A5102793180- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Impact and Responses
- Hepatitis B Virus Studies
- HIV, Drug Use, Sexual Risk
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Antifungal resistance and susceptibility
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer, Lipids, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Fungal Infections and Studies
- Viral-associated cancers and disorders
- Research on Leishmaniasis Studies
- Dermatological and COVID-19 studies
- Biotechnology and Related Fields
- Biochemical and Molecular Research
- Antimicrobial Resistance in Staphylococcus
- Hepatitis Viruses Studies and Epidemiology
Hospital de Egas Moniz
2013-2025
Centro Hospitalar de Lisboa Ocidental
2009-2022
ObjectiveTo characterize the profile of non-AIDS-related comorbidities (NARC) in older HIV-1-infected population and to explore factors associated with multiple NARC.MethodsThis was a multicentre, cross-sectional study including patients aged ≥50 years, who were virologically suppressed had been on stable antiretroviral therapy (ART) regimen for at least 6 months. A regression model explored association between demographic clinical variables number NARC.ResultsOverall, 401 enrolled. The mean...
Human immunodeficiency virus type 2 (HIV-2) is an attenuated retroviral infection characterized by specific natural susceptibility to antiretroviral drugs and acquired resistance profiles. Based on the latest knowledge of phenotypic data clinical follow-up, HIV-2 interpretation rules have been updated implemented in a freely available analysis tool.
To characterize the HIV-2 integrase gene polymorphisms and pathways to resistance of patients failing a raltegravir-containing regimen, we studied 63 strand transfer inhibitors (INSTI)-naïve patients, 10 heavily pretreated exhibiting virological failure while receiving salvage regimen. All were infected by group A. 61.4% residues conserved, including catalytic motif residues. No INSTI-major mutations detected in virus population from naïve but two amino acids that are secondary INSTIs HIV-1...
Introduction First antiretroviral therapy (ART) is often switched to simpler, more potent or better tolerated regimens [ 1 , 2 ]. Although discontinuation rates are frequently studied, the durability of rarely approached. Materials and Methods Retrospective study with following objectives: analyze first ART schemes their in naive patients chronic HIV‐1 infections, evaluate factors influencing change, second‐line consequent virologic immunologic responses. Patients had follow‐ups a Central...
Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by the newly discovered severe acute respiratory syndrome coronavirus 2. Remdesivir (RDV) and corticosteroids are used mainly in COVID-19 patients with failure. The main objective of study was to assess effectiveness remdesivir without treatment patients. We conducted prospective observational study, including adult consecutively hospitalized confirmed Patients were divided according strategy: RDV alone versus...
Undiagnosed HIV-1 patients still account for 25% of worldwide HIV patients. Studying late presenters (LPs) care may help to identify characteristics such The present study aims factors associated with presentation and advanced disease based on a population followed in Portuguese hospital between 1984 2017. Sociodemographic clinical data from infected aged 18 years older, Egas Moniz Hospital, Portugal were collected. Of the 907 included this study, 68.7% males median age was 37 (interquartile...
OBJECTIVE To analyze the direct medical costs of HIV/AIDS in Portugal from perspective National Health Service. METHODS A retrospective analysis records was conducted for 150 patients five specialized centers 2008. Data on utilization resources during 12 months and patients’ characteristics were collected. unit cost applied to each care component using official sources accounting data Service hospitals. RESULTS The average treatment 14,277 €/patient/year. main cost-driver antiretroviral (€...
Despite a decreasing mortality and morbidity in treated HIV-1 patients, highly active antiretroviral treatment (HAART) can still fail due to the development of drug resistance. Especially, multidrug-resistant viruses pose threat efficient therapy. We studied changing prevalence multidrug resistance (MDR) over time cohort HIV-1-infected patients Portugal. used data 8065 followed from July 2001 up April 2012 22 hospitals located MDR at specific date sampling was defined as no more than one...
This study is focused on the prevalent NS5 coding region resistance-associated substitutions (RASs) in DAA-naive genotype (GT)1 HCV-infected patients and their potential impact success rates. Plasma RNA from 81 GT1 was extracted prior to an in-house nested RT-PCR of region, which followed by Sanger population sequencing. NS5A RASs were present 28.4% (23/81) all GT1-infected with 9.9% (8/81) having Y93C/H mutation. NS5B showed a prevalence 14.8% (12/81) only detected GT1b. Overall 38.3%...
Introduction Late HIV diagnosis is common and associated with an increased risk of clinical progression, blunted immune response on antiretroviral (ARV) therapy higher drug toxicity. Across Europe, more than a third patients are diagnosed late consequently delay medical care. European Consensus definition group identify as presentation (LP) persons, presenting for care, CD4 count below 350 cell/mm 3 or AIDS‐defining event, regardless cell count. Additionally, advanced disease (AD) defined by...
Introdução: A leishmaniose visceral é uma infeção disseminada endémica, considerada a terceira parasitária oportunista mais frequente na Europa. É prevalente nos doentes co-infetados por vírus da imunodeficiência humana, em que acarreta um grande desafio terapêutico pelo risco acrescido de recaída. O objetivo do estudo caraterização população co-infetada e eficácia dos esquemas terapêuticos.Material Métodos: Estudo retrospetivo amostra seleccionada todos os com humana internados num período...
Introduction: In late 2014, Portugal implemented a national program for the treatment of patients with chronic hepatitis C directacting antiviral agents. This has made one first European countries to implement structured measure eliminate this serious public health problem. The aim study was assess effectiveness direct-acting therapy in virus infection.Material and Methods: A retrospective observational conducted at Centro Hospitalar de Lisboa Ocidental on online platform from December 2014...
Hepatitis C constitutes a major public health burden. In Portugal, the prevalence is estimated at 1-1.5% (1). Of these, only 30% are presumed to be diagnosed, which reveals that most infections go unknown. The objective of this study identify age-range distribution HCV diagnosis and high-prevalence birth groups could targeted for screening, as strategy increase patients who would benefit from treatment.Retrospective observational cohort chronic HCV-infected HIV co-infected followed an...
It is well established that HIV patients are at high risk of opportunistic infections (OI), like the ones caused by Pneumocystis jirovecii, a worldwide pathogen implicated in interstitial pneumonia (PcP). We present case newly diagnosed HIV-1 patient with multiple OI, including persistent form PcP, an invasive aspergillosis (IA), cytomegalovirus and Mycobacterium xenopi lung infection. describe combination laboratorial screening, surgery antimicrobial therapy were crucial for recovery.
Cirrhosis secondary to HCV infection is expected peak in the next decade, particularly HIV co-infected subgroup and has become a leading cause of morbidity among these individuals. Efforts must be done estimate risk liver decompensation (LD) short term, order define appropriate time for treatment.Retrospective observational cohort study aimed assess LD group HIV/HCV patients diagnosed past 23 years central hospital Lisbon.(1) advanced fibrosis ≥F3; (2) treatment naïve or without sustained...
Mycobacterium chelonae can cause chronic skin, soft-tissue or bone infections. and is often associated with the immunocompromised state.We describe a case of 58-year-old male patient myasthenia gravis, chronically immunosuppressed, four month progression growing erythematous, nodular hard cutaneous lesions in left forearm, leg foot. He was receiving immunoglobulin every weeks (2 g/kg) prednisolone 25 mg/day had an important previous history several opportunistic infections while he...
Direct-acting antiviral drugs (DAAs) have recently changed the paradigm of hepatitis C therapy, significantly improving treatment response rates, patient life expectancy and quality life. In Portugal, sofosbuvir (SOF) SOF/ledipasvir (SOF/LDV) were fully reimbursed by National Health System since early 2015 generalized use interferon-free DAA based regimens became current practice. During 2016, remaining DAAs sequentially added covered same health access policy. The Portuguese Study Group...
The decision to start hepatitis C virus (HCV) treatment and its timing remains controversial. As new regimens are approved, it is essential identify patients eligible for each regimen in a timed tailored approach. This study aims the reasons defer of chronic infection both HCV HCV/HIV infected patients.Retrospective observational cohort chronically with or without HIV infection, followed an infectious disease clinic Lisbon. Demographic, epidemiological, clinical, immunologic virologic data...