A5040220164- COVID-19 Clinical Research Studies
- Eosinophilic Esophagitis
- Long-Term Effects of COVID-19
- Mast cells and histamine
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Respiratory Support and Mechanisms
- Urticaria and Related Conditions
- Inflammatory mediators and NSAID effects
- Hidradenitis Suppurativa and Treatments
- Eosinophilic Disorders and Syndromes
- Migration, Health and Trauma
- Microscopic Colitis
- Cell death mechanisms and regulation
- COVID-19 Impact on Reproduction
- Cardiac Arrest and Resuscitation
- Hematopoietic Stem Cell Transplantation
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiac, Anesthesia and Surgical Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- COVID-19 and healthcare impacts
- Drug-Induced Adverse Reactions
- Phagocytosis and Immune Regulation
University of North Carolina at Chapel Hill
2023-2025
University of Michigan
2020-2024
Michigan United
2023
University of North Carolina Health Care
2023
Nationwide Children's Hospital
2022
Duke University
2018-2020
Ann Arbor Center for Independent Living
2020
Duke University Hospital
2017
Duke Medical Center
2017
Abstract Objectives To estimate the incidence, risk factors, and outcomes associated with in-hospital cardiac arrest cardiopulmonary resuscitation in critically ill adults coronavirus disease 2019 (covid-19). Design Multicenter cohort study. Setting Intensive care units at 68 geographically diverse hospitals across United States. Participants Critically (age ≥18 years) laboratory confirmed covid-19. Main outcome measures In-hospital within 14 days of admission to an intensive unit mortality....
OBJECTIVE Depression is the most prevalent affective disorder in US, and patients with spinal deformity are at increased risk. Postoperative delirium has been associated inferior surgical outcomes, including morbidity mortality. The relationship between depression postoperative undergoing spine surgery relatively unknown. aim of this study was to determine if an independent risk factor for development decompression fusion deformity. METHODS medical records 923 adult (age ≥ 18 years) elective...
Hematopoietic stem cell transplantation (HSCT) is associated with various cardiovascular (CV) complications. We sought to characterize the incidence and risk factors for short-term long-term CV events in a contemporary cohort of adult HSCT recipients. conducted multicenter observational study patients who underwent autologous or allogeneic between 2008 2019. Data on demographics, clinical characteristics, conditioning regimen, outcomes were collected through chart review. composite death,...
Summary The eosinophilic esophagitis (EoE) Endoscopic Reference Score (EREFS) measures endoscopic severity. While a score of ≤2 has been proposed for response, it is unknown whether achieving this threshold results in clinically important outcomes. We aimed to determine an EREFS response topical steroids (tCS) associated with decreased need future esophageal dilation. In retrospective cohort study, we included patients new diagnosis EoE who underwent dilation, were then treated tCS, and had...
The tumor microenvironment within the breast is rich in adipose elements. interaction between cells and cancer poorly understood, particularly as it pertains to patients with genetic susceptibility cancer. This study focuses on phenotype of human adipose-derived stem BRCA1 mutation effect they may have cell behavior.CRISPR/Cas9 was used generate de novo BRCA1-knockdown cells. knockdown compared wild-type patient-derived known mutations. Interactions MDA-MB-231 line were...
Clinical Implications•Patients with mastocytosis and monoclonal mast cell activation syndrome tolerate COVID-19 vaccination. •Patients Mastocytosis is characterized by abnormal clonal expansion accumulation in one or more organ systems. Symptoms of these patients include pruritus, flushing, recurrent anaphylaxis. Lifetime risk for anaphylaxis greatly increased over the general population has been reported up to 49% some cohorts.1Brockow K. Jofer C. Behrendt H. Anaphylaxis mastocytosis: a...
Background Venous thromboembolism (VTE) contributes significantly to COVID-19 morbidity and mortality. The urokinase receptor system is involved in the regulation of coagulation. Levels soluble plasminogen activator (suPAR) reflect hyperinflammation are strongly predictive outcomes COVID-19. Whether suPAR levels identify patients with at risk for VTE unclear. Methods Results We leveraged a multinational observational study hospitalized D-dimer measured on admission. In 1960 (mean age, 58...
Evidence guiding the pre-hematopoietic stem cell transplantation (HSCT) cardiovascular evaluation is limited. We sought to derive and validate a pre-HSCT score for risk stratification of HSCT candidates.
Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, treatment.To investigate the AD HS.We performed a retrospective cohort study of patients seen at Duke University Medical Center from 2007 to 2017 who had compared with control group without an diagnosis. The HS was evaluated using logistic regression model after...
Cannabis use is becoming increasingly common, both for recreational and medical purposes. However, there a paucity of data regarding cannabis in the context eosinophilic esophagitis (EoE). We aimed to determine impact on presentation treatment response EoE. To this end, we conducted retrospective cohort study at large academic center newly diagnosed EoE patients age ≥ 12 years. Self-reported status, baseline characteristics, topical corticosteroids dietary therapy were extracted. Bivariate...
<h3>BACKGROUND</h3> This study explored the health needs, trends of care utilization, and barriers to a diverse population refugee children resettled in Durham County, North Carolina. <h3>METHODS</h3> Researchers conducted retrospective chart review 327 pediatric (aged 0-21 years) patients who received at Lincoln Community Health Center from 2016 2018. <h3>RESULTS</h3> Results describe low prevalence infectious diseases, such as human immunodeficiency virus (0%), hepatitis B (2%),...
Abstract Background Unplanned returns to the operating room (OR) may be necessary at times salvage a compromised free flap. The aim of this study was assess influence attending surgeon continuity on flap outcomes following return OR. Methods We retrospectively reviewed patients who underwent reconstruction and experienced an unplanned OR within 30 days from 2002 2017. Logistic regression modeling used determine factors that predict Results Of 1,177 were identified, 267 (22.5%) had these, 69...
Historically, torture often was understood as physical and/or psychological pain inflicted by governmental agents on an individual who is detained or imprisoned in custody. As defined the United Nations Convention Against Torture (UNCAT), however, increasingly recognized occurring settings far beyond carceral settings.