Ιlias Papanikolaou
A5090997557- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Asthma and respiratory diseases
- Sepsis Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Respiratory and Cough-Related Research
- Eosinophilic Esophagitis
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Parasites and Host Interactions
- Drug-Induced Adverse Reactions
- Rheumatoid Arthritis Research and Therapies
- Vitamin D Research Studies
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Immune responses and vaccinations
Corfu General Clinic
2014-2025
General Hospital of Attica
2017-2021
University of Southern California
2009-2020
University General Hospital Attikon
2017
Sismanoglio General Hospital
2007-2014
Southern California University for Professional Studies
2009
Abstract Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative increased risk progression coronavirus disease 2019 (COVID-19) to respiratory failure. The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety anakinra, an IL-1α/β inhibitor, in 594 patients with COVID-19 at progressing failure as identified by plasma suPAR ≥6 ng ml −1 , 85.9% ( n = 510) whom were receiving dexamethasone. At day 28, adjusted...
It was studied if early suPAR-guided anakinra treatment can prevent severe respiratory failure (SRF) of COVID-19.A total 130 patients with suPAR ≥6 ng/ml were assigned to subcutaneous 100 mg once daily for 10 days. Primary outcome SRF incidence by day 14 defined as any ratio below 150 mmHg necessitating mechanical or non-invasive ventilation. Main secondary outcomes 30-day mortality and inflammatory mediators; 28-day WHO-CPS explored. Propensity-matched standard-of care comparators...
In a recent study of our group with the acronym ACTIVATE, Bacillus Calmete-Guérin (BCG) vaccination reduced occurrence new infections compared to placebo in elderly. Most benefit was found for respiratory infections. The ACTIVATE-2 launched assess efficacy BCG against coronavirus disease 2019 (COVID-19). this multicenter, double-blind trial, 301 volunteers aged 50 years or older were randomized (1:1) be vaccinated placebo. trial end points incidence COVID-19 and presence anti–severe acute...
Although major changes of the immune system have been described in sepsis, it has never studied whether these may differ relation to type underlying infection or not. This was for first time.The statuses innate and adaptive systems were prospectively compared 505 patients. Whole blood sampled within less than 24 hours advent sepsis; white cells stained with monoclonal antibodies analyzed though a flow cytometer.Expression HLA-DR significantly decreased among patients severe sepsis/shock due...
Abstract Background and Objective There remains a paucity of large databases for patients with idiopathic pulmonary fibrosis (IPF) lung cancer. We aimed to create European registry. Methods This was multicentre, retrospective study across seven countries between 1 January 2010 18 May 2021. Results identified 324 cancer among 3178 IPF (prevalence = 10.2%). By the end 10 year‐period following diagnosis, 26.6% alive had been diagnosed Patients experienced increased risk all‐cause mortality than...
Abstract Background Idiopathic Pulmonary Fibrosis (IPF) represents a chronic lung disease with unpredictable course. Methods We aimed to investigate prognostic performance of complete blood count parameters in IPF. Treatment-naïve patients IPF were retrospectively enrolled from two independent cohorts (derivation and validation) split into subgroups (high low) based on median baseline monocyte red cell distribution width (RDW). Results Overall, 489 cohort: 300, validation 189) analyzed. In...
Most patients infected with SARS-CoV-2 (COVID-19) experience mild, non-specific symptoms, but many develop severe symptoms associated an excessive inflammatory response. Elevated plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) provide early warning progression to respiratory failure (SRF) or death, access suPAR testing may be limited. The Severe COvid Prediction Estimate (SCOPE) score, derived from circulating C-reactive protein, D- dimers, interleukin-6,...
The COVID-19 pandemic has resulted in a growing number of patients experiencing persistent symptoms and physiological changes after recovering from acute SARS-CoV-2 infection, known as Long COVID. COVID is characterized by recurring inflammation across multiple organ systems. Diagnosis can be challenging, influenced factors like demographics, comorbidities, immune responses. impacts various systems have neuropsychological effects. Health disparities, particularly related to race, contribute...
SUMMARY BCG vaccination induces heterologous protection against respiratory tract infections, and in children improves survival independently of tuberculosis prevention. The phase III ACTIVATE-2 study assessed whether could also protect COVID19 the elderly. In this double-blind, randomized trial, elderly Greek patients were (1:1) to receive either revaccination or placebo at hospital discharge, followed by 6 months observation for incidence infection. resulted 68% risk reduction total...
<b><i>Introduction:</i></b> During the first COVID-19 wave, a considerable decline in hospital admissions was observed worldwide. <b><i>Aim:</i></b> This retrospective cohort study aimed to assess if there were any changes number of patients hospitalized for respiratory diseases Greece during COVID-19 wave. <b><i>Methods:</i></b> In present study, we evaluated disease hospitalization rates across 9 tertiary hospitals...
Post-acute sequelae of COVID-19 seem to be an emerging global crisis. Machine learning radiographic models have great potential for meticulous evaluation post-COVID-19 interstitial lung disease (ILD).In this multicenter, retrospective study, we included consecutive patients that had been evaluated 3 months following severe acute respiratory syndrome coronavirus 2 infection between 01/02/2021 and 12/5/2022. High-resolution computed tomography was through Imbio Lung Texture Analysis 2.1.Two...
The SAVE-MORE trial demonstrated that anakinra treatment in COVID-19 pneumonia with plasma soluble urokinase plasminogen activator (suPAR) levels of 6 ng/mL or more was associated 0.36 odds for a worse outcome compared to placebo when expressed by the WHO-Clinical Progression Scale (CPS) at day 28. Herein, we report results subgroup analyses and long-term outcomes.
Data on type 2 (T2)-low severe asthma (SA) frequency is scarce, resulting in an undefined unmet therapeutic need this patient population. Our objective was to assess the and characterize profile burden of T2-low SA Greece. PHOLLOW a cross-sectional study adult patients. Based novel proposed classification system, patients were classified as if blood eosinophil count (BEC; cells/μL) <150, fractional exhaled nitric oxide (FeNO) < 25 ppb any allergy status or BEC 150/FeNO 50 ppb/no 300/FeNO...
Background: Hypersensitivity pneumonitis (HP) represents a chronic lung disease with an unpredictable clinical course. There is pressing need for clinically applicable prognostic biomarkers in patients HP. Methods: This was observational, retrospective study. We investigated the potential of complete blood count parameters treatment-naïve diagnosed HP between 15 December 2010 and 1 October 2023. Receiver operating characteristic (ROC) curve analysis identified optimal cut-off thresholds each...
Data regarding the prognostic significance of pleural effusion (PE) are scarce.Explore impact PE on mortality among hospitalized patients.Multicenter prospective observational study. Patients that underwent computed tomography (thorax and/or abdomen) and in which was detected, were admitted to classified by size CT, anatomical distribution, diagnosis, Light's criteria. Charlson comorbidity index (CCI), APACHE II, SOFA score calculated. Mortality at 1 month year recorded.Five hundred eight...