A5024745776- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Effects of Radiation Exposure
- Prostate Cancer Treatment and Research
- Chemotherapy-induced cardiotoxicity and mitigation
- DNA Repair Mechanisms
- Cardiac Imaging and Diagnostics
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- Global Cancer Incidence and Screening
- Breast Implant and Reconstruction
- Advanced MRI Techniques and Applications
- Hematopoietic Stem Cell Transplantation
- Coronary Interventions and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Sexual Differentiation and Disorders
- Cardiovascular Function and Risk Factors
- Childhood Cancer Survivors' Quality of Life
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Infectious Diseases and Mycology
- Family Support in Illness
University of Michigan
2023-2025
Nottingham University Hospitals NHS Trust
2015-2024
Beth Israel Deaconess Medical Center
2023
Harvard University
2023
Nottingham City Hospital
2017
Queen's Medical Centre
2016
NIHR Nottingham Digestive Diseases Biomedical Research Unit
2016
University of Nottingham
2016
Eastern Hepatobiliary Surgery Hospital
2016
Second Military Medical University
2016
Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit patients with liver metastases liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy SIRT using yttrium-90 resin microspheres metastases. were designed combined analysis overall survival.
To study the impact of transarterial Yttrium-90 radioembolization (TARE) in combination with second-line systemic chemotherapy for colorectal liver metastases (CLM).In this international, multicenter, open-label phase III trial, patients CLM who progressed on oxaliplatin- or irinotecan-based first-line therapy were randomly assigned 1:1 to receive without TARE. The two primary end points progression-free survival (PFS) and hepatic PFS (hPFS), assessed by blinded independent central review....
Response to radiotherapy varies between individuals both in terms of efficacy and adverse reactions. Finding genetic determinants radiation response would allow the tailoring treatment, either by altering dose or surgery. Despite a growing number studies radiogenomics, there are no well-replicated association results. We carried out candidate gene study replicated result using three additional large cohorts, total 2036 women scored for reactions breast cancer. Genetic variation near tumour...
Hematopoietic stem cell transplantation (HSCT) is associated with various cardiovascular (CV) complications. We sought to characterize the incidence and risk factors for short-term long-term CV events in a contemporary cohort of adult HSCT recipients. conducted multicenter observational study patients who underwent autologous or allogeneic between 2008 2019. Data on demographics, clinical characteristics, conditioning regimen, outcomes were collected through chart review. composite death,...
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a five-year survival rate 13%. The tumor microenvironment (TME) in PDAC includes heterogeneous population cells. In genetically engineered mouse models, TME evolves alongside formation and progression epithelial precursor lesions to cancer. However, evolution human samples has not been thoroughly characterized, primarily due limited access pre-malignant pancreatic tissue. Leveraging collaboration Gift...
3507 Background: The FOXFIRE, SIRFLOX and FOXFIRE-Global (FF-SF-FFG) randomized studies evaluated the efficacy of combining first-line chemotherapy for metastatic colorectal cancer (mCRC) with selective internal radiotherapy (SIRT) using yttrium-90 resin microspheres in patients liver metastases. were designed prospective, combined analysis overall survival (OS). Methods: FF-SF-FFG (1:1) chemotherapy-naïve mCRC (performance status 0/1) metastases not suitable curative resection/ablation. Arm...
Evidence guiding the pre-hematopoietic stem cell transplantation (HSCT) cardiovascular evaluation is limited. We sought to derive and validate a pre-HSCT score for risk stratification of HSCT candidates.
Overall, ∼5% of patients show late normal-tissue damage after radiotherapy with a smaller number having risk radiation-induced heart disease. Although the data are conflicting, large studies have shown increased risks cardiovascular disease (CVD) for irradiated compared non-irradiated ones, or those treated to left breast chest wall right. Cutaneous telangiectasiae as injury so far only been regarded cosmetic burden. The relationship between radiation phenotypes in 149 cancer and presence...
To evaluate the outcome of patients with bilobar colorectal liver metastases (CRLM) and identify clinico-pathological variables that influenced survival.Patients CRLM were identified from a prospectively maintained hepatobiliary database during study period (January 2010-June 2014). Collated data included demographics, primary tumour treatment, surgical data, histopathology analysis clinical outcome. Down-staging therapy Oxaliplatin- or Irinotecan- based regimens, Cetuximab was also used in...
The presence of germline mutations plays an increasingly important role in risk assessment and treatment prostate cancer (PrCa). Screening for high-risk subsets patients is becoming routine. We explore the prevalence genetic men with metastatic castration-resistant (mCRPC) recruited to BARCODE2 trial.
e16001 Background: Undifferentiated carcinoma (UC) is a rare subtype of pancreatic and can present with or without osteoclast-like giant cells (OGC). This 2010 delineation complicates interpretation prior studies comparing UC to ductal adenocarcinomas (PDAC). Limited retrospective data suggest UC-OGC tumors correspond younger age, larger size, worse prognosis compared UC. The role OGC hypothesized alter the immune microenvironment tumors, leading different response therapy PDAC. Methods: aim...