micronesia initiated turnover epidemiological history of more recently, potential association congenital microcephaly cases Brazil 2015, still under investigation, led World Health Organization (WHO) to declare Public Emergency...
HIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots subtype diversity deepens complexity HIV-1/AIDS control. The already high Portugal seems to be increasing due infections sub-subtype A1 virus. We performed phylogenetic analysis 65 sequences newly obtained from 14 Portuguese hospitals 425 closely related database sequences. 80% isolates gathered a main clade (MA1). Six clusters were identified MA1, encompassing...
A cross-sectional study was conducted in 151 (71.6%) of 211 male inmates a regional Portuguese prison order to establish the seroprevalence for viral hepatitis (HAV, HBV, HCV), human immunodeficiency virus (HIV), syphilis and herpes simplex (HSV-1 HSV-2) analyze some psychosocial criminal characteristics. Mean age 34 years. Anti-HAV positive 69.5% (n = 105) 34.4% 52) anti-HCV. One (0.7%) person had HBsAg 29 (19.2%) laboratory markers past HBV infection. Non-immune were 40.4% 61). Syphilis...
Late human immunodeficiency virus (HIV) diagnosis has been associated with missed opportunities for earlier diagnosis. We conducted a retrospective, longitudinal, single-centre cohort study evaluating these and their clinical repercussions in adults new HIV or who were drug-naïve, attended our Infectious Diseases Department between 2018 2023. assessed the two years prior to after last negative test. compared laboratorial data from individuals without opportunities. The primary outcome...
Histoplasmosis is a systemic mycosis caused by Histoplasma capsulatum. Rare in Europe but endemic some regions of Brazil, United States, Africa and Asia. Most the cases are asymptomatic. Disseminated form defined presence an extra-pulmonary focus, particularly associated with immunosuppression. We report case unilateral persisted tonsillar ulceration, immunocompetent Portuguese host, as manifestation disseminated African histoplasmosis 45 years later after living 3 Africa.
To describe and analyze transmitted drug resistance (TDR) between 2014 2019 in newly infected patients with HIV-1 Portugal to characterize its transmission networks.Clinical, socioepidemiological, risk behavior data were collected from 820 diagnosed September December 2019. The sequences obtained testing used for subtyping, TDR determination, cluster (TC) analyses.In Portugal, the overall prevalence of was 11.0%. presented a decreasing trend 16.7% 9.2% 2016 (p for-trend = 0.114)....
We report a case of spondylodiscitis caused by multiresistant Serratia marcescens in cirrhotic patient who had several bacteremias after the placement transjugular intrahepatic portosystemic shunt (TIPS) device. concluded that an endovascular stent can not be removed makes management recurrent bacteremia difficult. Furthermore, back pain due to is indicative spondylodiscitis. aggressive pathogen, causing spinal infection.