A5076573837- Hepatitis Viruses Studies and Epidemiology
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- HIV/AIDS Research and Interventions
- Liver Disease and Transplantation
- Infectious Encephalopathies and Encephalitis
- Liver Disease Diagnosis and Treatment
- Infectious Disease Case Reports and Treatments
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Long-Term Effects of COVID-19
- Toxoplasma gondii Research Studies
- HIV, Drug Use, Sexual Risk
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Diagnosis and treatment of tuberculosis
- Clostridium difficile and Clostridium perfringens research
- Bacillus and Francisella bacterial research
- Neurological Complications and Syndromes
Centro Hospitalar de Lisboa Central
2015-2025
Hospital Curry Cabral
2013-2024
Universidade Nova de Lisboa
2024
University of Lisbon
2022-2023
Fundação de Apoio à Universidade Federal de São Paulo
2006
ObjectiveTo characterize the profile of non-AIDS-related comorbidities (NARC) in older HIV-1-infected population and to explore factors associated with multiple NARC.MethodsThis was a multicentre, cross-sectional study including patients aged ≥50 years, who were virologically suppressed had been on stable antiretroviral therapy (ART) regimen for at least 6 months. A regression model explored association between demographic clinical variables number NARC.ResultsOverall, 401 enrolled. The mean...
Monkeypox, a neglected and re-emergent zoonotic disease caused by monkeypox virus (MPXV) infection, has been endemic in Central Western Africa for decades. More recently, an outbreak spread to global level, occurring sites with no previous reported cases being clustered among men who have sex men, suggesting new modes of transmission. There is urgent need research better understanding the genomic evolution changing epidemiology Orthopoxvirus group. Our work aimed characterize clinical...
This case emphasizes the importance of considering tuberculosis (TB) in differential diagnosis complex kidney imaging findings. We report a 43-year-old male patient from India who presented with five-day history fever and vomiting. Laboratory results revealed metabolic acidosis, anemia, acute injury, elevated inflammatory markers. A computed tomography urogram demonstrated significant findings: minimal parenchymal remnants left replaced by caliectasis, ureteral pyelitis, retroperitoneal...
Integrase strand transfer inhibitor-based regimens are recommended for first-line therapy in human immunodeficiency virus type 2 (HIV-2). Nonetheless, dolutegravir (DTG) clinical trial data lacking.We conducted a phase 2, single-arm, open-label to evaluate the safety and efficacy of triple regimen that included DTG persons with HIV-2 (PWHIV-2) Portugal. Treatment-naive adults receive combination nucleoside reverse transcriptase inhibitors (NRTIs). Treatment was evaluated by proportion...
Information about pan-genotypic treatments for hepatitis in Portugal is scarce. We aimed to evaluate the effectiveness and safety of glecaprevir plus pibrentasvir (GLE/PIB) treatment C virus (HCV) infection real-world clinical practice.
An outbreak of hepatitis A is ongoing in Portugal, with 71 confirmed cases from 7 October 2023 to 24 April 2024. Most are male, aged 18-44 years, many identifying as men who have sex (MSM) and reported suspected sexual transmission. Phylogenetic analysis identified the subgenotype IA, VRD 521-2016 strain, last observed an MSM-associated multi-country 2016 2018. We wish alert colleagues other countries investigate potential similar spread.
Background: Case report, in a patient with history of diabetes and hypertension, treated metformin, gliclazide, enalapril + hydrochlorothiazide, amlodipine, aspirin diazepam, recently medicated for gouty crisis colchicine clonixin without improvement. Believing it could help the treatment symptoms he took about 1.5 L artichoke infusion (Cynara cardunculus). He felt better did agriculture work but developed distal muscle pain, severe anemia, standard biochemical liver cholestasis, increase...
We present a case of structural and functional changes compatible with didanosine retinopathy in patient who also developed non-cirrhotic portal hypertension.
Introduction: Clostridioides difficile is the main cause of healthcare-associated diarrhea in Europe and North America. The aim this study was to characterize epidemiology clinical burden infection among hospitalized patients Portugal.Material Methods: Retrospective conducted six public hospital centers Portugal. All primary episodes related recurrences occurring 2017, as well developing two eight weeks after last episode diagnosed that year, were documented. National Reference Laboratory...
Hepatitis E in industrialized countries is mainly associated with genotype 3 hepatitis virus (HEV) and normally causes a sporadic self-limiting disease immunocompetent individuals. Unlike 3, genotypes 1 2 circulate developing countries, produce severe occur the epidemic form. occurring travellers returning from endemic areas not novel epidemiological occurrence, however vast majority of cases remain to be genetically studied. The present study describes two acute that required...
Background: Although endemic in West Africa, HIV-2 infection dissemination is limited to about 1.2 million people worldwide.However, the prevalence of Portugal disproportionately high, similarly other countries with strong socioeconomic ties African former colonies.Due intrinsic resistance non-nucleoside reverse transcriptase inhibitors (non-NRTIs) and enfuvirtide, along reduced susceptibility several protease (PI), antiretroviral therapy (ART) relies on a regimen containing two NRTIs...
Hepatitis E virus genotype 3 infections are normally asymptomatic in immunocompetent individuals. Symptomatic cases of acute icteric hepatitis seldom observed among women, younger men and children but particularly seen middle-aged/elderly men. We report a case severe caused by an 40-year-old woman that required prolonged hospitalization. Her medical history included autoimmune background, namely atrophic gastritis Graves’ disease. She presented extensive hepatic necrosis as revealed the high...
Abstract Background and Aims : Risk of liver-related morbidity mortality is not eliminated in cirrhotic patients following direct-acting antiviral treatment. This study aimed to assess virologic clinical outcomes among chronic hepatitis C who received sofosbuvir (SOF)-based regimens. Methods Non-interventional, multicenter,retrospective, single-cohort 1,724 started treatment with regimens between February 2015 August 2016. SVR12, liver fibrosis, progression disease risks scores were...
With accelerated ageing of population in developing countries AD will be a major problem for health care services. It is not clear how limited resources meet the needs growing people, but it that simpler methods follow up and determination response to available therapy needed. The drugs may vary according ethnicity, most studies were undertaken Caucasian populations, while mostly an ethnically mixed one. Presentation description demographic characteristics large followed at...
Immunosuppression (IS) is considered a risk factor for severe COVID-19. It remains unclear if solid organ transplantation (SOT) affects its presentation or outcome. We aimed to describe the clinical course of SOT recipients hospitalized due SARS-CoV-2 infection. Hospitalizations COVID-19 in Infectious Diseases Department from March 2020 January 2021 were reviewed, and selected. Seventeen patients (pts) included, 13 which male, with median age 58 years. Transplanted organs kidney (n=11, 2...