Maria Saridaki
A5103206766- COVID-19 Clinical Research Studies
- Educational Games and Gamification
- Blood disorders and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Children's Physical and Motor Development
- Child Development and Digital Technology
- Salivary Gland Disorders and Functions
- Respiratory Support and Mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Inflammasome and immune disorders
- Respiratory viral infections research
- Inhalation and Respiratory Drug Delivery
- Digital Games and Media
- COVID-19 diagnosis using AI
- Online Learning and Analytics
- COVID-19 Impact on Reproduction
- Respiratory and Cough-Related Research
- Technology Use by Older Adults
- Flow Experience in Various Fields
- Assistive Technology in Communication and Mobility
- Digital Accessibility for Disabilities
- Privacy-Preserving Technologies in Data
National and Kapodistrian University of Athens
2011-2024
Laiko General Hospital of Athens
2023
Flinders Medical Centre
2021
Democritus University of Thrace
2021
Academy of Athens
2016
Fast and reliable detection of patients with severe heterogeneous illnesses is a major goal precision medicine1,2. Patients leukaemia can be identified using machine learning on the basis their blood transcriptomes3. However, there an increasing divide between what technically possible allowed, because privacy legislation4,5. Here, to facilitate integration any medical data from owner worldwide without violating laws, we introduce Swarm Learning-a decentralized machine-learning approach that...
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in call for better characterization understanding changes system. Methods In order dissect COVID-19-driven host responses, we performed RNA-seq whole blood cell transcriptomes...
It was studied if early suPAR-guided anakinra treatment can prevent severe respiratory failure (SRF) of COVID-19.A total 130 patients with suPAR ≥6 ng/ml were assigned to subcutaneous 100 mg once daily for 10 days. Primary outcome SRF incidence by day 14 defined as any ratio below 150 mmHg necessitating mechanical or non-invasive ventilation. Main secondary outcomes 30-day mortality and inflammatory mediators; 28-day WHO-CPS explored. Propensity-matched standard-of care comparators...
Most patients infected with SARS-CoV-2 (COVID-19) experience mild, non-specific symptoms, but many develop severe symptoms associated an excessive inflammatory response. Elevated plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) provide early warning progression to respiratory failure (SRF) or death, access suPAR testing may be limited. The Severe COvid Prediction Estimate (SCOPE) score, derived from circulating C-reactive protein, D- dimers, interleukin-6,...
Abstract Background Sepsis guidelines suggest immediate start of resuscitation for patients with quick Sequential Organ Failure Assessment (qSOFA) 2 or 3. However, the interpretation qSOFA 1 remains controversial. We investigated whether measurements soluble urokinase plasminogen activator receptor (suPAR) may improve risk detection when is 1. Methods The study had two parts. At first part, combination suPAR was analyzed in a prospective cohort early detection. second double-blind,...
<b><i>Background:</i></b> Macrophage activation-like syndrome (MALS) and complex immune dysregulation (CID) often underlie acute respiratory distress (ARDS) in COVID-19. We aimed to investigate the effect of personalized immunotherapy on clinical improvement critical <b><i>Methods:</i></b> In this open-label prospective trial, 102 patients with ARDS by SARS-CoV-2 were screened for MALS (ferritin &#x3e;4,420 ng/mL) CID ≤4,420 ng/mL low human...
Summary Type III interferons (IFNs) or IFN-λs (IFN-λ1/IL29, IFN-λ2/interleukin (IL)−28A and IFN-λ3/IL-28B) consist of a recently identified group IFNs, implicated initially in several human diseases, including cancer autoimmunity. In this study, we sought to investigate the expression type IFNs their common receptor IFN-λR1/IL-28Ra Sjögren's syndrome (SS). IFN was examined minor salivary gland tissues (MSG), peripheral blood mononuclear cells (PBMCs), sera resting Toll-like (TLR)-stimulated...
Recent publications on the probable role of heparin-binding protein (HBP) as a biomarker in sepsis prompted us to investigate its diagnostic and prognostic performance severe COVID-19. HBP IL-6 were measured by immunoassays at admission day 7 178 patients with pneumonia SARS-CoV-2. Patients classified into non-sepsis per Sepsis-3 definitions followed up for development respiratory failure (SRF) outcome. Results confirmed multivariate analyses. was significantly higher having negatively...
The epidemiology of severe lower respiratory tract infections (LRTI) is constantly changing. We aimed to describe it using the BioFire
Abstract Identification of patients with life-threatening diseases including leukemias or infections such as tuberculosis and COVID-19 is an important goal precision medicine. We recently illustrated that leukemia are identified by machine learning (ML) based on their blood transcriptomes. However, there increasing divide between what technically possible allowed because privacy legislation. To facilitate integration any omics data from owner world-wide without violating laws, we here...
SUMMARY The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in calls for better characterization understanding changes system. Here, we profiled whole blood transcriptomes 39 10 control donors enabling data-driven stratification based molecular phenotype....
Background Venous thromboembolism (VTE) contributes significantly to COVID-19 morbidity and mortality. The urokinase receptor system is involved in the regulation of coagulation. Levels soluble plasminogen activator (suPAR) reflect hyperinflammation are strongly predictive outcomes COVID-19. Whether suPAR levels identify patients with at risk for VTE unclear. Methods Results We leveraged a multinational observational study hospitalized D-dimer measured on admission. In 1960 (mean age, 58...
Digital storytelling combines the tradition of with digital technology. Creating stories invites participants to utilize multiple forms media in order construct and share their story. Moreover, it can provide opportunity cultivate skills creativity narration, exploring innovative technology, collaborating peers create own
The coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) can present with a broad range of clinical manifestations, ranging from asymptomatic to multiple organ failure. severity vary depending on factors such as age, sex, ethnicity, and pre-existing medical conditions. Despite efforts identify reliable prognostic biomarkers, predictive capacity these markers for outcomes remains poor. Circulating proteins, which reflect active mechanisms...
The purpose of this communication is to present a series observations made by researchers and educators on the incorporation serious games in educational experience users with intellectual disabilities.
ABSTRACT Introduction The management of pneumonia caused by SARS-CoV-2 should rely on early recognition the risk for progression to severe respiratory failure (SRF) and its prevention. We investigated if suPAR (soluble urokinase plasminogen activator receptor)-guided anakinra treatment could prevent COVID-19-assocated SRF. Methods In this open-label prospective trial, 130 patients admitted with levels ≥6 μg/l were assigned subcutaneous 100mg once daily 10 days. primary outcome was incidence...
The purpose of this paper is to present a series observations made by researchers and educators on the integration serious games in educational experience users with intellectual disabilities (ID). Data were gathered from four different studies used, order identify successful model based learning application. Moreover, results that highlight motivational importance playful towards promotion self determination students ID, will be presented. According authors’ findings, special education can...
ATLEC mobile application is a training and educational software targeted to people of all ages, including those with special needs disadvantaged groups, regardless their socio-economic background. offers four different ways accessing learning material about Assistive Technology products based on Information Communications Technologies (ICT-AT): context search (wizard situational parameters), free search, personalised list favorites. Users are also able upload own content demonstrate/teach...
The Europe 2020 strategy identifies drop out from i-VET or early school leaving (ESL) as a key challenge to meeting employment targets. Code RED project (http://www.codered-project.eu) has been developed in response the high levels of leaving, drop-out and exclusion education that often lead unemployment, poverty social deprivation. In taking actions towards achieving its goals, experimenting with (serious) games' co-design methodology [1] through dedicated workshops' series, run within 2014...
We conducted a single-center, non-interventional retrospective study of melanoma patients with COVID-19 (1 March 2020 until 17 2023). The cohort was further divided into three groups according to the periods SARS-CoV-2 variant dominance in Greece. recorded demographics, comorbidities, vaccination data, cancer diagnosis/stage, types systemic treatments, date diagnosis and survival. identified 121 patients. vast majority (87.6%) had advanced disease (stages III or IV). A total 80.1% were...
ABSTRACT Rationale Macrophage activation syndrome (MAS) and complex immune dysregulation (CID) often underlie acute respiratory distress (ARDS) in COVID-19. Objective To investigate the outcome of personalized immunotherapy critical Methods In this open-label prospective trial, 102 patients with SOFA (sequential organ failure assessment) score ≥2 or ARDS by SARS-CoV-2 were screened for MAS (ferritin more than 4420 ng/ml) CID ≤4420 ng/ml low expression HLA-DR on CD14-monocytes). Patients...