A5062914904- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- HIV, Drug Use, Sexual Risk
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Neurological disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
- Parkinson's Disease Mechanisms and Treatments
- Reproductive Health and Contraception
- Glycosylation and Glycoproteins Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Technology Use by Older Adults
- Cutaneous Melanoma Detection and Management
- Big Data and Business Intelligence
- Renal Transplantation Outcomes and Treatments
- Blood groups and transfusion
- Context-Aware Activity Recognition Systems
- Systemic Lupus Erythematosus Research
- Balance, Gait, and Falls Prevention
Centro Hospitalar do Porto
2013-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2025
Hospital de Santo António
1997-2025
Universidade do Porto
2017-2024
Eastern Virginia Medical School
2024
Fraunhofer Portugal Research
2012-2023
Hospital de São João
1997-2019
Instituto Português de Oncologia Francisco Gentil
2018
McGill University
2017
University of Minho
2016
The nature of the immune responses associated with COVID-19 pathogenesis and disease severity, as well breadth vaccine coverage duration immunity, is still unclear. Given unpredictability for developing a severe/complicated disease, there an urgent need in field predictive biomarkers COVID-19. We have analyzed IgG Fc N-glycan traits 82 SARS-CoV-2+ unvaccinated patients, at diagnosis, by nano-LC-ESI-MS. determined impact glyco-variations induction NK cells activation, further evaluating...
ObjectiveTo characterize the profile of non-AIDS-related comorbidities (NARC) in older HIV-1-infected population and to explore factors associated with multiple NARC.MethodsThis was a multicentre, cross-sectional study including patients aged ≥50 years, who were virologically suppressed had been on stable antiretroviral therapy (ART) regimen for at least 6 months. A regression model explored association between demographic clinical variables number NARC.ResultsOverall, 401 enrolled. The mean...
Pediatric appendicular bone sarcomas, including osteosarcoma and Ewing's sarcoma, are rare but aggressive malignancies that have a profound impact on survival, physical function, quality of life (QoL). Treatment options usually involve either limb-salvage surgery (LSS) or amputation (AMP), although evidence about outcomes among these approaches is still limited. A retrospective cohort study was conducted involving pediatric cases treated for sarcomas between 2000 2021 at the Instituto...
Introdução: A gravidez na adolescência é um evento de alta complexidade que não só envolve uma gama fatores biológicos, mas também sociais e econômicos. Objetivo: compreender como a interfere escolaridade da gestante dentro das escolas. Método: Trata-se relato experiência realizado por estudantes medicina do segundo período Faculdade Medicina Teresópolis Centro Universitário Serra dos Órgãos. Destacou-se pela abordagem cuidadosa temas puberdade, educação sexual, transmissão Infecção Sexual...
Objetivo: O objetivo central deste estudo é revisar a literatura científica sobre fisiopatologia do Diabetes Mellitus (DM) e os mecanismos subjacentes às complicações maternas associadas. Metodologia: Esta pesquisa uma revisão sistemática voltada para compreensão dos aspectos essenciais suas maternas. A investigação foi guiada pela pergunta: "Quais são principais que levam no Mellitus, quais as evidências científicas suportam estas descobertas?" Para responder esta questão, realizamos buscas...
Abstract Introduction Stigma and discrimination against people living with human immunodeficiency virus (PLHIV) within healthcare settings remain significant barriers to effective care. Stigmatizing attitudes persist among professionals, potentially undermining care quality. This study aimed assess HIV‐related knowledge professionals in Portugal, focusing on identifying factors associated stigma. Methods was part of a European survey by the Centre for Disease Prevention Control (ECDC) AIDS...
Introduction HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with MSM population newly diagnosed Portugal between 2014 and 2019. Methods included 391 HIV-1 Men who have Sex (MSM), from BESTHOPE project, 17 countrywide Portuguese hospitals. The data clinical socio-behavioral questionnaires viral genomic sequence obtained drug resistance test before starting antiretrovirals (ARVs). subtypes epidemiological surveillance mutations were...
This paper describes the development, deployment and trial results from 9 volunteers using eCAALYX system. The system is an ambient assisted living telemonitoring aimed at older adults suffering with co-morbidity. Described a raw account of challenges that exist in bringing Telemedicine laboratory to real-world implementation for usability, functionality reliability.
This paper presents REMPARK system, a novel approach to deal with Parkinson's Disease (PD). system comprises two closed loops of actuation onto PD. The first loop consists in wearable that, based on belt-worn movement sensor, detects alterations that activate an auditory cueing controlled by smartphone order improve patient's gait. sensor analyzes through real-time learning algorithms were developed the basis database previously collected from 93 PD patients. second disease management data...
CONTEXT: Software estimation is a vital yet challenging project management activity. Various methods, from empirical to algorithmic, have been developed fit different development contexts, plan-driven agile. Recently, machine learning techniques shown potential in this realm but are still underexplored, especially for individual task estimation. OBJECTIVES: We investigate the use of predicting effort and duration software projects assess their applicability effectiveness production...
Cytomegalovirus (CMV) infection in healthy adults is usually asymptomatic or causes a mild mononucleosis syndrome, while severe infections are rare immunocompetent patients and poorly documented. When described, gastrointestinal tract the central nervous systems most frequent sites of CMV infection. Lung disease can occur, but it's rare. A 29 years old man presenting with 2-weeks history fever, headache, malaise, dry non-productive cough thoracic pleuritic pain, without improvement after...
Parkinson's disease is one of the most common neurodegenerative disorders central nervous system that affects elderly.There are four main symptoms: tremors, rigidity, bradykinesia (slow movements) and posture instability.Nowadays any type diagnose for this disorder done through observation by a health care professional specialized in area.Therefore it necessary method simple efficient professionals general clinic to use so they can have some grounded backup decide forward possible patient...
ABSTRACT A large variation in the severity of disease symptoms is one key open questions COVID-19 pandemics. The fact that only a small subset people infected with SARS-CoV-2 develop severe suggests there have to be some predisposing factors, but biomarkers reliably predict not been found so far. Since overactivation immune system implicated form and IgG glycosylation known involved regulation different processes, we evaluated association inter-individual N-glycome composition COVID-19....
BACKGROUND: Recipients of renal transplantation (RT) exhibit disturbances serum lipids and apoproteins that may contribute to their cardiovascular morbidity mortality. In our transplant department the hypercholesterolaemia prevalence at first fifth year RT is 70.0% 81.2%, respectively. Lipid-lowering therapy has been utilized in many Transplant Units. The aim study was evaluate post-RT hyperlipidaemia control with simvastatin or fish oil. METHODS: Forty-three patients (26 men 17 women)...
Summary Little data are available on renal toxicity exerted by direct‐acting antivirals ( DAA s) in real life. The aim of this study was to assess the impact against hepatitis C virus infection currently used Spain and Portugal estimated glomerular filtration rate eGFR ) clinical practise. From an international, prospective multicohort study, patients treated with s for at least 12 weeks ≥30 mL/min per 1.73 m 2 baseline were selected. determined using CKD ‐ EPI formula. A total 1131...
HIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots subtype diversity deepens complexity HIV-1/AIDS control. The already high Portugal seems to be increasing due infections sub-subtype A1 virus. We performed phylogenetic analysis 65 sequences newly obtained from 14 Portuguese hospitals 425 closely related database sequences. 80% isolates gathered a main clade (MA1). Six clusters were identified MA1, encompassing...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder, seen most often in young adults and children, triggered by tumors or infections. We report a case of cryptococcal meningitis patient with sarcoidosis, presenting prominent neuropsychiatric symptoms, electroencephalographic features positive anti-NMDAR antibodies the cerebrospinal fluid, raising hypothesis infectious immune-mediated mechanism triggering production antibodies. Since potentially fatal has...
Adherence to Highly Active Antiretroviral Therapy (HAART) is the main prognostic factor associated with HIV disease progression and death. The aim was evaluate effectiveness of a psycho-educational program promote adherence HAART in patients. A longitudinal study (n=102) over 9 months an Infectious Diseases Hospital carried out. measured standardized scales values viral load. Two groups were defined: adherents non-adherents. In latter, implemented 6 later HAART. Knowledge about infection,...
To describe and analyze transmitted drug resistance (TDR) between 2014 2019 in newly infected patients with HIV-1 Portugal to characterize its transmission networks.Clinical, socioepidemiological, risk behavior data were collected from 820 diagnosed September December 2019. The sequences obtained testing used for subtyping, TDR determination, cluster (TC) analyses.In Portugal, the overall prevalence of was 11.0%. presented a decreasing trend 16.7% 9.2% 2016 (p for-trend = 0.114)....